中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
机构
上海药物研究所 [12]
采集方式
OAI收割 [12]
内容类型
期刊论文 [12]
发表日期
2023 [2]
2021 [4]
2020 [1]
2019 [1]
2010 [1]
2009 [1]
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专题:上海药物研究所
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Reversal of subtype-selectivity and function by the introduction of a para-benzamidyl substituent to N-cyclopropylmethyl nornepenthone
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 258, 页码: 15
作者:
Kong, Linghui
;
Ning, Kuan
;
Liu, Xiao
;
Lu, Jiashuo
;
Chen, Baiyu
  |  
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2023/10/17
N-cyclopropylmethyl nornepenthone derivatives
derivatives
Structure-activity relationship
MOR antagonist
Functional reversal
Reversal of subtype-selectivity
Opioid use disorder
The PIWI-specific insertion module helps load longer piRNAs for translational activation essential for male fertility
期刊论文
OAI收割
SCIENCE CHINA-LIFE SCIENCES, 2023, 页码: 23
作者:
Wang, Xin
;
Lin, Di-Hang
;
Yan, Yue
;
Wang, An-Hui
;
Liao, Jiaoyang
  |  
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2023/10/17
PIWI
piRNAs
PIWI-Ins
translational activation
spermatid development
male fertility
Amygdalar k-opioid receptor-dependent upregulating glutamate transporter 1 mediates depressive-like behaviors of opioid abstinence
期刊论文
OAI收割
CELL REPORTS, 2021, 卷号: 37, 期号: 5, 页码: 21
作者:
Zan, Gui-Ying
;
Wang, Yu-Jun
;
Li, Xue-Ping
;
Fang, Jun-Fan
;
Yao, Song-Yu
  |  
收藏
  |  
浏览/下载:56/0
  |  
提交时间:2021/12/16
Discovery of SARS-CoV-2-E channel inhibitors as antiviral candidates
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 7
作者:
Wang, Yi
;
Fang, Sui
;
Wu, Yan
;
Cheng, Xi
;
Zhang, Lei-ke
  |  
收藏
  |  
浏览/下载:66/0
  |  
提交时间:2021/08/17
SARS-CoV-2
envelope protein (2-E)
cation channel
high-throughput screening (HTS)
anti-virus
Neolinulicin A and B from Inula japonica and their anti-inflammatory activities
期刊论文
OAI收割
FITOTERAPIA, 2021, 卷号: 152, 页码: 6
作者:
Wu, Rui-fang
;
Zhou, Bing-duo
;
Wang, Wen-qiong
;
Chen, Tong
;
Xu, Ting-ting
  |  
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2021/08/17
Inula japonica
Sesquiterpenes
Anti-inflammation
Anti-inflammatory sesquiterpene dimers and diterpenes from the aerial part of Inula japonica
期刊论文
OAI收割
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, 2021, 页码: 8
作者:
Wu, Rui-Fang
;
Wang, Wen-Qiong
;
Zhou, Bing-Duo
;
Wang, Yi
;
Li, Ya-Ding
  |  
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2021/08/17
Anti-inflammation
composite
ent-kaurane diterpenes
Inula japonica
sesquiterpene dimers
Species differences in the CYP3A-catalyzed metabolism of TPN729, a novel PDE5 inhibitor
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2020, 页码: 9
作者:
Tian, Qian-qian
;
Zhu, Yun-ting
;
Diao, Xing-xing
;
Zhang, Xiang-lei
;
Xu, Ye-chun
  |  
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2020/12/24
PDE5 inhibitor
TPN729
M3
species difference
pharmacokinetics
metabolite identification
Discovery of a Natural-Product-Derived Preclinical Candidate for Once-Weekly Treatment of Type 2 Diabetes
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 62, 期号: 5, 页码: 2348-2361
作者:
Li, Shiliang
;
Qin, Chun
;
Cui, Shichao
;
Xu, Hongling
;
Wu, Fangshu
  |  
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2020/07/01
Magnesium lithospermate B protects cardiomyocytes from ischemic injury via inhibition of TAB1-p38 apoptosis signaling
期刊论文
OAI收割
FRONTIERS IN PHARMACOLOGY, 2010, 卷号: 1
作者:
Du, Chang-Sheng
;
Yang, Rui-Fang
;
Song, Shu-Wei
;
Wang, Yi-Ping
;
Kang, Jiu-Hong
  |  
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2019/01/08
magnesium lithospermate B
ischemia
apoptosis
p38
TAB1
Concise Asymmetric Synthesis of Antimalarial Alkaloid (+)-Febrifugine
期刊论文
OAI收割
SYNLETT, 2009, 期号: 14, 页码: 2301-2304
作者:
Wang, Rui
;
Fang, Kai
;
Sun, Bing-Feng
;
Xu, Ming-Hua
;
Lin, Guo-Qiang
  |  
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2019/01/08
antimalarial
asymmetric synthesis
febrifugine
cross-coupling