中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
机构
上海药物研究所 [29]
采集方式
OAI收割 [29]
内容类型
期刊论文 [28]
会议论文 [1]
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2023 [4]
2022 [3]
2021 [2]
2020 [2]
2019 [1]
2018 [4]
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专题:上海药物研究所
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A first-in-human phase 1 study of simnotrelvir, a 3CL-like protease inhibitor for treatment of COVID-19, in healthy adult subjects
期刊论文
OAI收割
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2023, 卷号: 191, 页码: 9
作者:
Yang, Xin-Mei
;
Yang, Yang
;
Yao, Bu-Fan
;
Ye, Pan-Pan
;
Xu, Yan
  |  
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2023/12/11
COVID-19
Simnotrelvir
Safety
Pharmacokinetics
Healthy subjects
Naringenin improves muscle endurance via activation of the Sp1-ERRg transcriptional axis
期刊论文
OAI收割
CELL REPORTS, 2023, 卷号: 42, 期号: 11, 页码: 25
作者:
Lv, Zhenyu
;
Meng, Jiao
;
Yao, Sheng
;
Xiao, Fu
;
Li, Shilong
  |  
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2023/12/11
Glutamine Production by Glul Promotes Thermogenic Adipocyte Differentiation Through Prdm9-Mediated H3K4me3 and Transcriptional Reprogramming
期刊论文
OAI收割
DIABETES, 2023, 卷号: 72, 期号: 11, 页码: 24
作者:
Pan, Xiaowen
;
Ye, Lingxia
;
Guo, Xiaozhen
;
Wang, Weihua
;
Zhang, Ziyin
  |  
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2024/03/25
Further undescribed cembranoids from South China Sea soft coral Sarcophyton ehrenbergi: Structural elucidation and biological evaluation
期刊论文
OAI收割
PHYTOCHEMISTRY, 2023, 卷号: 206, 页码: 9
作者:
Wu, Meng-Jun
;
Yu, Dan-Dan
;
Du, Ye-Qing
;
Zhang, Juan
;
Su, Ming-Zhi
  |  
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2023/04/10
Sarcophyton ehrenbergi
Sarcophytidae
Soft coral
Diterpenoids
Cembranoid
?-Glucosidase inhibitor
Uncommon Capnosane Diterpenes with Neuroprotective Potential from South China Sea Soft Coral Sarcophyton boettgeri
期刊论文
OAI收割
MARINE DRUGS, 2022, 卷号: 20, 期号: 10, 页码: 14
作者:
Du, Ye-Qing
;
Chen, Jing
;
Wu, Meng-Jun
;
Zhang, Hai-Yan
;
Liang, Lin-Fu
  |  
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2022/12/13
soft coral
Sarcophyton boettgeri
capnosane
absolute configuration
neuroprotective effect
Loss of SIRT5 promotes bile acid-induced immunosuppressive microenvironment and hepatocarcinogenesis
期刊论文
OAI收割
JOURNAL OF HEPATOLOGY, 2022, 卷号: 77, 期号: 2, 页码: 453-466
作者:
Sun, Renqiang
;
Zhang, Zhiyong
;
Bao, Ruoxuan
;
Guo, Xiaozhen
;
Gu, Yuan
  |  
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2024/03/21
SIRT5
bile acid
macrophage polarization
immunosuppressive tumor microenvironment
liver cancer
Safety, tolerability, and pharmacokinetics of VV116, an oral nucleoside analog against SARS-CoV-2, in Chinese healthy subjects
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2022, 页码: 9
作者:
Qian, Hong-jie
;
Wang, Yu
;
Zhang, Meng-qi
;
Xie, Yuan-chao
;
Wu, Qing-qing
  |  
收藏
  |  
浏览/下载:37/0
  |  
提交时间:2022/06/15
VV116
nucleoside analog
SARS-CoV-2
safety
pharmacokinetics
healthy subjects
Noreudesmane sesquiterpenoids from Artemisia hedinii and their anti-inflammatory activities
期刊论文
OAI收割
FITOTERAPIA, 2021, 卷号: 153, 页码: 9
作者:
Wang, Xing
;
Tang, Chunping
;
Meng, Suoriya
;
Tang, Bixi
;
Zang, Yi
  |  
收藏
  |  
浏览/下载:45/0
  |  
提交时间:2021/11/04
Artemisia hedinii
Sesquiterpenoid
Dinoreudesmane
Trinoreudesmane
Anti-inflammatory activity
Sleeve gastrectomy ameliorated high-fat diet (HFD)-induced non-alcoholic fatty liver disease and upregulated the nicotinamide adenine dinucleotide +/ Sirtuin-1 pathway in mice
期刊论文
OAI收割
ASIAN JOURNAL OF SURGERY, 2021, 卷号: 44, 期号: 1, 页码: 213-220
作者:
Hua, Rong
;
Wang, Guan-Zhen
;
Shen, Qi-Wei
;
Yang, Ye-Ping
;
Wang, Meng
  |  
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2021/05/24
NAD
NAFLD
NRK1
SIRT1
Sleeve gastrectomy
Disrupting phosphatase SHP2 in macrophages protects mice from high-fat diet-induced hepatic steatosis and insulin resistance by elevating IL-18 levels
期刊论文
OAI收割
JOURNAL OF BIOLOGICAL CHEMISTRY, 2020, 卷号: 295, 期号: 31, 页码: 10842-10856
作者:
Liu, Wen
;
Yin, Ye
;
Wang, Meijing
;
Fan, Ting
;
Zhu, Yuyu
  |  
收藏
  |  
浏览/下载:86/0
  |  
提交时间:2020/12/24
Src homology 2 domain containing tyrosine phosphatase-2 (SHP2)
hepatic steatosis
insulin resistance
caspase-1
interleukin 18 (IL-18)
fatty liver
metabolic disorder
inflammation
cytokine signaling
caspase 1 (CASP1)
tyrosine-protein phosphatase (tyrosine phosphatase)
macrophage