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Pharmacokinetics,mass balance,and metabolism of 14C TPN171,a novel PDE5 inhibitor,in humans for the treatment of pulmonary arterial hypertension 期刊论文  OAI收割
ACTA PHARMACOLOGICA SINICA, 2023, 卷号: 44, 期号: 1, 页码: 221
作者:  He Yifei;  Liu Yin;  Yu Jinghua;  Cheng Huan;  Odilov Abdullajon
  |  收藏  |  浏览/下载：15/0  |  提交时间：2023/05/22
Pharmacokinetics, mass balance, and metabolism of [C-14]TPN171, a novel PDE5 inhibitor, in humans for the treatment of pulmonary arterial hypertension 期刊论文  OAI收割
ACTA PHARMACOLOGICA SINICA, 2022, 页码: 13
作者:  He, Yi-fei;  Liu, Yin;  Yu, Jing-hua;  Cheng, Huan;  Odilov, Abdullajon
  |  收藏  |  浏览/下载：31/0  |  提交时间：2022/08/16
A distinctive ligand recognition mechanism by the human vasoactive intestinal polypeptide receptor 2 期刊论文  OAI收割
NATURE COMMUNICATIONS, 2022, 卷号: 13, 期号: 1, 页码: 10
作者:  Xu, Yingna;  Feng, Wenbo;  Zhou, Qingtong;  Liang, Anyi;  Li, Jie
  |  收藏  |  浏览/下载：32/0  |  提交时间：2022/06/15
A Phase I Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of TPN171H, a Novel Phosphodiesterase Type 5 Inhibitor, in Healthy Subjects 期刊论文  OAI收割
DRUG DESIGN DEVELOPMENT AND THERAPY, 2021, 卷号: 15, 页码: 2947-2959
作者:  Qian, Hongjie;  Chen, Qian;  Lang, Liyu;  Zou, Yang;  Pu, Huahua
  |  收藏  |  浏览/下载：17/0  |  提交时间：2021/08/17
Targeted Drugs for Treatment of Pulmonary Arterial Hypertension: Past, Present, and Future Perspectives 期刊论文  OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 63, 期号: 24, 页码: 15153-15186
作者:  Zheng, Wei;  Wang, Zhen;  Jiang, Xiangrui;  Zhao, Qingjie;  Shen, Jingshan
  |  收藏  |  浏览/下载：26/0  |  提交时间：2021/05/24
Metabolomics reveals metabolite changes of patients with pulmonary arterial hypertension in China 期刊论文  OAI收割
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2020, 页码: 13
作者:  Chen, Chenyang;  Luo, Fei;  Wu, Panyun;  Huang, Yiyuan;  Das, Avash
  |  收藏  |  浏览/下载：25/0  |  提交时间：2020/03/18
Characterization of TPN171 metabolism in humans via ultra-performance liquid chromatography/quadrupole time-of-flight Checir for mass spectrometry 期刊论文  OAI收割
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2019, 卷号: 172, 页码: 302-310
作者:  Pan, Lulu;  Guo, Shuang;  Chen, Xiaoyan;  Jiang, Xiangrui;  Shen, Jingshan
  |  收藏  |  浏览/下载：29/0  |  提交时间：2020/07/01
Pharmacokinetics-Driven Optimization of 4(3H)-Pyrimidinones as Phosphodiesterase Type 5 Inhibitors Leading to TPN171, a Clinical Candidate for the Treatment of Pulmonary Arterial Hypertension 期刊论文  OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 62, 期号: 10, 页码: 4979-4990
作者:  Wang, Zhen;  Jiang, Xiangrui;  Zhang, Xianglei;  Tian, Guanghui;  Yang, Rulei
  |  收藏  |  浏览/下载：37/0  |  提交时间：2020/07/01
Pharmacokinetics-Driven Optimization of 4(3H)-Pyrimidinones as Phosphodiesterase Type 5 Inhibitors Leading to TPN171, a Clinical Candidate for the Treatment of Pulmonary Arterial Hypertension 期刊论文  OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 62, 期号: 10, 页码: 4979-4990
作者:  Wang, Z (Wang, Zhen)[ 1 ];  Jiang, XR (Jiang, Xiangrui)[ 1 ];  Zhang, XL (Zhang, Xianglei)[ 1,2 ];  Tian, GH (Tian, Guanghui)[ 3 ];  Yang, RL (Yang, Rulei)[ 3 ]
  |  收藏  |  浏览/下载：133/0  |  提交时间：2019/06/28
Macrophage-Derived Legumain Promotes Pulmonary Hypertension by Activating the MMP (Matrix Metalloproteinase)-2/TGF (Transforming Growth Factor)-beta 1 Signaling 期刊论文  OAI收割
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2019, 卷号: 39, 期号: 4, 页码: E130-E145
作者:  Bai, Peiyuan;  Wan, Naifu;  Lyu, Ankang;  Yu, Tingting;  Lyu, Luheng
  |  收藏  |  浏览/下载：34/0  |  提交时间：2020/12/09