机构

• 上海药物研究所 [24]
• 西北高原生物研究所 [11]
• 生态环境研究中心 [3]
• 大连化学物理研究所 [2]
• 上海有机化学研究所 [2]
• 南海海洋研究所 [1]
• 更多

采集方式

• OAI收割 [48]
• iSwitch采集 [1]

内容类型

• 期刊论文 [48]
• 学位论文 [1]

发表日期

• 2024 [1]
• 2023 [3]
• 2022 [2]
• 2021 [2]
• 2020 [1]
• 2019 [3]
• 更多

学科主题

• Chemistry [1]
• Chemistry,... [1]
• Chemistry,... [1]
• Chemistry,... [1]
• Pharmacolo... [1]
• 有机化学 [1]
• 更多

筛选

浏览/检索结果: 共49条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择提交时间升序提交时间降序发表日期升序发表日期降序题名升序题名降序作者升序作者降序 Discovery and optimization of thieno[3,2-d]pyrimidine derivatives as highly selective inhibitors of cyclin-dependent kinase 7 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 263, 页码: 21 作者:  Zhang, Hongjin;  Lin, Guohao;  Jia, Suyun;  Zhang, Ying;  Wu, Jianbo   |  收藏  |  浏览/下载：5/0  |  提交时间：2024/01/26 Thieno[3  d ]pyrimidine derivative  Cyclin-dependent kinase 7  Small molecule inhibitor  Kinome selectivity  Triple negative breast cancer   Design and synthesis of 1H-pyrazolo[3,4-d]pyrimidine derivatives as hematopoietic progenitor kinase 1 (HPK1) inhibitors 期刊论文  OAI收割 BIOORGANIC CHEMISTRY, 2023, 卷号: 140, 页码: 18 作者:  Zhang, Junjie;  Li, Yan;  Tang, Haotian;  Zhou, Qianqian;  Tong, Linjiang   |  收藏  |  浏览/下载：8/0  |  提交时间：2023/12/08 Cancer immunotherapy  HPK1  Structure -based design  HPK1 inhibitor   Discovery of 7H-Pyrrolo[2,3-d]pyrimidine Derivatives as potent hematopoietic progenitor kinase 1 (HPK1) inhibitors 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 254, 页码: 15 作者:  Wu, Feifei;  Li, Huiyu;  An, Qi;  Sun, Yaoliang;  Yu, Jinghua   |  收藏  |  浏览/下载：9/0  |  提交时间：2023/10/17 Hematopoietic progenitor kinase 1 (HPK1)  Cancer immunotherapy  Inhibitor  T cell   Application of deep generative model for design of Pyrrolo[2,3-d] pyrimidine derivatives as new selective TANK binding kinase 1 (TBK1) inhibitors 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 247, 页码: 115034 作者:  Song, Shukai;  Tang, Haotian;  Ran, Ting;  Fang, Feng;  Tong, Linjiang   |  收藏  |  浏览/下载：1/0  |  提交时间：2024/03/27 SyntaLinker  Generative modelling  TBK1 inhibitor  pyrrolo[2  3-d]pyrimidine  Structure-activity relationship   Discovery of Pyrrolo[2,3-d]pyrimidine derivatives as potent and selective colony stimulating factor 1 receptor kinase inhibitors 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 243 作者:  Liang, Xiaofei;  Wang, Chun;  Wang, Beilei;  Liu, Juan;  Qi, Shuang   |  收藏  |  浏览/下载：38/0  |  提交时间：2022/12/23 CSF1R inhibitor  Kinase inhibitor  Macrophage polarization   Discovery of Novel Pyrrolo[2,3-d]pyrimidine-based Derivatives as Potent JAK/HDAC Dual Inhibitors for the Treatment of Refractory Solid Tumors 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 65, 期号: 2, 页码: 1243-1264 作者:  Liang, Xuewu;  Tang, Shuai;  Liu, Xuyi;  Liu, Yingluo;  Xu, Qifu   |  收藏  |  浏览/下载：38/0  |  提交时间：2022/06/15 Discovery and structure - activity relationship exploration of pyrazolo [1,5-a]pyrimidine derivatives as potent FLT3-ITD inhibitors 期刊论文  OAI收割 BIOORGANIC & MEDICINAL CHEMISTRY, 2021, 卷号: 48, 页码: 13 作者:  Chen, Yun;  Bai, Gang;  Li, Yan;  Ning, Yi;  Cao, Sufen   |  收藏  |  浏览/下载：57/0  |  提交时间：2021/12/01 FLT3  FLT3-ITD  Acute myeloid leukemia  Structure-activity relationships  Pyrazolo[1, 5-a]pyrimidine   Discovery of pyrrolo[2,3-d]pyrimidine derivatives as potent Axl inhibitors: Design, synthesis and biological evaluation 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 220, 页码: 18 作者:  Xu, Dandan;  Sun, Deqiao;  Wang, Wei;  Peng, Xia;  Zhan, Zhengsheng   |  收藏  |  浏览/下载：38/0  |  提交时间：2021/08/17 Axl  Cancer  Inhibitor  Pyrrolo[2,3-d]pyrimidine   Synthesis of fused-tetrahydropyrimidines: one-pot methylenation-cyclization utilizing two molecules of CO2 期刊论文  OAI收割 ORGANIC & BIOMOLECULAR CHEMISTRY, 2020, 卷号: 18, 期号: 35 作者:  Zhao, Yulei;  Guo, Xuqiang;  Du, Yulan;  Shi, Xinrui;  Yan, Shina   |  收藏  |  浏览/下载：26/0  |  提交时间：2020/11/25 Design, synthesis, and biological evaluation of thieno[3,2-d]pyrimidine derivatives as potential simplified phosphatidylinositol 3-kinase alpha inhibitors 期刊论文  OAI收割 CHEMICAL BIOLOGY & DRUG DESIGN, 2019, 卷号: 94, 期号: 6, 页码: 2013-2022 作者:  Yang, Xiuyan;  Deng, Meng;  Zhang, Xi;  Wang, Yi;  Song, Kun   |  收藏  |  浏览/下载：31/0  |  提交时间：2020/07/01 PI3K alpha inhibitors  proliferation inhibition  thieno[3  2-d]pyrimidine derivatives