中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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上海药物研究所 [35]
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Discovery of GPX4 inhibitors through FP-based high-throughput screening
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 265, 页码: 14
作者:
Cao, Yu
;
Wu, Bin
;
Xu, Ying
;
Wang, Mingchen
;
Wu, Xinyu
  |  
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2024/02/27
GPX4 inhibitor
HTS assay
Ferroptosis
Fluorescence polarization
Multi-compound and drug-combination pharmacokinetic research on Chinese herbal medicines
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2022, 卷号: 43, 期号: 12, 页码: 3080-3095
作者:
Li, Chuan
;
Jia, Wei-wei
;
Yang, Jun-ling
;
Cheng, Chen
;
Olaleye, Olajide E.
  |  
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2024/03/21
Chinese herbal medicine
pharmacokinetics
multi-compound pharmacokinetic research
drug-combination pharmacokinetic research
pharmacokinetic compatibility
Simultaneous determination of almonertinib and its active metabolite HAS-719 in human plasma by LC-MS/MS: Evaluation of pharmacokinetic interactions
期刊论文
OAI收割
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2022, 卷号: 1197, 页码: 7
作者:
  |  
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2022/08/16
Almonertinib
LC -MS
MS
Active metabolite (HAS-719)
Pharmacokinetic drug-drug interaction
Itraconazole and rifampicin, as CYP3A modulators but not P-gp modulators, affect the pharmacokinetics of almonertinib and active metabolite HAS-719 in healthy volunteers
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 9
作者:
Liu, Lu
;
Li, Wei
;
Yang, Le
;
Guo, Zi-tao
;
Xue, Hao
  |  
收藏
  |  
浏览/下载:46/0
  |  
提交时间:2021/08/17
almonertinib
itraconazole
rifampicin
drug metabolism
drug interaction
CYP3A
P-gp
pharmacokinetics
Polyoxypregnanes as safe, potent, and specific ABCB1-inhibitory pro-drugs to overcome multidrug resistance in cancer chemotherapy in vitro and in vivo
期刊论文
OAI收割
ACTA PHARMACEUTICA SINICA B, 2021, 卷号: 11, 期号: 7, 页码: 1885-1902
作者:
Wu, Xu
;
Yin, Chun
;
Ma, Jiang
;
Chai, Stella
;
Zhang, Chunyuan
  |  
收藏
  |  
浏览/下载:43/0
  |  
提交时间:2021/11/04
Multidrug resistance
ABCB1
Polyoxypregnane
Combination chemotherapy
Marsdenia tenacissima
Pharmacokinetic Drug-drug Interaction of Antibiotics Used in Sepsis Care in China
期刊论文
OAI收割
CURRENT DRUG METABOLISM, 2021, 卷号: 22, 期号: 1, 页码: 5-23
作者:
Yu, Xuan
;
Chu, Zixuan
;
Li, Jian
;
He, Rongrong
;
Wang, Yaya
  |  
收藏
  |  
浏览/下载:95/0
  |  
提交时间:2021/05/24
Pharmacokinetics
drug-drug interaction
antibiotic
sepsis
transporter
enzyme
肿瘤、肠器官芯片的构建及壳寡糖活性评价
学位论文
OAI收割
: 中国科学院大学, 2020
作者:
荆柏林
  |  
收藏
  |  
浏览/下载:53/0
  |  
提交时间:2021/09/07
壳寡糖,器官芯片,肿瘤转移模型,蠕动大肠模型
Effects of Apatinib on the Pharmacokinetics of Nifedipine and Warfarin in Patients with Advanced Solid Tumors
期刊论文
OAI收割
DRUG DESIGN DEVELOPMENT AND THERAPY, 2020, 卷号: 14, 页码: 1963-1970
作者:
Zhu, Yun-Ting
;
Teng, Zan
;
Zhang, Yi-Fan
;
Li, Wei
;
Guo, Li-Xia
  |  
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2020/07/01
apatinib
drug-drug interaction
CYP3A4
CYP2C9
nifedipine
warfarin
Design, synthesis and biological evaluation of bromophenol-thiazolylhydrazone hybrids inhibiting the interaction of translation initiation factors eIF4E/eIF4G as multifunctional agents for cancer treatment
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 177, 页码: 153-170
作者:
Wang, Lijun
;
Guo, Chuanlong
;
Li, Xiuxue
;
Yu, Xuemin
;
Li, Xiangqian
  |  
收藏
  |  
浏览/下载:184/0
  |  
提交时间:2019/08/29
Bromophenol-thiazolylhydrazone hybrids
Synthesis
Multifunctional agents
eIF4E/eIF4G interaction
Autophagy
ROS
High degree of pharmacokinetic compatibility exists between the five-herb medicine XueBiJing and antibiotics comedicated in sepsis care
期刊论文
OAI收割
ACTA PHARMACEUTICA SINICA B, 2019, 卷号: 9, 期号: 5, 页码: 1035-1049
作者:
Li, Jian
;
Olaleye, Olajide E.
;
Yu, Xuan
;
Jia, Weiwei
;
Yang, Junling
  |  
收藏
  |  
浏览/下载:34/0
  |  
提交时间:2020/07/01
XueBiJing
Antibiotic
Combination drug therapy
Sepsis
Pharmacokinetic compatibility
Herb-drug interaction