中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
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上海药物研究所 [10]
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Structural perspective of class B1 GPCR signaling
期刊论文
OAI收割
TRENDS IN PHARMACOLOGICAL SCIENCES, 2022, 卷号: 43, 期号: 4, 页码: 321-334
作者:
Cong, Zhaotong
;
Liang, Yi-Lynn
;
Zhou, Qingtong
;
Darbalaei, Sanaz
;
Zhao, Fenghui
  |  
收藏
  |  
浏览/下载:33/0
  |  
提交时间:2022/06/15
Adolescent chronic unpredictable stress causes a bias in goal-directed behavior and distinctively changes the expression of NMDA and dopamine receptors in the dorsomedial and dorsolateral striatum in male rats
期刊论文
OAI收割
DEVELOPMENTAL PSYCHOBIOLOGY, 2022, 卷号: 64, 期号: 2, 页码: 10
作者:
Wu, Chao
;
Zheng, Wei
;
Jia, Xiaohua
;
Li, Yonghui
;
Shen, Fang
  |  
收藏
  |  
浏览/下载:40/0
  |  
提交时间:2022/04/08
adolescent
chronic unpredictable stress
dorsolateral striatum
goal-directed behavior
NR2B receptor
Computational characterization of transducer recognition of 132 adrenergic receptor
期刊论文
OAI收割
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2022, 卷号: 592, 页码: 67-73
作者:
Zhao, Lifen
;
He, Xinheng
;
Jiang, Hualiang
;
Cheng, Xi
  |  
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2022/06/15
Class A G-protein coupled receptor
Coupling selectivity
Transducer-binding interface
Functional signal
Complex models
Constitutive signal bias mediated by the human GHRHR splice variant 1
期刊论文
OAI收割
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2021, 卷号: 118, 期号: 40, 页码: 10
作者:
Cong, Zhaotong
;
Zhou, Fulai
;
Zhang, Chao
;
Zou, Xinyu
;
Zhang, Huibing
  |  
收藏
  |  
浏览/下载:57/0
  |  
提交时间:2021/12/01
class B1 GPCR
receptor bias
cancer
cell proliferation
Different conformational responses of the beta(2)-adrenergic receptor-Gs complex upon binding of the partial agonist salbutamol or the full agonist isoprenaline
期刊论文
OAI收割
NATIONAL SCIENCE REVIEW, 2021, 卷号: 8
作者:
Yang, Fan
;
Ling, Shenglong
;
Zhou, Yingxin
;
Zhang, Yanan
;
Lv, Pei
  |  
收藏
  |  
浏览/下载:30/0
  |  
提交时间:2021/11/01
cryo-EM structure
G protein-coupled receptor (GPCR)
partial and full agonists
conformational change
desensitization
Structural basis of GPBAR activation and bile acid recognition
期刊论文
OAI收割
NATURE, 2020, 页码: 29
作者:
Yang, Fan
;
Mao, Chunyou
;
Guo, Lulu
;
Lin, Jingyu
;
Ming, Qianqian
  |  
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2020/12/24
Pharmacological characterization of mono-, dual- and tri-peptidic agonists at GIP and GLP-1 receptors
期刊论文
OAI收割
BIOCHEMICAL PHARMACOLOGY, 2020, 卷号: 177, 页码: 13
作者:
Yuliantie, Elita
;
Darbalaei, Sanaz
;
Dai, Antao
;
Zhao, Peishen
;
Yang, Dehua
  |  
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2020/12/24
G protein-coupled receptor
Glucose-dependent insulinotropic peptide receptor
Glucagon-like peptide-1 receptor
Biased agonist
GPCR signaling
前额叶皮层 CRFR1在 慢性应激导致习惯化行为偏好 中 的 作用
学位论文
OAI收割
中国科学院心理研究所: 中国科学院心理研究所, 2020
作者:
陈星
  |  
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2021/01/04
慢性应激
目标导向行为
习惯化行为
下边缘皮质
促肾上腺皮质激素释放因子
A Novel G Protein-Biased and Subtype-Selective Agonist for a G Protein-Coupled Receptor Discovered from Screening Herbal Extracts
期刊论文
OAI收割
ACS CENTRAL SCIENCE, 2020, 卷号: 6, 期号: 2, 页码: 213-225
作者:
Zhang, Bingjie
;
Zhao, Simeng
;
Yang, Dehua
;
Wu, Yiran
;
Xin, Ye
  |  
收藏
  |  
浏览/下载:33/0
  |  
提交时间:2020/07/01
How Does Agonist and Antagonist Binding Lead to Different Conformational Ensemble Equilibria of the kappa-Opioid Receptor: Insight from Long-Time Gaussian Accelerated Molecular Dynamics Simulation
期刊论文
OAI收割
ACS CHEMICAL NEUROSCIENCE, 2019, 卷号: 10, 期号: 3, 页码: 1575-1584
作者:
An, Xiaoli
;
Bai, Qifeng
;
Bing, Zhitong
;
Zhou, Shuangyan
;
Shi, Danfeng
  |  
收藏
  |  
浏览/下载:57/0
  |  
提交时间:2019/11/10
kappa-opioid receptor
Gaussian accelerated molecular dynamics simulation
agonist
antagonist
conformational change