中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
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上海药物研究所 [11]
大连化学物理研究所 [6]
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浏览/检索结果:
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ABPP-CoDEL: Activity-Based Proteome Profiling-Guided Discovery of Tyrosine-Targeting Covalent Inhibitors from DNA-Encoded Libraries
期刊论文
OAI收割
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2023, 卷号: 145, 期号: 46, 页码: 25283-25292
作者:
Jiang, Lulu
;
Liu, Sixiu
;
Jia, Xinglong
;
Gong, Qinting
;
Wen, Xin
  |  
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2024/01/16
Celastrol suppresses colorectal cancer via covalent targeting peroxiredoxin 1
期刊论文
OAI收割
Signal Transduction and Targeted Therapy, 2023, 卷号: 8, 期号: 3, 页码: 1159-1174
作者:
Xu, Heng
;
Zhao, Hongfang
;
Ding, Chunyong
;
Jiang, Defang
;
Zhao, Zijie
  |  
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2024/03/27
Chemo- and Site-Selective Lysine Modification of Peptides and Proteins under Native Conditions Using the Water-Soluble Zolinium
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2022, 页码: 14
作者:
Sun, Haiguo
;
Xi, Mengyu
;
Jin, Qiang
;
Zhu, Zhengdan
;
Zhang, Yani
  |  
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2022/09/30
Site-specific protein modification by 3-n-butylphthalide in primary hepatocytes: Covalent protein adducts diminished by glutathione and N-acetylcysteine
期刊论文
OAI收割
LIFE SCIENCES, 2021, 卷号: 287, 页码: 14
作者:
Xue, Yaru
;
Ren, Xuelian
;
Zhu, Zhengdan
;
Lei, Peng
;
Liu, Mengling
  |  
收藏
  |  
浏览/下载:48/0
  |  
提交时间:2022/01/18
3-n-butylphthalide
Hepatotoxicity
Oxidative stresses
Covalent protein modification
Drug-drug interaction
Inhibition of Autophagy by a Small Molecule through Covalent Modification of the LC3 Protein
期刊论文
OAI收割
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2021, 页码: 11
作者:
Fan, Shijie
;
Yue, Liyan
;
Wan, Wei
;
Zhang, Yuanyuan
;
Zhang, Bidong
  |  
收藏
  |  
浏览/下载:98/0
  |  
提交时间:2021/12/16
covalent modification
probes
proteome
LC3
post-translational modification
Dynamics of Post-Translational Modification Inspires Drug Design in the Kinase Family
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 20, 页码: 15111-15125
作者:
Zhang, Huimin
;
He, Jixiao
;
Hu, Guang
;
Zhu, Fei
;
Jiang, Hao
  |  
收藏
  |  
浏览/下载:55/0
  |  
提交时间:2022/01/04
Drug design targeting active posttranslational modification protein isoforms
期刊论文
OAI收割
MEDICINAL RESEARCH REVIEWS, 2021, 卷号: 41, 期号: 3, 页码: 1701-1750
作者:
Meng, Fanwang
;
Liang, Zhongjie
;
Zhao, Kehao
;
Luo, Cheng
  |  
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2024/03/22
Allosteric Inhibitor
Covalent Inhibitor
Posttranslational Modifications
Precision Medicine
Protac Protein Degradation
Protein‐
Protein Interactions
Ptm Protein Isoforms
Rational Drug Design
The Chloroplast Epitranscriptome: Factors, Sites, Regulation, and Detection Methods
期刊论文
OAI收割
GENES, 2021, 卷号: 12, 期号: 8
作者:
Manavski, Nikolay
;
Vicente, Alexandre
;
Chi, Wei
;
Meurer, Jorg
  |  
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2023/02/24
chloroplast
RNA metabolism
epitranscriptome
RNA methylation
posttranscriptional regulation
development
acclimation
stress response
Synthesis and structure-activity relationship studies of LLY-507 analogues as SMYD2 inhibitors
期刊论文
OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2020, 卷号: 30, 期号: 22, 页码: 5
作者:
Zhang, Bin
;
Liao, Liping
;
Wu, Fan
;
Zhang, Fengcai
;
Sun, Zhongya
  |  
收藏
  |  
浏览/下载:35/0
  |  
提交时间:2021/05/24
SMYD2 inhibitors
Thermal shift assay
Structure-activity relationships
Characterization of covalent protein modification by triclosan in vivo and in vitro via three-dimensional liquid chromatography-mass spectrometry: New insight into its adverse effects
期刊论文
OAI收割
ENVIRONMENT INTERNATIONAL, 2020, 卷号: 136, 页码: 10
作者:
Liu, Meixian
;
Li, Na
;
Zhang, Yida
;
Zheng, Zhiyuan
;
Zhuo, Yue
  |  
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2020/10/04
Triclosan
Adverse effects
Reactive metabolites
Covalent protein modification
In vivo
Three-dimensional-liquid chromatography-mass spectrometry