机构

• 上海药物研究所 [6]
• 合肥物质科学研究院 [1]

采集方式

• OAI收割 [7]

内容类型

• 期刊论文 [7]

发表日期

• 2024 [1]
• 2023 [1]
• 2022 [1]
• 2020 [3]
• 2017 [1]

学科主题

筛选

浏览/检索结果: 共7条，第1-7条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择题名升序题名降序提交时间升序提交时间降序作者升序作者降序发表日期升序发表日期降序 Design, synthesis and evaluation of thieno[3,2-d]pyrimidine derivatives as novel potent CDK7 inhibitors 期刊论文  OAI收割 BIOORGANIC CHEMISTRY, 2024, 卷号: 148, 页码: 15 作者:  Zhang, Hongjin;  Lin, Guohao;  Jia, Suyun;  Wu, Jianbo;  Zhang, Ying   |  收藏  |  浏览/下载：14/0  |  提交时间：2024/09/26 Cyclin-dependent kinase 7  Small molecular inhibitor  Triple negative breast cancer  Thieno[3,2-d]pyrimidine derivative   Discovery of HCD3514 as a potent EGFR inhibitor against C797S mutation in vitro and in vivo 期刊论文  OAI收割 JOURNAL OF CANCER, 2023, 卷号: 14, 期号: 1, 页码: 152-162 作者:  Lai, Mengzhen;  Zhang, Tao;  Chen, Hao;  Song, Peiran;  Tong, Linjiang   |  收藏  |  浏览/下载：121/0  |  提交时间：2023/04/10 fourth-generation EGFR inhibitor  EGFRC797S mutation  NSCLC  drug resistance  small molecular inhibitor   Safety and Efficacy of D-1553 in Patients with KRAS G12C Mutated Non-Small Cell Lung Cancer: A Phase 1 Trial 期刊论文  OAI收割 JOURNAL OF THORACIC ONCOLOGY, 2022, 卷号: 17 作者:  Lu, S.;  Jian, H.;  Zhang, Y.;  Song, Z.;  Zhao, Y.   |  收藏  |  浏览/下载：37/0  |  提交时间：2022/12/23 Non-small cell lung cancer  KRAS G12C mutation  Small molecular inhibitor   Lead discovery, chemical optimization, and biological evaluation studies of novel histone methyltransferase SET7 small-molecule inhibitors 期刊论文  OAI收割 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2020, 卷号: 30, 期号: 9, 页码: 10 作者:  Hou, Zeng;  Min, Wenjian;  Zhang, Rukang;  Niu, Ao;  Li, Yuanqing   |  收藏  |  浏览/下载：54/0  |  提交时间：2020/07/01 Histone methylation  SET7  Small-molecule inhibitor  Virtual screening  Molecular probe   Discovery of novel CBP bromodomain inhibitors through TR-FRET-based high-throughput screening 期刊论文  OAI收割 ACTA PHARMACOLOGICA SINICA, 2020, 卷号: 41, 期号: 2, 页码: 286-292 作者:  Zhang, Feng-cai;  Sun, Zhong-ya;  Liao, Li-ping;  Zuo, Yu;  Zhang, Dan   |  收藏  |  浏览/下载：63/0  |  提交时间：2020/07/01 CBP bromodomain  small-molecule inhibitor  high-throughput screening  TR-FRET  molecular modeling  human leukemia MV4-11 cells   The Development of Inhibitors Targeting the Mixed Lineage Leukemia 1 (MLL1)-WD Repeat Domain 5 Protein (WDR5) Protein-Protein Interaction 期刊论文  OAI收割 CURRENT MEDICINAL CHEMISTRY, 2020, 卷号: 27, 期号: 33, 页码: 5530-5542 作者:  Ye, Xiaoqing;  Chen, Gang;  Jin, Jia;  Zhang, Binzhong;  Wang, Yinda   |  收藏  |  浏览/下载：29/0  |  提交时间：2020/12/24 WDR5  MLL1  histone methyltransferase  small-molecular inhibitor  epigenetics  human acute leukemia   Discovery of alkyl bis(oxy)dibenzimidamide derivatives as novel protein arginine methyltransferase 1 (PRMT1) inhibitors 期刊论文  OAI收割 CHEMICAL BIOLOGY & DRUG DESIGN, 2017, 卷号: 90, 期号: 6, 页码: 1260-1270 作者:  Zhang, Wei-yao;  Lu, Wen-chao;  Jiang, Hao;  Lv, Zheng-bing;  Xie, Yi-qian   |  收藏  |  浏览/下载：36/0  |  提交时间：2019/01/08 epigenetics  molecular docking  PRMT1  scaffold hopping  small-molecule inhibitor