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上海药物研究所 [100]
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Catalytic site flexibility facilitates the substrate and catalytic promiscuity of Vibrio dual lipase/transferase
期刊论文
OAI收割
NATURE COMMUNICATIONS, 2023, 卷号: 14, 期号: 1, 页码: 11
作者:
Wang, Chongyang
;
Liu, Changshui
;
Zhu, Xiaochuan
;
Peng, Quancai
;
Ma, Qingjun
  |  
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2023/12/13
Structural analysis of the dual agonism at GLP-1R and GCGR
期刊论文
OAI收割
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2023, 卷号: 120, 期号: 33, 页码: 12
作者:
Li, Yang
;
Zhou, Qingtong
;
Dai, Antao
;
Zhao, Fenghui
;
Chang, Rulue
  |  
收藏
  |  
浏览/下载:0/0
  |  
提交时间:2024/05/07
glucagon-like peptide-1 receptor
glucagon receptor
cryo-electron microscopy
dual agonism
Elastic network models and molecular dynamic simulations reveal the molecular basis of allosteric regulation in ubiquitin-specific protease 7 (USP7)
期刊论文
OAI收割
COMPUTERS IN BIOLOGY AND MEDICINE, 2023, 卷号: 162, 页码: 10
作者:
Xu, Jing
  |  
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2023/10/17
USP7
Allosteric regulation
Elastic network models
Molecular dynamics simulations
A hydrogen-deuterium exchange mass spectrometry-based protocol for protein-small molecule interaction analysis
期刊论文
OAI收割
Biophysics reports, 2023, 卷号: 9, 期号: 2, 页码: 99-111
作者:
Meng, Qian
;
Song, Yuan-Li
;
Zhou, Chen
;
He, Han
;
Zhang, Naixia
  |  
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2024/03/26
Modular Biomimetic Strategy Enabled Discovery of Simplified Pseudo-Natural Macrocyclic P-Glycoprotein Inhibitors Capable of Overcoming Multidrug Resistance
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 66, 期号: 4, 页码: 2550-2565
作者:
Liu, Bo
;
Yu, Xueni
;
Liu, Liping
;
Wang, Lei
;
Wang, Jie
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收藏
  |  
浏览/下载:5/0
  |  
提交时间:2024/03/27
Discovery and mechanism of action of Thonzonium bromide from an FDA-approved drug library with potent and broad-spectrum inhibitory activity against main proteases of human coronaviruses
期刊论文
OAI收割
BIOORGANIC CHEMISTRY, 2023, 卷号: 130, 页码: 11
作者:
Wang, Ruyu
;
Zhai, Guanglei
;
Zhu, Guanghao
;
Wang, Mengge
;
Gong, Xiaoyi
  |  
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2023/04/10
SARS-CoV-23CLpro
Thonzonium bromide
Mechanism of action
Broad-spectrum inhibitor
Structural insights into a shared mechanism of human STING activation by a potent agonist and an autoimmune disease-associated mutation
期刊论文
OAI收割
CELL DISCOVERY, 2022, 卷号: 8, 期号: 1, 页码: 17
作者:
Xie, Zuoquan
;
Wang, Zhen
;
Fan, Fengying
;
Zhou, Jinpei
;
Hu, Zhaoxue
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收藏
  |  
浏览/下载:22/0
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提交时间:2023/04/10
An optimization algorithm for conformer generation based on the bond contribution ranking
期刊论文
OAI收割
COMPUTATIONAL BIOLOGY AND CHEMISTRY, 2022, 卷号: 100, 页码: 107751
作者:
Zhang, Ziheng
;
Zhang, Kai
;
Liu, Zhihui
;
Zhao, Jialei
;
Wang, Jing
  |  
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2024/03/21
Conformer generation
Bond contribution rank
Systematic sampling
Torsion angle
Nanobodies and chemical cross-links advance the structural and functional analysis of PI3K alpha
期刊论文
OAI收割
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2022, 卷号: 119, 期号: 38, 页码: 9
作者:
Hart, Jonathan R.
;
Liu, Xiao
;
Pan, Chen
;
Liang, Anyi
;
Ueno, Lynn
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收藏
  |  
浏览/下载:12/0
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提交时间:2023/10/17
phosphoinositide 3-kinase (PI3K)
nanobody
conformational changes
chemical cross-linking
mass spectrometry
Size exclusion chromatography using large pore size media induces adverse conformational changes of inactivated foot-and-mouth disease virus particles
期刊论文
OAI收割
Journal of Chromatography A, 2022, 卷号: 1677
作者:
Song, Yanmin
;
Yang, Yanli
;
Lin, Xuan
;
Zhao, Qizu
;
Su, Zhiguo
  |  
收藏
  |  
浏览/下载:0/0
  |  
提交时间:2023/06/26
Chlorine compounds - Column chromatography - Particle size analysis - Separation - Size exclusion chromatography - Viruses