中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
机构
上海药物研究所 [11]
生态环境研究中心 [3]
地球环境研究所 [2]
金属研究所 [1]
深圳先进技术研究院 [1]
西北高原生物研究所 [1]
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OAI收割 [23]
iSwitch采集 [1]
内容类型
期刊论文 [21]
学位论文 [3]
发表日期
2024 [1]
2022 [4]
2021 [3]
2020 [1]
2018 [1]
2017 [2]
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学科主题
Toxicology [1]
波谱分析 [1]
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Metabolism investigation of the peptide-drug conjugate LN005 in rats using UHPLC-HRMS
期刊论文
OAI收割
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2024, 卷号: 238, 页码: 11
作者:
Wang, Weiqiang
;
Chen, Chong
;
Luo, Jing
;
Tang, Chongzhuang
;
Zheng, Yuandong
  |  
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2024/01/16
LN005
Metabolism
Peptide -drug conjugates
UHPLC-HRMS
Doxorubicin
Absorption, distribution, metabolism, and excretion of [C-14]Mefuparib (CVL218), a novel PARP1/2 inhibitor, in rats
期刊论文
OAI收割
CANCER CHEMOTHERAPY AND PHARMACOLOGY, 2022, 页码: 12
作者:
Li, Xin-mei
;
Zheng, Yuan-dong
;
Zhang, Yi-fan
;
Huan, Xia-juan
;
Yang, Chen
  |  
收藏
  |  
浏览/下载:30/0
  |  
提交时间:2022/12/13
[C-14]Mefuparib
Mefuparib (CVL218)
Blood-brain barrier
Mass balance
Tissue distribution
GastroPlus simulation
Mechanistic Study on the Species Differences in Excretion Pathway of HR011303 in Humans and Rats
期刊论文
OAI收割
DRUG METABOLISM AND DISPOSITION, 2022, 卷号: 50, 期号: 6, 页码: 809-818
作者:
Guo, Zitao
;
Liu, Mengling
;
Meng, Jian
;
Xue, Yaru
;
Huang, Qi
  |  
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2022/08/16
Pharmacokinetics, Mass Balance, and Metabolism of the Novel Urate Transporter 1 Inhibitor [14C]HR011303 in Humans: Metabolism Is Mediated Predominantly by UDP-Glucuronosyltransferase
期刊论文
OAI收割
DRUG METABOLISM AND DISPOSITION, 2022, 卷号: 50, 期号: 6, 页码: 798-808
作者:
Zheng, Yuandong
;
Zhang, Hua
;
Liu, Mengling
;
Li, Guangze
;
Ma, Sheng
  |  
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2022/08/16
Characterization of microbiome and metabolite analyses in patients with metabolic associated fatty liver disease and type II diabetes mellitus
期刊论文
OAI收割
BMC MICROBIOLOGY, 2022, 卷号: 22
作者:
Yang, Qiuping
;
Zhang, Leisheng
;
Li, Qian
;
Gu, Man
;
Qu, Qiu
  |  
收藏
  |  
浏览/下载:40/0
  |  
提交时间:2022/05/16
Metabolic associated fatty liver disease (MAFLD)
Type II diabetes mellitus (T2DM)
Gut microbiota
Metabolome
Clinical diagnosis
Absorption, distribution, metabolism, and excretion of [C-14]NBP (3-n-butylphthalide) in rats
期刊论文
OAI收割
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2021, 卷号: 1181, 页码: 9
作者:
Tian, Junjun
;
Lei, Peng
;
He, Yifei
;
Zhang, Ning
;
Ge, Xinyu
  |  
收藏
  |  
浏览/下载:51/0
  |  
提交时间:2021/11/04
3-n-butylphthalide (NBP)
[C-14]NBP
Pharmacokinetics
Tissue distribution
Metabolism
Mass balance
Effects of Food on the Pharmacokinetic Properties and Mass Balance of Henagliflozin in Healthy Male Volunteers
期刊论文
OAI收割
CLINICAL THERAPEUTICS, 2021, 卷号: 43, 期号: 9, 页码: E264-E273
作者:
Chen, Zhen-dong
;
Chen, Qian
;
Zhu, Yun-ting
;
Zhang, Yi-fan
;
Zhan, Yan
  |  
收藏
  |  
浏览/下载:46/0
  |  
提交时间:2022/01/04
henagliflozin
food effects
mass balance
pharmacokinetics
SGLT-2 inhibitor
UPLC-ESI-Q-TOF/MS Based Metabolic Profiling of Protosappanin B in Rat Plasma, Bile, Feces, Urine and Intestinal Bacteria Samples
期刊论文
OAI收割
CURRENT DRUG METABOLISM, 2021, 卷号: 22, 期号: 6, 页码: 491-499
作者:
Chen, Wei-Ying
;
Liang, Guang-Yan
;
Zheng, Zuo-Liang
;
Wu, Yun-Shan
;
Xu, Fang-Fang
  |  
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2021/11/04
Protosappanin B
Metabolic pathways
UPLC-TOF-MS
MS
Plasma
Bile
Feces
Urine
Intestinal bacteria sample
Pharmacokinetics, mass balance, and metabolism of [C-14]vicagrel, a novel irreversible P2Y(12) inhibitor in humans
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2020, 页码: 12
作者:
Zheng, Yuan-dong
;
Zhang, Hua
;
Zhan, Yan
;
Bian, Yi-cong
;
Ma, Sheng
  |  
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2021/05/24
vicagrel
[C-14]vicagrel
vicagrel pharmacokinetics
vicagrel metabolism
mass balance
P2Y(12) receptor inhibitor
Environmental toxicants impair liver and kidney function and sperm qualityof captive pandas
期刊论文
OAI收割
Ecotoxicology and Environmental Safety, 2018, 卷号: 162, 期号: 2018, 页码: 218-224
作者:
Chen, Yiping
;
Zhao,Y(Zhao,Yan)
;
Ellison,Aaron M
;
Lorraine Maltby
;
Ma, QY(Ma,Qingyi)
  |  
收藏
  |  
浏览/下载:37/0
  |  
提交时间:2018/09/28
Environment Pollutants
Health Effects
Heavy Metals
Pops
Environmental Toxins
Giant Panda