中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
机构
上海药物研究所 [3]
上海营养与健康研究所 [2]
近代物理研究所 [2]
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OAI收割 [12]
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期刊论文 [12]
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2024 [2]
2020 [2]
2019 [1]
2017 [1]
2012 [1]
2011 [2]
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Biochemist... [1]
Oncology [1]
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An overview of PROTACs targeting MDM2 as a novel approach for cancer therapy
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 272, 页码: 8
作者:
Li, Huiwen
;
Cai, Xinhui
;
Yang, Xiaoyu
;
Zhang, Xuan
  |  
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2024/09/26
MDM2
PROTAC
p53
MDMX
Targeted protein degradation
Synthesis and biological evaluation of 4-imidazolidinone-containing compounds as potent inhibitors of the MDM2/p53 interaction
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 270, 页码: 16
作者:
Lin, Zhitong
;
Liu, Chen
;
Yan, Ziqin
;
Cheng, Jing
;
Wang, Xiancheng
  |  
收藏
  |  
浏览/下载:30/0
  |  
提交时间:2024/06/27
MDM2
p53
p21
Imidazolidinone
Apoptosis
Targeting MDMX for Cancer Therapy: Rationale, Strategies, and Challenges
期刊论文
OAI收割
FRONTIERS IN ONCOLOGY, 2020, 卷号: 10
作者:
Yu, De-Hua
;
Xu, Zhi-Yuan
;
Mo, Shaowei
;
Yuan, Li
;
Cheng, Xiang-Dong
  |  
收藏
  |  
浏览/下载:35/0
  |  
提交时间:2020/10/26
MDMX
MDM2
p53
oncogene
tumor suppressor
inhibitors
The MDM2/MDMX/p53 axis in the adaptive stress response
期刊论文
OAI收割
TRANSLATIONAL CANCER RESEARCH, 2020, 卷号: 9, 期号: 3, 页码: 1993-1997
作者:
Wang, Bing
;
Rasmussen-Ivey, Cody
;
Little, John B.
;
Yuan, Zhi-Min
  |  
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2022/01/18
The MDM2/MDMX/p53 axis
mild stress
adaptive stress response
cell fate
Prolyl hydroxylase 3 stabilizes the p53 tumor suppressor by inhibiting the p53-MDM2 interaction in a hydroxylase-independent manner
期刊论文
OAI收割
JOURNAL OF BIOLOGICAL CHEMISTRY, 2019, 卷号: 294, 期号: 25, 页码: 9949-9958
作者:
Xu, Yiming
;
Gao, Qiang
;
Xue, Yaqian
;
Li, Xiuxiu
;
Qin, Yanqing
  |  
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2020/12/09
p53
protein stability
mouse double minute 2 homolog (MDM2)
cancer stem cells
colon cancer
prolyl hydroxylase 3
Adaptive evolution of proteins in hepatitis B virus during divergence of genotypes
期刊论文
OAI收割
SCIENTIFIC REPORTS, 2017, 卷号: 7, 期号: -, 页码: 1990
作者:
Li, Shengdi
;
Wang, Zhen
;
Li, Yixue
;
Ding, Guohui
;
Li, Yixue
  |  
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2020/12/09
p53
protein stability
mouse double minute 2 homolog (MDM2)
cancer stem cells
colon cancer
prolyl hydroxylase 3
Molecular Dynamic Simulation Insights into the Normal State and Restoration of p53 Function
期刊论文
OAI收割
international journal of molecular sciences, 2012, 卷号: 13, 期号: 8, 页码: 9709-9740
作者:
Fu, Ting
;
Min, Hanyi
;
Xu, Yong
;
Chen, Jianzhong
;
Li, Guohui
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2013/10/11
p53
MDM2
MDMX
molecular dynamic simulation
conformational change
protein-protein interaction
protein-ligand interaction
A Cell-Based High-Throughput Assay for the Screening of Small-Molecule Inhibitors of p53-MDM2 Interaction
期刊论文
OAI收割
JOURNAL OF BIOMOLECULAR SCREENING, 2011, 卷号: 16, 期号: 4, 页码: 450-456
作者:
Li, Jing
;
Zhang, Shuyong
;
Gao, Linghuan
;
Chen, Ying
;
Xie, Xin
  |  
收藏
  |  
浏览/下载:32/0
  |  
提交时间:2019/01/08
p53
MDM2
small-molecule inhibitor
protein-protein interaction
high-throughput screening
Anchoring Intrinsically Disordered Proteins to Multiple Targets: Lessons from N-Terminus of the p53 Protein
期刊论文
OAI收割
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2011, 卷号: 12, 期号: 2, 页码: 1410-1430
作者:
Huang, Yongqi
;
Liu, Zhirong
  |  
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2019/04/09
Anchor Residue
Intrinsically Disordered Proteins
Binding Promiscuity
Molecular Recognition Features
P53
Mdm2
Taz2
Ablation of TNF or lymphotoxin signaling and the frequency of spontaneous tumors in p53-deficient mice
期刊论文
OAI收割
CANCER LETTERS, 2008, 卷号: 268, 期号: 1, 页码: 70-75
Kuprash, Dmitry V
;
Qin, Zhihai
;
秦志海
;
Ito, Daisuke
;
Grivennikov, Sergei I
;
Abe, Koichiro
;
Drutskaya, Ludmila N
;
Blankenstein, Thomas
;
Nedospasov, Sergel A
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2013/12/25
cytokine and chemokine biology
p53/mdm2
tumor immunology
knockout mice