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浏览/检索结果: 共67条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择提交时间升序提交时间降序发表日期升序发表日期降序题名升序题名降序作者升序作者降序 Discovery and mechanism of action of Thonzonium bromide from an FDA-approved drug library with potent and broad-spectrum inhibitory activity against main proteases of human coronaviruses 期刊论文  OAI收割 BIOORGANIC CHEMISTRY, 2023, 卷号: 130, 页码: 11 作者:  Wang, Ruyu;  Zhai, Guanglei;  Zhu, Guanghao;  Wang, Mengge;  Gong, Xiaoyi   |  收藏  |  浏览/下载：13/0  |  提交时间：2023/04/10 SARS-CoV-23CLpro  Thonzonium bromide  Mechanism of action  Broad-spectrum inhibitor   Design and exploration of gut-restricted bifunctional molecule with TGR5 agonistic and DPP4 inhibitory effects for treating ulcerative colitis 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 242, 页码: 114697 作者:  Han, Fanghui;  Ning, Mengmeng;  Wang, Kai;  Gu, Yipei;  Qu, Hui   |  收藏  |  浏览/下载：12/0  |  提交时间：2024/03/21 Bifunctional molecule  Gut-restricted  Ulcerative colitis  TGR5  DPP4   Distal mutation V486M disrupts the catalytic activity of DPP4 by affecting the flap of the propeller domain 期刊论文  OAI收割 ACTA PHARMACOLOGICA SINICA, 2021, 页码: 9 作者:  Li, Teng-teng;  Peng, Cheng;  Wang, Ji-qiu;  Xu, Zhi-jian;  Su, Ming-bo   |  收藏  |  浏览/下载：65/0  |  提交时间：2022/01/18 DPP4  distal mutation  enzymatic activity  molecular dynamics simulation  structure-function mechanism   Design, Synthesis and SAR Studies of Novel and Potent Dipeptidyl Peptidase 4 Inhibitors 期刊论文  OAI收割 CHINESE JOURNAL OF CHEMISTRY, 2021, 卷号: 39, 期号: 1, 页码: 115-120 作者:  Luo, Na;  Fang, Xiaoyu;  Su, Mingbo;  Zhang, Xinwen;  Li, Dan   |  收藏  |  浏览/下载：11/0  |  提交时间：2024/03/21 Type II diabetes  Dipeptidyl peptidase IV  Inhibitors  Molecular docking  Structure‐ activity relationship   Dipeptidyl peptidase 4 inhibitor sitagliptin protected against dextran sulfate sodium-induced experimental colitis by potentiating the action of GLP-2 期刊论文  OAI收割 ACTA PHARMACOLOGICA SINICA, 2020, 页码: 11 作者:  Ning, Meng-meng;  Yang, Wen-ji;  Guan, Wen-bo;  Gu, Yi-pei;  Feng, Ying   |  收藏  |  浏览/下载：22/0  |  提交时间：2020/07/01 ulcerative colitis  dextran sulfate sodium  dipeptidyl peptidase 4  sitagliptin  glucagon-like peptide-2  GLP-2(3-33)  apoptosis  proliferation   基于α-葡萄糖苷酶的降糖苦瓜三萜的挖掘 学位论文  OAI收割 2020 作者:  高亚   |  收藏  |  浏览/下载：3/0  |  提交时间：2023/11/02 Discovery of Highly Polar beta-Homophenylalanine Derivatives as Nonsystemic Intestine-Targeted Dipeptidyl Peptidase IV Inhibitors 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 62, 期号: 23, 页码: 10919-10925 作者:  Huang, Fubao;  Ning, Mengmeng;  Wang, Kai;  Liu, Jia;  Guan, Wenbo   |  收藏  |  浏览/下载：20/0  |  提交时间：2020/07/01 Natural Breviscapin, Mangiferin, and a Modified Mangostin Present Inhibitory Effect on Dipeptidyl Peptidase-IV 期刊论文  OAI收割 CHEMISTRYSELECT, 2018, 卷号: 3, 期号: 39, 页码: 10864-10868 作者:  Hou, Bo;  Kuang, Meng-Ting;  Chi, Xiao-Qian;  Li, Jin-Yu;  Yang, Liu   |  收藏  |  浏览/下载：52/0  |  提交时间：2018/12/03 DPP-IV inhibitors  Scutellaria baicalensis  Mango  Natural products  Virtual Screening   A novel non-enzymatic hydrolytic probe for dipeptidyl peptidase IV specific recognition and imaging 期刊论文  OAI收割 CHEMICAL COMMUNICATIONS, 2018, 卷号: 54, 期号: 63, 页码: 8773-8776 作者:  Xing, Jie;  Gong, Qiuyu;  Zhang, Renshuai;  Sun, Shan;  Zou, Ruifen   |  收藏  |  浏览/下载：30/0  |  提交时间：2019/08/27 A novel non-enzymatic hydrolytic probe for dipeptidyl peptidase IV specific recognition and imaging 期刊论文  OAI收割 CHEMICAL COMMUNICATIONS, 2018, 卷号: 54, 期号: 63, 页码: 8773-8776 作者:  Xing, Jie;  Gong, Qiuyu;  Zhang, Renshuai;  Sun, Shan;  Zou, Ruifen   |  收藏  |  浏览/下载：33/0  |  提交时间：2018/12/21