机构

• 上海药物研究所 [14]

采集方式

• OAI收割 [14]

内容类型

• 期刊论文 [14]

发表日期

• 2023 [1]
• 2021 [1]
• 2020 [1]
• 2019 [2]
• 2017 [1]
• 2016 [3]
• 更多

学科主题

筛选

浏览/检索结果: 共14条，第1-10条 帮助 限定条件 专题：上海药物研究所    第一署名单位    第一作者单位    通讯作者单位     条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择提交时间升序提交时间降序发表日期升序发表日期降序题名升序题名降序作者升序作者降序 A RhoA structure with switch II flipped outward revealed the conformational dynamics of switch II region 期刊论文  OAI收割 JOURNAL OF STRUCTURAL BIOLOGY, 2023, 卷号: 215, 期号: 2, 页码: 107942 作者:  Jiang, Hao   |  收藏  |  浏览/下载：5/0  |  提交时间：2024/03/27 Small GTPases  Crystal structures of RhoA  Dynamics of switch II  Molecular dynamics simulations  Allosteric pocket   A 36-week multicenter, randomized, double-blind, placebo-controlled, parallel-group, phase 3 clinical trial of sodium oligomannate for mild-to-moderate Alzheimer’s dementia 期刊论文  OAI收割 Alzheimer's Research & Therapy, 2021, 卷号: 13, 期号: 1 作者:  Xiao,Shifu;  Chan,Piu;  Wang,Tao;  Hong,Zhen;  Wang,Shuzhen   |  收藏  |  浏览/下载：84/0  |  提交时间：2021/05/24 Sodium oligomannate  Efficacy  Safety  Alzheimer’s disease  Clinical trial   Crystallography-guided discovery of carbazole-based retinoic acid-related orphan receptor gamma-t (ROR gamma t) modulators: insights into different protein behaviors with "short" and "long" inverse agonists 期刊论文  OAI收割 ACTA PHARMACOLOGICA SINICA, 2020, 页码: 11 作者:  Yu, Ming-cheng;  Yang, Feng;  Ding, Xiao-yu;  Sun, Nan-nan;  Jiang, Zheng-yuan   |  收藏  |  浏览/下载：93/0  |  提交时间：2020/12/24 RORγ  t  cocrystal structures  MD simulation  “  short”  inverse agonists  agonists  “  long”  inverse agonists   Discovery and biological evaluation of vinylsulfonamide derivatives as highly potent, covalent TEAD autopalmitoylation inhibitors 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 184, 页码: 15 作者:  Lu, Wenchao;  Wang, Jun;  Li, Yong;  Tao, Hongru;  Xiong, Huan   |  收藏  |  浏览/下载：81/0  |  提交时间：2020/07/01 Hippo pathway  TEAD transcription factor  Covalent inhibitor  Palmitoylation inhibitor   Synchrotron radiation micro-tomography for high-resolution neurovascular network morphology investigation 期刊论文  OAI收割 JOURNAL OF SYNCHROTRON RADIATION, 2019, 卷号: 26, 页码: 607-618 作者:  Cao, Yong;  Zhang, Mengqi;  Ding, Hui;  Chen, Zhuohui;  Tang, Bin   |  收藏  |  浏览/下载：28/0  |  提交时间：2020/07/01 high-resolution  imaging  neurovascular network  3D   G9a regulates breast cancer growth by modulating iron homeostasis through the repression of ferroxidase hephaestin 期刊论文  OAI收割 NATURE COMMUNICATIONS, 2017, 卷号: 8 作者:  Wang, Ya-fang;  Zhang, Jie;  Su, Yi;  Shen, Yan-yan;  Jiang, Dong-xian   |  收藏  |  浏览/下载：10/0  |  提交时间：2019/01/08 Small-Molecule Targeting of E3 Ligase Adaptor SPOP in Kidney Cancer 期刊论文  OAI收割 CANCER CELL, 2016, 卷号: 30, 期号: 3, 页码: 474-484 作者:  Guo, Zhong-Qiang;  Zheng, Tong;  Chen, Baoen;  Luo, Cheng;  Ouyang, Sisheng   |  收藏  |  浏览/下载：37/0  |  提交时间：2019/01/08 DW10075, a novel selective and small-molecule inhibitor of VEGFR, exhibits antitumor activities both in vitro and in vivo 期刊论文  OAI收割 ACTA PHARMACOLOGICA SINICA, 2016, 卷号: 37, 期号: 3, 页码: 398-407 作者:  Li, Meng-yuan;  Lv, Yong-cong;  Tong, Lin-jiang;  Peng, Ting;  Qu, Rong   |  收藏  |  浏览/下载：14/0  |  提交时间：2019/01/08 DW10075  VEGF/VEGF receptor inhibitor  antitumor  angiogenesis  U87-MG human glioblastoma   Design, synthesis and biological evaluation of biphenylurea derivatives as VEGFR-2 kinase inhibitors (II) 期刊论文  OAI收割 CHINESE CHEMICAL LETTERS, 2016, 卷号: 27, 期号: 2, 页码: 200-204 作者:  Gao, Guo-Rui;  Li, Meng-Yuan;  Lv, Yong-Cong;  Cao, Su-Fen;  Tong, Lin-Jiang   |  收藏  |  浏览/下载：11/0  |  提交时间：2019/01/08 Angiogenesis  Kinase  Inhibitor  VEGFR-2   Novel tetracyclic benzo[b]carbazolones as highly potent and orally bioavailable ALK inhibitors: Design, synthesis, and structure-activity relationship study 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2015, 卷号: 105, 页码: 39-56 作者:  Jiang, Xiaolong;  Zhou, Ji;  Ai, Jing;  Song, Zilan;  Peng, Xia   |  收藏  |  浏览/下载：60/0  |  提交时间：2019/01/08 Benzo[b]carbazolones  ALK inhibitors  Anti-cancer  Anti-resistance  Non-small-cell lung cancer