机构

• 上海药物研究所 [27]

采集方式

• OAI收割 [27]

内容类型

• 期刊论文 [27]

发表日期

• 2023 [27]

学科主题

筛选

浏览/检索结果: 共27条，第1-10条 帮助 限定条件 专题：上海药物研究所    第一署名单位    第一作者单位    通讯作者单位    发表日期：2023     条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择题名升序题名降序提交时间升序提交时间降序作者升序作者降序发表日期升序发表日期降序 Discovery of a novel GPR35 agonist with high and equipotent species potency for oral treatment of IBD 期刊论文  OAI收割 BIOORGANIC & MEDICINAL CHEMISTRY, 2023, 卷号: 96, 页码: 12 作者:  Song, Zhaoxiang;  Lu, Dan;  Sun, Jun;  Ye, Yangliang;  Fang, Jiahui   |  收藏  |  浏览/下载：28/0  |  提交时间：2024/01/16 GPR35  IBD  Lodoxamide   Preclinical and early clinical studies of a novel compound SYHA1813 that efficiently crosses the blood-brain barrier and exhibits potent activity against glioblastoma 期刊论文  OAI收割 ACTA PHARMACEUTICA SINICA B, 2023, 卷号: 13, 期号: 12, 页码: 4748-4764 作者:  Liu, Yingqiang;  Zhan, Zhengsheng;  Kang, Zhuang;  Li, Mengyuan;  Lv, Yongcong   |  收藏  |  浏览/下载：9/0  |  提交时间：2024/01/26 Small molecule inhibitor  Tumor microenvironment  Immune-checkpoint  immune-deficient mouse models  including temozolomide (TMZ) insensitive tumors. Notably   Structure-based drug discovery of novel fused- pyrazolone carboxamide derivatives as potent and selective AXL inhibitors 期刊论文  OAI收割 ACTA PHARMACEUTICA SINICA B, 2023, 卷号: 13, 期号: 12, 页码: 4918-4933 作者:  Fang, Feifei;  Dai, Yang;  Wang, Hao;  Ji, Yinchun;  Liang, Xuewu   |  收藏  |  浏览/下载：7/0  |  提交时间：2024/01/26 derivatives  Antitumor drug development  Potential AXL inhibitor  Antitumor activity  Structure-based drug design  Fused-pyrazolone carboxamide   Original Research Response to programmed cell death protein 1 antibody in patients with Epstein-Barr virus-associated intrahepatic cholangiocarcinoma 期刊论文  OAI收割 EUROPEAN JOURNAL OF CANCER, 2023, 卷号: 194, 页码: 9 作者:  He, Wen-Zhuo;  Huang, Yu-Hua;  Hu, Wan-Ming;  Wang, Fang;  Xu, Yu-Xia   |  收藏  |  浏览/下载：10/0  |  提交时间：2023/12/11 Epstein-Barr virus  Intrahepatic cholangiocarcinoma  Programmed cell death protein 1  Immunotherapy   Ligand activation mechanisms of human KCNQ2 channel 期刊论文  OAI收割 Nature communications, 2023, 卷号: 14, 期号: 1, 页码: 6632 作者:  Ma, Demin;  Zheng, Yueming;  Li, Xiaoxiao;  Zhou, Xiaoyu;  Yang, Zhenni   |  收藏  |  浏览/下载：18/0  |  提交时间：2024/03/26 Discovery of Potent and Selective CB2 Agonists Utilizing a Function-Based Computational Screening Protocol 期刊论文  OAI收割 ACS CHEMICAL NEUROSCIENCE, 2023, 卷号: 14, 期号: 21, 页码: 3941-3958 作者:  Ge, Haixia;  Ji, Beihong;  Fang, Jiahui;  Wang, Jiayang;  Li, Jing   |  收藏  |  浏览/下载：8/0  |  提交时间：2023/12/11 function-based ligand design  receptor-ligandbinding profile  CB1/CB2  structure-activityrelationship   Reversal of subtype-selectivity and function by the introduction of a para-benzamidyl substituent to N-cyclopropylmethyl nornepenthone 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 258, 页码: 15 作者:  Kong, Linghui;  Ning, Kuan;  Liu, Xiao;  Lu, Jiashuo;  Chen, Baiyu   |  收藏  |  浏览/下载：21/0  |  提交时间：2023/10/17 N-cyclopropylmethyl nornepenthone derivatives  derivatives  Structure-activity relationship  MOR antagonist  Functional reversal  Reversal of subtype-selectivity  Opioid use disorder   A pilot study of the differentiated landscape of peripheral blood mononuclear cells from children with incomplete versus complete Kawasaki disease 期刊论文  OAI收割 WORLD JOURNAL OF PEDIATRICS, 2023, 页码: 12 作者:  Sun, Shu-Na;  Zhou, Yan;  Fu, Xing;  Zheng, Yuan-Zheng;  Xie, Cao   |  收藏  |  浏览/下载：15/0  |  提交时间：2023/10/17 Discovery, structural optimization, and anti-tumor bioactivity evaluations of betulinic acid derivatives as a new type of ROR & gamma; antagonists 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 257, 页码: 15 作者:  Mei, Lianghe;  Xu, Lansong   |  收藏  |  浏览/下载：39/0  |  提交时间：2023/10/17 Betulinic acid  ROR & gamma  Target identification  Rationale structure optimization  Anti-tumor effects  antagonists   Hepatic glucuronyl C5-epimerase combats obesity by stabilising GDF15 期刊论文  OAI收割 JOURNAL OF HEPATOLOGY, 2023, 卷号: 79, 期号: 3, 页码: 14 作者:  He, Fei;  Jiang, Haowen;  Peng, Chang;  Wang, Tingting;  Xiao, Rongrong   |  收藏  |  浏览/下载：61/0  |  提交时间：2023/10/17 Glucuronyl C5-epimerase  Growth differentiation factor-15  Obesity  Energy expenditure  Ubiquitination