机构

• 上海药物研究所 [54]

采集方式

• OAI收割 [54]

内容类型

• 期刊论文 [54]

发表日期

• 2024 [3]
• 2023 [5]
• 2022 [9]
• 2021 [5]
• 2020 [4]
• 2019 [2]
• 更多

学科主题

筛选

浏览/检索结果: 共54条，第1-10条 帮助 限定条件 专题：上海药物研究所    第一署名单位    第一作者单位    通讯作者单位     条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择提交时间升序提交时间降序发表日期升序发表日期降序题名升序题名降序作者升序作者降序 Eliminating drug target interference with specific antibody or its F(ab′)2 fragment in the bridging immunogenicity assay 期刊论文  OAI收割 BIOANALYSIS, 2024, 页码: 14 作者:  Deng, Xiaojie;  Hou, Yingying;  Yuan, Wenyi;  Yang, Hongzhou;  Guo, Ruowen   |  收藏  |  浏览/下载：135/0  |  提交时间：2024/04/09 anti-drug antibody  IgE  immunogenicity  mitigation  target interference   Discovery of a brain-permeable bromodomain and extra terminal domain (BET) inhibitor with selectivity for BD1 for the treatment of multiple sclerosis 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 265, 页码: 14 作者:  Chen, Xuetao;  Wu, Tingting;  Du, Zhiyan;  Kang, Wenjing;  Xu, Rujun   |  收藏  |  浏览/下载：20/0  |  提交时间：2024/02/27 BET  BD1  Bromodomain  Brain-permeable  Multiple sclerosis   Discovery and exploration of novel somatostatin receptor subtype 5 (SSTR5) antagonists for the treatment of cholesterol gallstones 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 264, 页码: 16 作者:  Han, Fanghui;  Zhao, Tingting;  Zhang, Yanglong;  Yun, Ying;  Xu, Yuanyuan   |  收藏  |  浏览/下载：3/0  |  提交时间：2024/02/19 SSTR5 antagonist  Gallbladder emptying  Cholesterol gallstones   Structure-Based Ligand Discovery Targeting the Transmembrane Domain of Frizzled Receptor FZD7 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2023, 页码: 14 作者:  Li, Cuixia;  Wu, Yiran;  Wang, Wenli;  Xu, Lu;  Zhou, Yan   |  收藏  |  浏览/下载：14/0  |  提交时间：2023/10/17 D3CARP: a comprehensive platform with multiple-conformation based docking, ligand similarity search and deep learning approaches for target prediction and virtual screening 期刊论文  OAI收割 COMPUTERS IN BIOLOGY AND MEDICINE, 2023, 卷号: 164, 页码: 8 作者:  Shi, Yulong;  Zhang, Xinben;  Yang, Yanqing;  Cai, Tingting;  Peng, Cheng   |  收藏  |  浏览/下载：21/0  |  提交时间：2023/10/17 Target prediction  Virtual screening  Molecular docking  Ligand similarity search  Deep learning   Discovery of 2-Aminopyrimidine Derivatives as Potent Dual FLT3/CHK1 Inhibitors with Significantly Reduced hERG Inhibitory Activities 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2023, 页码: 23 作者:  Li, Xuemei;  Wang, Peipei;  Wang, Chang;  Jin, Tingting;  Xu, Ran   |  收藏  |  浏览/下载：14/0  |  提交时间：2023/10/17 Discovery of Novel 5,6-Dihydro-1,2,4-triazine Derivatives as Efficacious Glucagon-Like Peptide-1 Receptor Agonists 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2023, 页码: 23 作者:  Chen, Lili;  Yun, Ying;  Guo, Shimeng;  Wang, Xiaoyan;  Xiong, Muya   |  收藏  |  浏览/下载：9/0  |  提交时间：2023/10/17 Cryo-EM structures of orphan GPR21 signaling complexes 期刊论文  OAI收割 NATURE COMMUNICATIONS, 2023, 卷号: 14, 期号: 1, 页码: 1 作者:  Xi Lin;  Bo Chen;  Yiran Wu;  Yingqi Han;  Ao Qi   |  收藏  |  浏览/下载：15/0  |  提交时间：2023/05/22 D3AI-Spike: A deep learning platform for predicting binding affinity between SARS-CoV-2 spike receptor binding domain with multiple amino acid mutations and human angiotensin-converting enzyme 2 期刊论文  OAI收割 COMPUTERS IN BIOLOGY AND MEDICINE, 2022, 卷号: 151, 页码: 8 作者:  Han, Jiaxin;  Liu, Tingting;  Zhang, Xinben;  Yang, Yanqing;  Shi, Yulong   |  收藏  |  浏览/下载：15/0  |  提交时间：2023/04/10 D3AI-Spike  ELISA  Protein -protein interaction  COVID-19  Deep learning   Self-Cooperative Prodrug Nanovesicles Migrate Immune Evasion to Potentiate Chemoradiotherapy in Head and Neck Cancer 期刊论文  OAI收割 ADVANCED SCIENCE, 2022, 页码: 13 作者:  Zhu, Yun;  Zhang, Shunan;  Lai, Yi;  Pan, Jiaxing;  Chen, Fangmin   |  收藏  |  浏览/下载：24/0  |  提交时间：2022/12/13 chemoradiotherapy  cooperative therapy  head and neck cancer  immune evasion  immunogenic cell death