中国科学院机构知识库网格
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Probing the dynamic thermodynamic resolution and biological activity of Cu(II) and Pd(II) complexes with Schiff base ligand derived from proline
期刊论文
OAI收割
CHINESE CHEMICAL LETTERS, 2024, 卷号: 35, 期号: 4, 页码: 7
作者:
Yu, Tao
;
Soloshonok, Vadim A.
;
Xiao, Zhekai
;
Liu, Hong
;
Wang, Jiang
  |  
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2024/04/09
Schiff bases
Biological activity
Tailor-made amino acids
Asymmetric synthesis
Chiral tridentate ligands
Square-planar Cu(II)-complexes
Square-planar Pd(II)-complexes
Discovery of potent PROTAC degraders of Pin1 for the treatment of acute myeloid leukemia
期刊论文
OAI收割
CHEMICAL SCIENCE, 2024, 卷号: 15, 期号: 13, 页码: 5027-5035
作者:
Shi, Yunkai
;
Liu, Minmin
;
Li, Mengna
;
Mao, Yiwen
;
Ma, Jingkun
  |  
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2024/05/07
A Vancomycin-Templated DNA-Encoded Library for Combating Drug-Resistant Bacteria
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 67, 期号: 5, 页码: 3778-3794
作者:
Guan, Dongliang
;
Liu, Jiaxiang
;
Chen, Feifei
;
Li, Jian
;
Wang, Xiaowen
  |  
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2024/05/07
Discovery and Optimization of WDR5 Inhibitors via Cascade Deoxyribonucleic Acid-Encoded Library Selection Approach
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 67, 期号: 2, 页码: 1079-1092
作者:
Qin, Shaozhao
;
Feng, Lijian
;
Zhao, Qingyi
;
Yan, Ziqin
;
Lyu, Xilin
  |  
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2024/02/27
ABPP-CoDEL: Activity-Based Proteome Profiling-Guided Discovery of Tyrosine-Targeting Covalent Inhibitors from DNA-Encoded Libraries
期刊论文
OAI收割
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2023, 卷号: 145, 期号: 46, 页码: 25283-25292
作者:
Jiang, Lulu
;
Liu, Sixiu
;
Jia, Xinglong
;
Gong, Qinting
;
Wen, Xin
  |  
收藏
  |  
浏览/下载:30/0
  |  
提交时间:2024/01/16
Assessment of the structure-activity relationship and antileukemic activity of diacylpyramide compounds as human ClpP agonists
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 258, 页码: 17
作者:
Zhang, Ranran
;
Wang, Pengyu
;
Wei, Bingyan
;
Chen, Liang
;
Song, Xiaomin
  |  
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2023/10/17
ClpP agonists
Structure-activity relationship
Mitochondrial respiratory chain
Antileukemic therapy
LINC00955 suppresses colorectal cancer growth by acting as a molecular scaffold of TRIM25 and Sp1 to Inhibit DNMT3B-mediated methylation of the PHIP promoter
期刊论文
OAI收割
BMC CANCER, 2023, 卷号: 23, 期号: 1, 页码: 20
作者:
Ren, Ganglin
;
Li, Hongyan
;
Hong, Dan
;
Hu, Fangyu
;
Jin, Rongjia
  |  
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2023/12/08
LINC00955
Colorectal cancer
Cell cycle
CDK2
PHIP
Sp1
DPPA5A suppresses the mutagenic TLS and MMEJ pathways by modulating the cryptic splicing of
Rev1
and
Polq
in mouse embryonic stem cells
期刊论文
OAI收割
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2023, 卷号: 120, 期号: 30, 页码: 11
作者:
Jiang, Fangjie
;
Wang, Lin
;
Dong, Yuping
;
Nie, Wenhui
;
Zhou, Hu
  |  
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2023/12/08
embryonic stem cells
cryptic exon
DPPA5A
Rev1
Polq
Privileged heterocycles for DNA-encoded library design and hit-to-lead optimization
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 248, 页码: 26
作者:
Wen, Xin
;
Wu, Xinyuan
;
Jin, Rui
;
Lu, Xiaojie
  |  
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2023/04/10
DNA Encoded library
Drug discovery
Heterocycles
Hit identification
Lead generation
Chemiluminescence Sensor for miRNA-21 Detection Based on CRISPR-Cas12a and Cation Exchange Reaction
期刊论文
OAI收割
ANALYTICAL CHEMISTRY, 2023, 页码: 8
作者:
Zhou, Yanmei
;
Xie, Shupu
;
Liu, Bo
;
Wang, Cong
;
Huang, Yibo
  |  
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2023/12/13