中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
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大连化学物理研究所 [70]
上海药物研究所 [10]
广州生物医药与健康研... [2]
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OAI收割 [87]
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期刊论文 [77]
会议论文 [9]
学位论文 [1]
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2022 [2]
2019 [1]
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物理化学 [13]
药物化学 [2]
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Pharmacokinetics, mass balance, and metabolism of [C-14]TPN171, a novel PDE5 inhibitor, in humans for the treatment of pulmonary arterial hypertension
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2022, 页码: 13
作者:
He, Yi-fei
;
Liu, Yin
;
Yu, Jing-hua
;
Cheng, Huan
;
Odilov, Abdullajon
  |  
收藏
  |  
浏览/下载:31/0
  |  
提交时间:2022/08/16
TPN171
[C-14]TPN171
PDE5 inhibitor
pulmonary arterial hypertension
healthy volunteers
pharmacokinetics
metabolite identification
mass balance
Transcriptome analysis of acute high temperature-responsive genes and pathways in Palaemon gravieri
期刊论文
OAI收割
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY D-GENOMICS & PROTEOMICS, 2022, 卷号: 41, 页码: 13
作者:
Shi, Wenjun
;
Hu, Runhao
;
Wang, Pan
;
Zhao, Ran
;
Shen, Hui
  |  
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2022/08/10
Palaemon gravieri
Transcriptome
Acute high temperature
Metabolism
Immunity
Per- and polyfluoroalkyl substances display structure-dependent inhibition towards UDP-glucuronosyltransferases
期刊论文
OAI收割
ENVIRONMENTAL POLLUTION, 2019, 卷号: 254, 页码: -
作者:
Liu, Yong-Zhe
;
Zhang, Zhi-Peng
;
Fu, Zhi-Wei
;
Yang, Kun
;
Ding, Ning
  |  
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2020/09/10
Per- and polyfluoroalkyl substances (PFASs)
UDP-Glucuronosyltransferases (UGTs)
Half inhibition concentration (IC50)
Inhibition type
Inhibition kinetic parameters (Ki)
In vitro-in vivo extrapolation (IVIVE)
Pharmacokinetics-Based Identification of Potential Therapeutic Phthalides from XueBiJing, a Chinese Herbal Injection Used in Sepsis Management
期刊论文
OAI收割
DRUG METABOLISM AND DISPOSITION, 2018, 卷号: 46, 期号: 6, 页码: 823-834
作者:
Zhang, Nating
;
Cheng, Chen
;
Olaleye, Olajide E.
;
Sun, Yan
;
Li, Li
  |  
收藏
  |  
浏览/下载:38/0
  |  
提交时间:2019/01/08
Pharmacokinetics and disposition of anlotinib, an oral tyrosine kinase inhibitor, in experimental animal species
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2018, 卷号: 39, 期号: 6, 页码: 1048-1063
作者:
Zhong, Chen-chun
;
Chen, Feng
;
Yang, Jun-ling
;
Jia, Wei-wei
;
Li, Li
  |  
收藏
  |  
浏览/下载:41/0
  |  
提交时间:2019/01/08
anlotinib
tyrosine kinase inhibitor
absorption
distribution
metabolism
excretion
pharmacokinetics
New Insights into SN-38 Glucuronidation: Evidence for the Important Role of UDP Glucuronosyltransferase 1A9
期刊论文
OAI收割
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY, 2018, 卷号: 122, 期号: 4, 页码: 424-428
作者:
Xiao, Ling
;
Zhu, Liangliang
;
Li, Wenjuan
;
Li, Conghu
;
Cao, Yunfeng
  |  
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2019/06/20
Amentoflavone is a potent broad-spectrum inhibitor of human UDP-glucuronosyltransferases
期刊论文
OAI收割
CHEMICO-BIOLOGICAL INTERACTIONS, 2018, 卷号: 284, 页码: 48-55
作者:
Lv, Xia
;
Zhang, Jian-Bin
;
Wang, Xin-Xin
;
Hu, Wen-Zhong
;
Shi, Yu-Sheng
  |  
收藏
  |  
浏览/下载:35/0
  |  
提交时间:2019/06/20
Amentoflavone
Udp-glucuronosyltransferases
Broad-spectrum Inhibitor
Herb-drug Interactions (Hdis)
Disposition of Mianserin and Cyclizine in UGT2B10-Overexpressing Human Embryonic Kidney 293 Cells: Identification of UGT2B10 as a Novel N-Glucosidation Enzyme and Breast Cancer Resistance Protein as an N-Glucoside Transporter
期刊论文
OAI收割
Drug Metabolism and Disposition, 2018
作者:
Danyi Lu
;
Dong Dong
;
Qian Xie
;
Zhijie Li
;
Baojian Wu
  |  
收藏
  |  
浏览/下载:34/0
  |  
提交时间:2019/01/31
Identification and characterization of human UDP-glucuronosyltransferases responsible for xanthotoxol glucuronidation
期刊论文
OAI收割
XENOBIOTICA, 2018, 卷号: 48, 期号: 2, 页码: 109-116
作者:
Troberg, Johanna
;
Lv, Xia
;
Xia, Yang-Liu
;
Zhu, Liang-Liang
;
He, Guiyuan
  |  
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2019/06/20
Intestinal Glucuronidation
Udp-glucuronosyltransferases
Xanthotoxol
pharmacokineticsanddispositionofanlotinibanoraltyrosinekinaseinhibitorinexperimentalanimalspecies
期刊论文
OAI收割
actapharmacologicasinica, 2018, 卷号: 039, 期号: 006, 页码: 1048
作者:
Zhong Chenchun
;
Chen Feng
;
Yang Junling
;
Jia Weiwei
;
Li Li
  |  
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2020/07/01
酷氨酸
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动物种类
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血浆蛋白质
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CYP3A