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• 西北高原生物研究所 [84]
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• 中国科学院大学 [6]
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• OAI收割 [248]
• iSwitch采集 [8]

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• 期刊论文 [254]
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• 2024 [1]
• 2023 [7]
• 2022 [13]
• 2021 [25]
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浏览/检索结果: 共256条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择提交时间升序提交时间降序发表日期升序发表日期降序题名升序题名降序作者升序作者降序 A novel strategy for treating oncogene-mutated tumors by targeting tumor microenvironment and synergistically enhancing anti-PD-1 immunotherapy 期刊论文  OAI收割 CANCER COMMUNICATIONS, 2024, 页码: 5 作者:  Liu, Yingqiang;  Tong, Linjiang;  Zhang, Mengge;  Zhang, Qi;  Liu, Qiupei   |  收藏  |  浏览/下载：13/0  |  提交时间：2024/03/13 Preclinical and early clinical studies of a novel compound SYHA1813 that efficiently crosses the blood-brain barrier and exhibits potent activity against glioblastoma 期刊论文  OAI收割 ACTA PHARMACEUTICA SINICA B, 2023, 卷号: 13, 期号: 12, 页码: 4748-4764 作者:  Liu, Yingqiang;  Zhan, Zhengsheng;  Kang, Zhuang;  Li, Mengyuan;  Lv, Yongcong   |  收藏  |  浏览/下载：9/0  |  提交时间：2024/01/26 Small molecule inhibitor  Tumor microenvironment  Immune-checkpoint  immune-deficient mouse models  including temozolomide (TMZ) insensitive tumors. Notably   Design and synthesis of 1H-pyrazolo[3,4-d]pyrimidine derivatives as hematopoietic progenitor kinase 1 (HPK1) inhibitors 期刊论文  OAI收割 BIOORGANIC CHEMISTRY, 2023, 卷号: 140, 页码: 18 作者:  Zhang, Junjie;  Li, Yan;  Tang, Haotian;  Zhou, Qianqian;  Tong, Linjiang   |  收藏  |  浏览/下载：8/0  |  提交时间：2023/12/08 Cancer immunotherapy  HPK1  Structure -based design  HPK1 inhibitor   DZ2002 alleviates corneal angiogenesis and inflammation in rodent models of dry eye disease via regulating STAT3-PI3KAkt-NF-kappa B pathway 期刊论文  OAI收割 ACTA PHARMACOLOGICA SINICA, 2023, 页码: 14 作者:  Wu, Chun-mei;  Mao, Jia-wen;  Zhu, Jin-zhi;  Xie, Can-can;  Yao, Jia-ying   |  收藏  |  浏览/下载：14/0  |  提交时间：2023/10/17 dry eye disease  DZ2002  corneal angiogenesis  immunomodulatory function  NF-kappa B  ophthalmic therapy   Artificial intelligence-based computer-aided diagnosis system supports diagnosis of lymph node metastasis in esophageal squamous cell carcinoma: A multicenter study 期刊论文  OAI收割 HELIYON, 2023, 卷号: 9, 期号: 3, 页码: 11 作者:  Zhang, Shuai-Tong;  Wang, Si-Yun;  Zhang, Jie;  Dong, Di;  Mu, Wei   |  收藏  |  浏览/下载：8/0  |  提交时间：2023/11/16 Esophageal squamous cell carcinoma  PET/CT  Lymph node metastasis  Artificial intelligence   Effect of layer charge density and cation concentration on sorption behaviors of heavy metal ions in the interlayer and nanopore of montmorillonite: A molecular dynamics simulation 期刊论文  OAI收割 COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 2023, 卷号: 657, 期号: -, 页码: - 作者:  Zhang, Wei;  Li, Jiang-Shan;  Chen, Shan-Xiong;  Huang, Kang;  Luo, Li-Jiao   |  收藏  |  浏览/下载：5/0  |  提交时间：2023/08/02 Interlayer and nanopore  Layer charge  Cation ?s concentration  Montmorillonite  Molecular dynamics simulations   Design, synthesis and biological evaluation of KRASG12C-PROTACs 期刊论文  OAI收割 BIOORGANIC & MEDICINAL CHEMISTRY, 2023, 卷号: 78, 页码: 14 作者:  Zhang, Xiaoyi;  Zhao, Tong;  Sun, Minghao;  Li, Pei;  Lai, Mengzhen   |  收藏  |  浏览/下载：13/0  |  提交时间：2023/04/10 KRASG12C  PROTAC  Covalent inhibitors  Structure-activity relationships (SARs)  Anticancer   Discovery of HCD3514 as a potent EGFR inhibitor against C797S mutation in vitro and in vivo 期刊论文  OAI收割 JOURNAL OF CANCER, 2023, 卷号: 14, 期号: 1, 页码: 152-162 作者:  Lai, Mengzhen;  Zhang, Tao;  Chen, Hao;  Song, Peiran;  Tong, Linjiang   |  收藏  |  浏览/下载：80/0  |  提交时间：2023/04/10 fourth-generation EGFR inhibitor  EGFRC797S mutation  NSCLC  drug resistance  small molecular inhibitor   ASK120067 potently suppresses B-cell or T-cell malignancies in vitro and in vivo by inhibiting BTK and ITK 期刊论文  OAI收割 FRONTIERS IN PHARMACOLOGY, 2022, 卷号: 13, 页码: 9 作者:  Song, Peiran;  Bai, Gang;  Chan, Shingpan;  Zhang, Tao;  Tong, Linjiang   |  收藏  |  浏览/下载：27/0  |  提交时间：2023/04/10 Bruton's tyrosine kinase  interleukin-2-inducible T cell kinase  ASK120067  B-cell lymphoma  T-cell leukemia   Loss of SIRT5 promotes bile acid-induced immunosuppressive microenvironment and hepatocarcinogenesis 期刊论文  OAI收割 JOURNAL OF HEPATOLOGY, 2022, 卷号: 77, 期号: 2, 页码: 453-466 作者:  Sun, Renqiang;  Zhang, Zhiyong;  Bao, Ruoxuan;  Guo, Xiaozhen;  Gu, Yuan   |  收藏  |  浏览/下载：12/0  |  提交时间：2024/03/21 SIRT5  bile acid  macrophage polarization  immunosuppressive tumor microenvironment  liver cancer