机构

• 上海药物研究所 [10]
• 大连化学物理研究所 [7]
• 合肥物质科学研究院 [2]
• 化学研究所 [1]
• 上海有机化学研究所 [1]

采集方式

• OAI收割 [20]
• iSwitch采集 [1]

内容类型

• 期刊论文 [21]

发表日期

• 2023 [4]
• 2022 [1]
• 2021 [1]
• 2019 [2]
• 2018 [1]
• 2017 [3]
• 更多

学科主题

• 物理化学 [1]
• 生命有机化学 [1]

筛选

浏览/检索结果: 共21条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择提交时间升序提交时间降序发表日期升序发表日期降序题名升序题名降序作者升序作者降序 Development of PI3Kγ selective inhibitors: the strategies and application 期刊论文  OAI收割 ACTA PHARMACOLOGICA SINICA, 2023, 页码: 10 作者:  Gu, Dong-Yan;  Zhang, Meng-Meng;  Li, Jia;  Zhou, Yu-Bo;  Sheng, Rong   |  收藏  |  浏览/下载：4/0  |  提交时间：2023/12/08 PI3K  PI3K gamma inhibitors  isoform selectivity  drug development  rational drug design   Structural insights into the interaction of three Y- shaped ligands with PI3Kα 期刊论文  OAI收割 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2023, 卷号: 120, 期号: 34, 页码: 9 作者:  Zhou, Qingtong;  Liu, Xiao;  Neri, Dario;  Li, Wenxin;  Favalli, Nicholas   |  收藏  |  浏览/下载：8/0  |  提交时间：2023/12/08 phosphoinositide 3-kinase  drug target  ligand  binding pocket  chemical scaffold   Discovery of selective NaV1.8 inhibitors based on 5-chloro-2-(4,4-difluor- oazepan-1-yl)-6-methyl nicotinamide scaffold for the treatment of pain 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 254, 页码: 12 作者:  Qin, Hui;  Wei, Aihuan;  Wang, Yunqi;  Wang, Linlin;  Xu, Haiyan   |  收藏  |  浏览/下载：14/0  |  提交时间：2023/10/17 Pain  Non-addictive analgesics  Na V 1  8-selective inhibitors  Bicyclic aromatic groups   Discovery of 4-oxo-4,5-dihydropyrazolo[1,5-a]quinoxaline-7-carboxamide derivatives as PI3K alpha inhibitors via virtual screening and docking-based structure optimization 期刊论文  OAI收割 BIOORGANIC & MEDICINAL CHEMISTRY, 2023, 卷号: 86, 页码: 15 作者:  Gu, Dongyan;  Zhang, Mengmeng;  Cai, Lvtao;  Wang, Chang;  Zhou, Yu -Bo   |  收藏  |  浏览/下载：7/0  |  提交时间：2023/10/17 PI3K alpha inhibitors  Virtual screening  Structure optimization   Adjusted degradation of BRD4 S and BRD4 L based on fine structural modifications of the pyrrolopyridone scaffold 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 236, 页码: 14 作者:  Chen, Jingjing;  He, Huixin   |  收藏  |  浏览/下载：23/0  |  提交时间：2022/08/16 PROTAC  Pyrrolopyridone  BRD4 S  Selectivity   Discovery of a subtype-selective, covalent inhibitor against palmitoylation pocket of TEAD3 期刊论文  OAI收割 ACTA PHARMACEUTICA SINICA B, 2021, 卷号: 11, 期号: 10, 页码: 3206-3219 作者:  Lu, Tian;  Li, Yong;  Lu, Wenchao;  Spitters, Twgm;  Fang, Xueyu   |  收藏  |  浏览/下载：45/0  |  提交时间：2021/12/01 Hippo pathway  TEAD3  Covalent inhibitor  Palmitoylation inhibitor   Cytochrome P450 3A Enzymes Are Key Contributors for Hepatic Metabolism of Bufotalin, a Natural Constitute in Chinese Medicine Chansu 期刊论文  OAI收割 FRONTIERS IN PHARMACOLOGY, 2019, 卷号: 10, 页码: 10 作者:  Ma, Hong-Ping;  Dai, Zi-Ru;  Ning, Jing;  Sun, Gui-Bo;  Wang, Ping   |  收藏  |  浏览/下载：65/0  |  提交时间：2019/06/20 bufotalin  cytochrome P450 3A (CYP3A)  hydroxylation  human liver microsomes (HLMs)  docking simulations   Cytochrome p450 3a enzymes are key contributors for hepatic metabolism of bufotalin, a natural constitute in chinese medicine chansu 期刊论文  iSwitch采集 Frontiers in pharmacology, 2019, 卷号: 10, 页码: 10 作者:  Dai, Zi-Ru;  Ning, Jing;  Sun, Gui-Bo;  Wang, Ping;  Zhang, Feng 收藏  |  浏览/下载：87/0  |  提交时间：2019/05/08 Bufotalin  Cytochrome p450 3a (cyp3a)  Hydroxylation  Human liver microsomes (hlms)  Docking simulations   Chemoproteomics reveals baicalin activates hepatic CPT1 to ameliorate diet-induced obesity and hepatic steatosis 期刊论文  OAI收割 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2018, 卷号: 115, 期号: 26, 页码: E5896-E5905 作者:  Dai, Jianye;  Liang, Kai;  Zhao, Shan;  Jia, Wentong;  Liu, Yuan   |  收藏  |  浏览/下载：54/0  |  提交时间：2019/04/09 Baicalin  Cpt1  Obesity  Chemical Proteomics  Steatosis   PI-273, a Substrate-Competitive, Specific Small-Molecule Inhibitor of PI4KII alpha, Inhibits the Growth of Breast Cancer Cells 期刊论文  OAI收割 CANCER RESEARCH, 2017, 卷号: 77, 期号: 22, 页码: 6253-6266 作者:  Li, Jiangmei;  Gao, Zhen;  Zhao, Dan;  Zhang, Lunfeng;  Qiao, Xinhua   |  收藏  |  浏览/下载：24/0  |  提交时间：2019/01/08