中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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上海药物研究所 [30]
大连化学物理研究所 [29]
长春应用化学研究所 [7]
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南京地质古生物研究所 [2]
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期刊论文 [60]
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物理化学 [13]
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Simultaneous determination of almonertinib and its active metabolite HAS-719 in human plasma by LC-MS/MS: Evaluation of pharmacokinetic interactions
期刊论文
OAI收割
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2022, 卷号: 1197, 页码: 7
作者:
Liu, Lu
;
Yang, Le
;
Li, Wei
;
Chen, Xiaoyan
  |  
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2022/08/16
Almonertinib
LC -MS
MS
Active metabolite (HAS-719)
Pharmacokinetic drug-drug interaction
Itraconazole and rifampicin, as CYP3A modulators but not P-gp modulators, affect the pharmacokinetics of almonertinib and active metabolite HAS-719 in healthy volunteers
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 9
作者:
Liu, Lu
;
Li, Wei
;
Yang, Le
;
Guo, Zi-tao
;
Xue, Hao
  |  
收藏
  |  
浏览/下载:46/0
  |  
提交时间:2021/08/17
almonertinib
itraconazole
rifampicin
drug metabolism
drug interaction
CYP3A
P-gp
pharmacokinetics
Cytochrome P450-Mediated Metabolism and CYP Inhibition for the Synthetic Peroxide Antimalarial OZ439
期刊论文
OAI收割
ACS INFECTIOUS DISEASES, 2021, 卷号: 7, 期号: 7, 页码: 1885-1893
作者:
Shackleford, David M.
;
Chiu, Francis C. K.
;
Katneni, Kasiram
;
Blundell, Scott
;
McLaren, Jenna
  |  
收藏
  |  
浏览/下载:40/0
  |  
提交时间:2021/11/04
OZ439 (artefenomel)
malaria
metabolite identification
cytochrome P450 metabolism
cytochrome P450 inhibition
time-dependent inhibition
Quantification of Usaramine and its N-Oxide Metabolite in Rat Plasma Using Liquid Chromatography-Tandem Mass Spectrometry
期刊论文
OAI收割
JOURNAL OF ANALYTICAL TOXICOLOGY, 2021, 卷号: 46, 期号: 5, 页码: 512-518
作者:
Lin, Feifei
;
Ma, Yan
;
Pan, Anni
;
Ye, Yang
;
Liu, Jia
  |  
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2022/08/16
Pharmacokinetic Drug-drug Interaction of Antibiotics Used in Sepsis Care in China
期刊论文
OAI收割
CURRENT DRUG METABOLISM, 2021, 卷号: 22, 期号: 1, 页码: 5-23
作者:
Yu, Xuan
;
Chu, Zixuan
;
Li, Jian
;
He, Rongrong
;
Wang, Yaya
  |  
收藏
  |  
浏览/下载:95/0
  |  
提交时间:2021/05/24
Pharmacokinetics
drug-drug interaction
antibiotic
sepsis
transporter
enzyme
Species differences in the CYP3A-catalyzed metabolism of TPN729, a novel PDE5 inhibitor
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2020, 页码: 9
作者:
Tian, Qian-qian
;
Zhu, Yun-ting
;
Diao, Xing-xing
;
Zhang, Xiang-lei
;
Xu, Ye-chun
  |  
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2020/12/24
PDE5 inhibitor
TPN729
M3
species difference
pharmacokinetics
metabolite identification
电子垃圾拆解区复合污染水体中鱼的转录组特征与适应机制
学位论文
OAI收割
北京: 中国科学院生态环境研究中心, 2019
作者:
张望龙
  |  
收藏
  |  
浏览/下载:44/0
  |  
提交时间:2020/07/29
电子垃圾,生态毒理,ahr,转录组,适应机制
electronic Waste, Ecotoxicology, Aryl Hydrocarbon Receptor, Transcriptome, Adaptation
Intravenous formulation of Panax notoginseng root extract: human pharmacokinetics of ginsenosides and potential for perpetrating drug interactions
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2019, 卷号: 40, 期号: 10, 页码: 1351-1363
作者:
Pintusophon, Salisa
;
Niu, Wei
;
Duan, Xiao-na
  |  
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2020/07/01
ginsenoside
cytochrome P450 3A
organic anion-transporting polypeptide 1B3
herbal medicine-drug interactions
XueShuanTong
Panax notoginseng
Transcriptomic analysis of Anabas testudineus and its defensive mechanisms in response to persistent organic pollutants exposure
期刊论文
OAI收割
SCIENCE OF THE TOTAL ENVIRONMENT, 2019, 卷号: 669, 页码: 621-630
作者:
Zhang, Wanglong
;
Xie, Heidi Qunhui
;
Li, Yunping
  |  
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2020/10/21
Pollution adaptation
POPs toxicology
Comparative transcriptomics
Gene family expansion
Aryl-hydrocarbon receptor
CYP3A
Comparative transcriptomic analysis provides insights into the response to the benzo(a)pyrene stress in aquatic firefly (Luciola leii)
期刊论文
OAI收割
SCIENCE OF THE TOTAL ENVIRONMENT, 2019, 卷号: 661, 页码: 226-234
作者:
Zhang, Qi-Lin
;
Guo, Jun
;
Deng, Xian-Yu
;
Wang, Feng
;
Chen, Jun-Yuan (陈均远)
  |  
收藏
  |  
浏览/下载:97/0
  |  
提交时间:2019/05/22
Luciola Leii Larvae
Transcriptomics
Gene Expression
Benzo(a)Pyrene
Molecular Toxicology
Rna Sequencing