中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
机构
上海药物研究所 [10]
心理研究所 [1]
昆明植物研究所 [1]
动物研究所 [1]
合肥物质科学研究院 [1]
采集方式
OAI收割 [14]
内容类型
期刊论文 [14]
发表日期
2021 [14]
学科主题
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发表日期:2021
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Discovery of a Novel Androgen Receptor Antagonist Manifesting Evidence to Disrupt the Dimerization of the Ligand-Binding Domain via Attenuating the Hydrogen-Bonding Network Between the Two Monomers
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64
作者:
Fu, Weitao
;
Zhang, Minkui
;
Liao, Jianing
;
Tang, Qing
;
Lei, Yixuan
  |  
收藏
  |  
浏览/下载:30/0
  |  
提交时间:2022/03/21
Structures of the human cholecystokinin receptors bound to agonists and antagonists
期刊论文
OAI收割
NATURE CHEMICAL BIOLOGY, 2021, 卷号: 17, 期号: 12, 页码: 1230-1237
作者:
Zhang, Xuefeng
;
He, Chenglin
;
Wang, Mu
;
Zhou, Qingtong
;
Yang, Dehua
  |  
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2024/03/21
Structure-Based Design of Dual-Acting Compounds Targeting Adenosine A(2A) Receptor and Histone Deacetylase as Novel Tumor Immunotherapeutic Agents
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 22, 页码: 16573-16597
作者:
Yan, Wenzhong
;
Ling, Lijun
;
Wu, Yiran
;
Yang, Kexin
;
Liu, Ruiquan
  |  
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2022/06/15
Glycan Epitopes and Potential Glycoside Antagonists of DC-SIGN Involved in COVID-19: In Silico Study
期刊论文
OAI收割
BIOMOLECULES, 2021, 卷号: 11, 期号: 11, 页码: 16
作者:
Gao, Meina
;
Li, Hui
;
Ye, Chenghao
;
Chen, Kaixian
;
Jiang, Hualiang
  |  
收藏
  |  
浏览/下载:53/0
  |  
提交时间:2022/01/04
DC-SIGN
glycan epitopes
carbohydrate recognition mechanism
natural glycoside antagonists
molecular dynamics simulations
COVID-19
Constitutive signal bias mediated by the human GHRHR splice variant 1
期刊论文
OAI收割
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2021, 卷号: 118, 期号: 40, 页码: 10
作者:
Cong, Zhaotong
;
Zhou, Fulai
;
Zhang, Chao
;
Zou, Xinyu
;
Zhang, Huibing
  |  
收藏
  |  
浏览/下载:57/0
  |  
提交时间:2021/12/01
class B1 GPCR
receptor bias
cancer
cell proliferation
Supramolecular Antagonists Promote Mitochondrial Dysfunction
期刊论文
OAI收割
NANO LETTERS, 2021, 卷号: 21, 期号: 13, 页码: 5730-5737
作者:
Li, Mingming
;
Song, Yanqiu
;
Song, Na
;
Wu, Guangyao
;
Zhou, Hao
  |  
收藏
  |  
浏览/下载:31/0
  |  
提交时间:2021/08/17
Self-Assembly
Peptides
Drug Delivery
Mitochondrion-Targeting
Antagonists
Affinity Mass Spectrometry-Based Fragment Screening Identified a New Negative Allosteric Modulator of the Adenosine A(2A) Receptor Targeting the Sodium Ion Pocket
期刊论文
OAI收割
ACS CHEMICAL BIOLOGY, 2021, 卷号: 16, 期号: 6, 页码: 991-1002
作者:
Lu, Yan
;
Liu, Hongyue
;
Yang, Dehua
;
Zhong, Li
;
Xin, Ye
  |  
收藏
  |  
浏览/下载:52/0
  |  
提交时间:2021/08/17
Amygdala dynorphin/kappa opioid receptor system modulates depressive-like behavior in mice following chronic social defeat stress
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 11
作者:
Zan, Gui-ying
;
Sun, Xiang
;
Wang, Yu-jun
;
Liu, Rui
;
Wang, Chen-yao
  |  
收藏
  |  
浏览/下载:42/0
  |  
提交时间:2021/08/17
depression
social defeat stress
amygdala
κ
opioid receptor
dynorphin
c-fos
ERK
norBNI
Discovery of 1,5-Dihydro-4H-imidazol-4-one Derivatives as Potent, Selective Antagonists of CXC Chemokine Receptor 2
期刊论文
OAI收割
ACS MEDICINAL CHEMISTRY LETTERS, 2021, 卷号: 12, 期号: 5, 页码: 836-845
作者:
Che, Jinxin
;
Wang, Zhilong
;
Shen, Zheyuan
;
Zhuang, Weihao
;
Ying, Huazhou
  |  
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2021/08/17
cancer metastasis
CXCR1
CXCR2
selectivity
antagonist
1,5-dihydro-4H-imidazol-4-one
Structural basis for ligand recognition of the neuropeptide Y Y-2 receptor
期刊论文
OAI收割
NATURE COMMUNICATIONS, 2021, 卷号: 12, 期号: 1, 页码: 9
作者:
Tang, Tingting
;
Hartig, Christin
;
Chen, Qiuru
;
Zhao, Wenli
;
Kaiser, Anette
  |  
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2021/05/24