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浏览/检索结果: 共215条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择提交时间升序提交时间降序发表日期升序发表日期降序题名升序题名降序作者升序作者降序 Development of Potent MALT1 Inhibitors Featuring a Novel "2-Thioxo-2,3-dihydrothiazolo[4,5-d]pyrimidin-7(6H)-one" Scaffold for the Treatment of B Cell Lymphoma 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 67, 期号: 4, 页码: 2884-2906 作者:  Liang, Xuewu;  Yu, Haolan;  Liang, Renwen;  Feng, Zhuanghui;  Saidahmatov, Abdusaid   |  收藏  |  浏览/下载：15/0  |  提交时间：2024/04/09 Discovery and Mechanism Study of SARS-CoV-2 3C-like Protease Inhibitors with a New Reactive Group 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2023, 页码: 18 作者:  Ren, Pengxuan;  Li, Hui;  Nie, Tianqing;  Jian, Xiaoqin;  Yu, Changyue   |  收藏  |  浏览/下载：9/0  |  提交时间：2023/10/17 Structure-Based Design of Potent Peptidomimetic Inhibitors Covalently Targeting SARS-CoV-2 Papain-like Protease 期刊论文  OAI收割 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 卷号: 24, 期号: 10, 页码: 15 作者:  Wang, Qian;  Chen, Guofeng;  He, Jian;  Li, Jiameng;  Xiong, Muya   |  收藏  |  浏览/下载：18/0  |  提交时间：2023/10/17 SARS-CoV-2  papain-like protease  covalent inhibitor  co-crystal structure  in vitro assay   Unraveling the catalytic mechanism of SARS-CoV-2 papain-like protease with allosteric modulation of C270 mutation using multiscale computational approaches 期刊论文  OAI收割 CHEMICAL SCIENCE, 2023, 卷号: 14, 期号: 18, 页码: 4681-4696 作者:  Shao, Qiang;  Xiong, Muya;  Li, Jiameng;  Hu, Hangchen;  Su, Haixia   |  收藏  |  浏览/下载：0/0  |  提交时间：2024/03/27 Discovery and mechanism of action of Thonzonium bromide from an FDA-approved drug library with potent and broad-spectrum inhibitory activity against main proteases of human coronaviruses 期刊论文  OAI收割 BIOORGANIC CHEMISTRY, 2023, 卷号: 130, 页码: 11 作者:  Wang, Ruyu;  Zhai, Guanglei;  Zhu, Guanghao;  Wang, Mengge;  Gong, Xiaoyi   |  收藏  |  浏览/下载：13/0  |  提交时间：2023/04/10 SARS-CoV-23CLpro  Thonzonium bromide  Mechanism of action  Broad-spectrum inhibitor   Identification of Cysteine 270 as a Novel Site for Allosteric Modulators of SARS-CoV-2 Papain-Like Protease 期刊论文  OAI收割 ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2022, 页码: 10 作者:  Hu, Hangchen;  Wang, Qian;  Su, Haixia;  Shao, Qiang;  Zhao, Wenfeng   |  收藏  |  浏览/下载：11/0  |  提交时间：2023/04/10 Allosteric Modulator  Cysteine 270  Drug Design  Papain-Like Protease  SARS-CoV-2   Structure-based design of a novel inhibitor of the ZIKA virus NS2B/ NS3 protease 期刊论文  OAI收割 BIOORGANIC CHEMISTRY, 2022, 卷号: 128, 页码: 7 作者:  Xiong, Yanchao;  Cheng, Fei;  Zhang, Junyi;  Su, Haixia;  Hu, Hangchen   |  收藏  |  浏览/下载：24/0  |  提交时间：2022/11/11 Zika virus  Fragment -based hit screening  Protein -inhibitor interactions  NS2B  NS3 protease  Crystal structure   Discovery of a Potent and Selective Degrader for USP7 期刊论文  OAI收割 ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2022, 卷号: 61, 期号: 33, 页码: e202204395 作者:  Pei, Yuan;  Fu, Jingfeng;  Shi, Yunkai;  Zhang, Mengmeng;  Luo, Guanghao   |  收藏  |  浏览/下载：9/0  |  提交时间：2024/03/21 Apoptotic Pathway  Mutant p53  p53 Mutant Cancer Cells  PROTAC  USP7 Degrader   Crystal structure of the Rubella virus protease reveals a unique papain-like protease fold 期刊论文  OAI收割 JOURNAL OF BIOLOGICAL CHEMISTRY, 2022, 卷号: 298, 期号: 8, 页码: 13 作者:  Cheong, Ezekiel Ze Ken;  Quek, Jun Ping;  Xin, Liu;  Li, Chaoqiang;  Chan, Jing Yi   |  收藏  |  浏览/下载：19/0  |  提交时间：2023/04/10 Discovery of Potent Small-Molecule USP8 Inhibitors for the Treatment of Breast Cancer through Regulating ERα Expression 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 65, 期号: 13, 页码: 8914-8932 作者:  Tian, Yucheng;  Liu, Kang;  Liu, Ruoyi;  Qiu, Zhixia;  Xu, Yifan   |  收藏  |  浏览/下载：4/0  |  提交时间：2024/03/21