中国科学院机构知识库网格
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New chromone derivatives bearing thiazolidine-2,4-dione moiety as potent PTP1B inhibitors: Synthesis and biological activity evaluation
期刊论文
OAI收割
BIOORGANIC CHEMISTRY, 2024, 卷号: 143, 页码: 9
作者:
Zheng, Yingying
;
Lu, Li
;
Li, Mengyue
;
Xu, Dehua
;
Zhang, Laishun
  |  
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2024/01/26
Chromone
Thiazolidine-2
4-dione
Protein tyrosine phosphatase 1B
Inhibitors
Structure-based optimization of indoline-containing compounds as second generation inhibitors of NF-KB-inducing kinase (NIK)
期刊论文
OAI收割
JOURNAL OF MOLECULAR STRUCTURE, 2024, 卷号: 1295, 页码: 19
作者:
Cheng, Jing
;
Yan, Ziqin
;
Li, Xinzhi
;
Liu, Chen
;
Tong, Linjiang
  |  
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2023/12/08
Kinase inhibitor
NIK
NF-KB2
Indoline
COT
Cytotoxicity
Discovery and bioinspired total syntheses of unprecedented sesquiterpenoid dimers unveiled bifurcating [4+2] cycloaddition and target differentiation of enantiomers
期刊论文
OAI收割
CHEMICAL SCIENCE, 2024, 卷号: 15, 期号: 4
作者:
He, Tao-Bin
;
Yan, Bing-Chao
;
Zhou, Yuan-Fei
;
Sang, Yue-Qian
;
Li, Xiao-Nian
  |  
收藏
  |  
浏览/下载:1/0
  |  
提交时间:2024/05/09
DIELS-ALDER REACTION
BIOMIMETIC SYNTHESES
EFFICIENT ACCESS
DEHYDROGENATION
CYCLOHEXANONES
BIOSYNTHESIS
CONVERSION
OXIDATION
DYNAMICS
PHENOLS
Development of PI3Kγ selective inhibitors: the strategies and application
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2023, 页码: 10
作者:
Gu, Dong-Yan
;
Zhang, Meng-Meng
;
Li, Jia
;
Zhou, Yu-Bo
;
Sheng, Rong
  |  
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2023/12/08
PI3K
PI3K gamma inhibitors
isoform selectivity
drug development
rational drug design
Design, synthesis and pharmacological evaluation of 2,3-dihydrobenzo-furan IRAK4 inhibitors for the treatment of diffuse large B-cell lymphoma
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 256, 页码: 16
作者:
Chen, Yun
;
Ning, Yi
;
Chen, Zhiwei
;
Xue, Yaping
;
Wu, Qingyun
  |  
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2023/10/17
Apoptosis
Diffuse large B-Cell lymphoma
Interleukin-1 receptor associated kinase 4
Structure-based drug design
2
3-Dihydrobenzofuran
Structure-based discovery of potent USP28 inhibitors derived from Vismodegib
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 254, 页码: 15
作者:
Zhou, Di
;
Xu, Zhuo
;
Huang, Yaodong
;
Wang, Hui
;
Zhu, Xiaoli
  |  
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2023/10/17
USP28
Structure-based
Vismodegib derivatives
Structure-activity relationships
c-Myc
Insights into the reaction mechanism of toluene oxidation by isotope dynamic experiment and the kinetics over MCeZr/TiO2 (M = Cu, Mn, Ni, Co and Fe) catalysts
期刊论文
OAI收割
FUEL, 2023, 卷号: 341, 页码: 127760
作者:
Zhang, Zirui
;
Hu, Guangtao
;
Zhao, Chenchen
;
Wei XL(魏小林)
;
Dou, Baojuan
  |  
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2023/04/20
Toluene removal
Kinetics
Freeman Carroll
Infrared spectrum
Isotopically labeled oxygen
Design, Synthesis, and Evaluation of (R)-8-((Tetrahydrofuran-2-yl)methyl)pyrido[2,3-d]pyrimidin-7-ones as Novel Selective ACK1 Inhibitors to Combat Acquired Resistance to the Third-Generation EGFR Inhibitor
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2023, 页码: 17
作者:
Li, Qian
;
Zhang, Tao
;
Song, Peiran
;
Tong, Linjiang
;
Feng, Fang
  |  
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2023/10/17
Bioelectrocatalysis for CO2 reduction: recent advances and challenges to develop a sustainable system for CO2 utilization
期刊论文
OAI收割
BIOTECHNOLOGY ADVANCES, 2023, 卷号: 63, 页码: 28
作者:
Luan, Likun
;
Ji, Xiuling
;
Guo, Boxia
;
Cai, Jinde
;
Dong, Wanrong
  |  
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2023/05/19
CO 2 reduction
Bioelectrocatalysis
Electron transfer
Photo-electrocatalysis
Celastrol suppresses colorectal cancer via covalent targeting peroxiredoxin 1
期刊论文
OAI收割
Signal Transduction and Targeted Therapy, 2023, 卷号: 8, 期号: 3, 页码: 1159-1174
作者:
Xu, Heng
;
Zhao, Hongfang
;
Ding, Chunyong
;
Jiang, Defang
;
Zhao, Zijie
  |  
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2024/03/27