机构

• 上海药物研究所 [35]
• 宁波材料技术与工程研... [2]
• 深圳先进技术研究院 [1]
• 苏州纳米技术与纳米仿... [1]
• 成都生物研究所 [1]
• 上海生物化学与细胞生... [1]
• 更多

采集方式

• OAI收割 [41]

内容类型

• 期刊论文 [40]
• 会议论文 [1]

发表日期

• 2024 [1]
• 2023 [3]
• 2022 [4]
• 2021 [5]
• 2020 [2]
• 2019 [4]
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学科主题

• Biochemist... [1]
• Cell Biolo... [1]
• Chemistry [1]
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• Toxicology [1]

筛选

浏览/检索结果: 共41条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择提交时间升序提交时间降序发表日期升序发表日期降序题名升序题名降序作者升序作者降序 Inulin-like polysaccharide ABWW may impede CCl4 induced hepatic stellate cell activation through mediating the FAK/PI3K/AKT signaling pathway in vitro & in vivo 期刊论文  OAI收割 CARBOHYDRATE POLYMERS, 2024, 卷号: 326, 页码: 15 作者:  Dai, Xiaolan;  Du, Zhenyun;  Jin, Can;  Tang, Bixi;  Chen, Xia   |  收藏  |  浏览/下载：11/0  |  提交时间：2024/02/19 Fructan  Hepatic fibrosis  Hepatic stellate cells  FAK/PI3K/AKT   Structural insights into the interaction of three Y- shaped ligands with PI3Kα 期刊论文  OAI收割 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2023, 卷号: 120, 期号: 34, 页码: 9 作者:  Zhou, Qingtong;  Liu, Xiao;  Neri, Dario;  Li, Wenxin;  Favalli, Nicholas   |  收藏  |  浏览/下载：8/0  |  提交时间：2023/12/08 phosphoinositide 3-kinase  drug target  ligand  binding pocket  chemical scaffold   Discovery of 4-oxo-4,5-dihydropyrazolo[1,5-a]quinoxaline-7-carboxamide derivatives as PI3K alpha inhibitors via virtual screening and docking-based structure optimization 期刊论文  OAI收割 BIOORGANIC & MEDICINAL CHEMISTRY, 2023, 卷号: 86, 页码: 15 作者:  Gu, Dongyan;  Zhang, Mengmeng;  Cai, Lvtao;  Wang, Chang;  Zhou, Yu -Bo   |  收藏  |  浏览/下载：7/0  |  提交时间：2023/10/17 PI3K alpha inhibitors  Virtual screening  Structure optimization   Intact regulation of G1/S transition renders esophageal squamous cell carcinoma sensitive to PI3Kα inhibitors 期刊论文  OAI收割 SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2023, 卷号: 8, 期号: 1, 页码: 153 作者:  Zhang, Xu   |  收藏  |  浏览/下载：3/0  |  提交时间：2024/03/27 Targeting PI3K alpha overcomes resistance to KRas(G12C) inhibitors mediated by activation of EGFR and/or IGF1R 期刊论文  OAI收割 ACTA PHARMACOLOGICA SINICA, 2022, 页码: 12 作者:  Qi, Wei-liang;  Li, Hui-yu;  Wang, Yi;  Xu, Lan;  Deng, Jie-ting   |  收藏  |  浏览/下载：15/0  |  提交时间：2023/04/10 AMG510  KRas(G12C)  PI3K  drug resistance  combination therapy   Cryo-EM structures of cancer-specific helical and kinase domain mutations of PI3K alpha 期刊论文  OAI收割 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2022, 卷号: 119, 期号: 46, 页码: 11 作者:  Liu, Xiao;  Zhou, Qingtong;  Hart, Jonathan R.;  Xu, Yingna;  Yang, Su   |  收藏  |  浏览/下载：16/0  |  提交时间：2023/10/17 phosphoinositide 3-kinase (PI3K)  mass spectrometry  mutants   Genome-wide gain-of-function screening identifies EZH2 mediating resistance to PI3K alpha inhibitors in oesophageal squamous cell carcinoma 期刊论文  OAI收割 CLINICAL AND TRANSLATIONAL MEDICINE, 2022, 卷号: 12, 期号: 5, 页码: 17 作者:  Xing, Hui;  Gao, Mengshi   |  收藏  |  浏览/下载：47/0  |  提交时间：2022/08/16 CDKNIA  cell cycle  CRISPR-SAM  CYH33  ESCC  EZH2  PI3K alpha inhibitor  resistance   Repressing MYC by targeting BET synergizes with selective inhibition of PI3K alpha against B cell lymphoma 期刊论文  OAI收割 CANCER LETTERS, 2022, 卷号: 524, 页码: 206-218 作者:  Chen, Zi-qi;  Cao, Zhe-rui;  Wang, Yi;  Zhang, Xi;  Xu, Lan   |  收藏  |  浏览/下载：54/0  |  提交时间：2021/12/16 CYH33  MYC  P300  BET  B cell lymphoma  PI3K   SAF-248, a novel PI3K delta-selective inhibitor, potently suppresses the growth of diffuse large B-cell lymphoma 期刊论文  OAI收割 ACTA PHARMACOLOGICA SINICA, 2021, 页码: 11 作者:  Zhang, Xi;  Duan, Yu-ting;  Wang, Yi;  Zhao, Xing-dong;  Sun, Yi-ming   |  收藏  |  浏览/下载：53/0  |  提交时间：2021/05/24 PI3Kδ  PI3K  AKT  mTOR  diffuse large B-cell lymphoma  resistance  combination therapy   Adaptive resistance to PI3K alpha-selective inhibitor CYH33 is mediated by genomic and transcriptomic alterations in ESCC cells 期刊论文  OAI收割 CELL DEATH & DISEASE, 2021, 卷号: 12, 期号: 1, 页码: 13 作者:  Wang, Yu-xiang;  Zhang, Xu;  Ma, Qing-yang;  Hu, Lan-dian;  Zhang, Xi   |  收藏  |  浏览/下载：42/0  |  提交时间：2021/05/24