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• 上海药物研究所 [980]
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• OAI收割 [1979]
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浏览/检索结果: 共2046条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择提交时间升序提交时间降序题名升序题名降序作者升序作者降序发表日期升序发表日期降序 Discovery of YFJ-36: Design, Synthesis, and Antibacterial Activities of Catechol-Conjugated β-Lactams against Gram-Negative Bacteria 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2024, 页码: 21 作者:  Liu, Fangjun;  Kou, Qunhuan;  Li, Hongyuan;  Cao, Yangzhi   |  收藏  |  浏览/下载：0/0  |  提交时间：2024/05/22 DockingGA: enhancing targeted molecule generation using transformer neural network and genetic algorithm with docking simulation 期刊论文  OAI收割 BRIEFINGS IN FUNCTIONAL GENOMICS, 2024, 页码: 12 作者:  Gao, Changnan;  Bao, Wenjie;  Wang, Shuang;  Zheng, Jianyang;  Wang, Lulu   |  收藏  |  浏览/下载：1/0  |  提交时间：2024/05/20 molecule generation  molecule optimization  drug discovery  deep learning  drug design  genetic algorithm   Proteasome activation: A novel strategy for targeting undruggable intrinsically disordered proteins 期刊论文  OAI收割 BIOORGANIC CHEMISTRY, 2024, 卷号: 145, 页码: 17 作者:  Yu, Qian;  Wang, Zheng;  Tu, Yutong;  Cao, Yu;  Zhu, Huajian   |  收藏  |  浏览/下载：0/0  |  提交时间：2024/05/07 20S proteasome  Proteasome activation  IDPs  Undruggable  Protein homeostasis   Discovery and Optimization of Novel Nonbile Acid FXR Agonists as Preclinical Candidates for the Treatment of Inflammatory Bowel Disease 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 67, 期号: 7, 页码: 5642-5661 作者:  Li, Yuan;  Xu, Tingting;  Zhao, Yue;  Zhang, Hui;  Liu, Zesheng   |  收藏  |  浏览/下载：4/0  |  提交时间：2024/05/07 Discovery of potent PROTAC degraders of Pin1 for the treatment of acute myeloid leukemia 期刊论文  OAI收割 CHEMICAL SCIENCE, 2024, 卷号: 15, 期号: 13, 页码: 5027-5035 作者:  Shi, Yunkai;  Liu, Minmin;  Li, Mengna;  Mao, Yiwen;  Ma, Jingkun   |  收藏  |  浏览/下载：6/0  |  提交时间：2024/05/07 Discovery of a Covalent Inhibitor Selectively Targeting the Autophosphorylation Site of c-Src Kinase 期刊论文  OAI收割 ACS CHEMICAL BIOLOGY, 2024, 页码: 12 作者:  Zhang, Huimin;  Xu, Dounan;  Huang, Hongchan;  Jiang, Hao;  Hu, Linghao   |  收藏  |  浏览/下载：1/0  |  提交时间：2024/05/07 Worm-like micelles facilitate the intestinal mucus diffusion and drug accumulation for enhancing colorectal cancer therapy 期刊论文  OAI收割 Chinese Chemical Letters, 2024, 卷号: 35, 期号: 6, 页码: 108967 作者:  Zhou, Yihan;  Gao, Duo;  Wang, Yaying;  Liang, Li;  Zhang, Qingyu   |  收藏  |  浏览/下载：25/0  |  提交时间：2024/03/26 Design and Synthesis of Cyclolipopeptide Mimics of Dysoxylactam A and Evaluation of the Reversing Potencies against P-Glycoprotein-Mediated Multidrug Resistance 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 67, 期号: 6, 页码: 4560-4582 作者:  Yang, Guan-Zhou;  Wang, Lei;  Gao, Kun;  Zhu, Xi;  Lou, Li-Guang   |  收藏  |  浏览/下载：1/0  |  提交时间：2024/05/07 Impact of Halogen Bonds on Protein-Peptide Binding and Protein Structural Stability Revealed by Computational Approaches 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2024, 页码: 11 作者:  Li, Jintian;  Zhou, Liping;  Han, Zijian;  Wu, Leyun;  Zhang, Jianfang   |  收藏  |  浏览/下载：0/0  |  提交时间：2024/05/07 Prevalence and risk factors for abnormal glucose metabolism in first-episode and drug-na?ve major depressive disorder outpatients with comorbid anxiety: A cross-sectional study from a large sample of the Chinese Han population 期刊论文  OAI收割 JOURNAL OF AFFECTIVE DISORDERS, 2024, 卷号: 349, 页码: 400-406 作者:     |  收藏  |  浏览/下载：27/0  |  提交时间：2024/03/25 Major depressive disorder  Glucose disturbances  First -episode drug-naive  Anxiety