机构

• 上海药物研究所 [8]
• 宁波材料技术与工程研... [1]
• 水生生物研究所 [1]
• 自动化研究所 [1]
• 上海生物化学与细胞生... [1]
• 合肥物质科学研究院 [1]
• 更多

采集方式

• OAI收割 [13]

内容类型

• 期刊论文 [12]
• 会议论文 [1]

发表日期

• 2023 [1]
• 2022 [1]
• 2021 [2]
• 2020 [2]
• 2019 [1]
• 2018 [1]
• 更多

学科主题

• Biochemist... [1]
• Cell Biolo... [1]
• Chemistry [1]
• Toxicology [1]

筛选

浏览/检索结果: 共13条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择提交时间升序提交时间降序发表日期升序发表日期降序题名升序题名降序作者升序作者降序 Development of PI3Kγ selective inhibitors: the strategies and application 期刊论文  OAI收割 ACTA PHARMACOLOGICA SINICA, 2023, 页码: 10 作者:  Gu, Dong-Yan;  Zhang, Meng-Meng;  Li, Jia;  Zhou, Yu-Bo;  Sheng, Rong   |  收藏  |  浏览/下载：4/0  |  提交时间：2023/12/08 PI3K  PI3K gamma inhibitors  isoform selectivity  drug development  rational drug design   Peptidic microarchitecture-trapped tumor vaccine combined with immune checkpoint inhibitor or PI3K gamma inhibitor can enhance immunogenicity and eradicate tumors 期刊论文  OAI收割 JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2022, 卷号: 10, 期号: 2, 页码: 13 作者:  Du, Yang;  Liu, Ye;  Wang, Di;  Bai, Hua;  Wang, Zhijie   |  收藏  |  浏览/下载：25/0  |  提交时间：2022/06/06 immunotherapy  immunogenicity  vaccine  tumor microenvironment  lymphocytes  tumor infiltrating  macrophages   Identification of methyl (5-(6-((4-(methylsulfonyl)piperazin-1-yl)methyl)-4-morpholinopyrrolo[2,1-f][1,2,4]triazin-2-yl)-4-(trifluoromethyl)pyridin-2-yl)carbamate (CYH33) as an orally bioavailable, highly potent, PI3K alpha inhibitor for the treatment of advanced solid tumors 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 209, 页码: 10 作者:  Xiang, Hao-Yue;  Wang, Xiang;  Chen, Yan-Hong;  Zhang, Xi;  Tan, Cun   |  收藏  |  浏览/下载：24/0  |  提交时间：2021/05/24 PI3K  Pyrrolo[2,1-f][1,2,4]triazine  Anti-cancer  Target therapy   PI3K alpha inhibitor CYH33 triggers antitumor immunity in murine breast cancer by activating CD8(+)T cells and promoting fatty acid metabolism 期刊论文  OAI收割 JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2021, 卷号: 9, 期号: 8, 页码: 16 作者:  Sun, Pu;  Zhang, Xi;  Wang, Rong-Jing;  Ma, Qing-Yang;  Xu, Lan   |  收藏  |  浏览/下载：23/0  |  提交时间：2021/11/04 tumor microenvironment  immunomodulation  immunologic memory  lymphocytes  tumor-infiltrating  macrophages   Emerging roles of class I PI3K inhibitors in modulating tumor microenvironment and immunity 期刊论文  OAI收割 ACTA PHARMACOLOGICA SINICA, 2020, 页码: 8 作者:  Sun, Pu;  Meng, Ling-hua   |  收藏  |  浏览/下载：21/0  |  提交时间：2020/12/21 phosphoinositide 3-kinase (PI3K)  PI3K inhibitors  tumor microenvironment  immune cells  immunotherapy   Roles of TGF beta 1 in the expression of phosphoinositide 3-kinase isoform genes and sensitivity and response of lung telocytes to PI3K inhibitors 期刊论文  OAI收割 CELL BIOLOGY AND TOXICOLOGY, 2020, 卷号: 36, 期号: 1, 页码: 51-64 作者:  Song, Dongli;  Tang, Li;  Wang, Lu;  Huang, Jianan;  Wang, Xiangdong   |  收藏  |  浏览/下载：25/0  |  提交时间：2020/12/21 MESENCHYMAL STEM-CELLS  AIRWAY EPITHELIAL-CELLS  TGF-BETA  II CELLS  PULMONARY TELOCYTES  CANCER CELLS  FIBROBLASTS  PROLIFERATION   Development of novel chromeno[4,3-c]pyrazol-4(2H)-one derivates containing piperazine as inhibitors of PI3K alpha 会议论文  OAI收割 作者:  Yin, Yong;  Zhou, Yang;  Sha, Shao;  Wu, Xun;  Wang, She-Feng   |  收藏  |  浏览/下载：19/0  |  提交时间：2021/12/02 EMBRYONIC LETHALITY  PATHWAY  KINASE  PI3K  DISCOVERY  3-KINASES  SUBUNIT  GROWTH  POTENT  TARGET   Discovery of (S)-2-amino-N-(5-(6-chloro-5-(3-methylphenylsulfonamido)pyridin-3-yl)-4-methylthiazol-2-yl)-3-methylbutanamide (CHMFL-PI3KD-317) as a potent and selective phosphoinositide 3-kinase delta (PI3K delta) inhibitor 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 156, 页码: 831-846 作者:  Liang, Xiaofei;  Li, Feng;  Chen, Cheng;  Jiang, Zongru;  Wang, Aoli   |  收藏  |  浏览/下载：31/0  |  提交时间：2019/12/10 PI3K delta  Kinase inhibitor  Acute myeloid leukemia  Structure-activity relationship   Pharmacologic characterization of SHR8443, a novel dual inhibitor of phosphatidylinositol 3-kinase and mammalian target of rapamycin 期刊论文  OAI收割 ONCOTARGET, 2017, 卷号: 8, 期号: 64, 页码: 107977-107990 作者:  Xie, Chengying;  Chen, Xiangling;  Zheng, Mingyue;  Liu, Xiaohong;  Wang, Hongbin   |  收藏  |  浏览/下载：27/0  |  提交时间：2019/01/08 BEZ235  drug resistance  mTOR  PI3K  SHR8443   G beta 1 is required for neutrophil migration in zebrafish 期刊论文  OAI收割 DEVELOPMENTAL BIOLOGY, 2017, 卷号: 428, 期号: 1, 页码: 135-147 作者:  Ke, Wenfan;  Ye, Ding;  Mersch, Kacey;  Xu, Hui;  Chen, Songhai   |  收藏  |  浏览/下载：16/0  |  提交时间：2019/09/17 Cell migration  Neutrophil  G protein  G beta 1  Imaging