机构

• 上海应用物理研究所 [9]
• 上海药物研究所 [7]
• 武汉植物园 [2]
• 合肥物质科学研究院 [2]
• 近代物理研究所 [2]
• 寒区旱区环境与工程研... [1]
• 更多

采集方式

• OAI收割 [24]

内容类型

• 期刊论文 [24]

发表日期

• 2024 [1]
• 2023 [1]
• 2022 [2]
• 2021 [3]
• 2020 [1]
• 2019 [1]
• 更多

学科主题

• Oncology [1]
• Pathology [1]

筛选

浏览/检索结果: 共24条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择题名升序题名降序提交时间升序提交时间降序作者升序作者降序发表日期升序发表日期降序 A novel approach to exploit Small-Molecule glucagon-like Peptide-1 receptor agonists with high potency 期刊论文  OAI收割 BIOORGANIC & MEDICINAL CHEMISTRY, 2024, 卷号: 107, 页码: 19 作者:  Wang, Xiaoyan;  Yun, Ying;  Chen, Lili;  Guo, Shimeng;  Niu, Buying   |  收藏  |  浏览/下载：33/0  |  提交时间：2024/07/12 Diabetes  GLP-1 receptor  Agonist  Structural optimization  Water molecule replacement  Structure activity relationship  Docking simulation   Phenotypic screening-based drug discovery of furan-2-carboxylic acid derivatives for the amelioration of type 2 diabetes mellitus (T2DM) 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 246, 页码: 11 作者:  Chen, Lili;  Huang, Suling;  Ye, Yangliang;  Shen, Yu;  Xu, Tifei   |  收藏  |  浏览/下载：33/0  |  提交时间：2023/04/10 Phenotypic screening  Gluconeogenesis  Furan-2-carboxylic acid  T2DM   Synthesis of AC1903 analogs as potent transient receptor potential canonical channel 4/5 inhibitors and biological evaluation 期刊论文  OAI收割 BIOORGANIC & MEDICINAL CHEMISTRY, 2022, 卷号: 68, 页码: 11 作者:  Chen, Lili;  Zhang, Zhuang;  Tian, Hongtao;  Jiang, Shan;  Ji, Yunyun   |  收藏  |  浏览/下载：41/0  |  提交时间：2022/11/11 TRPC5  AC1903  Podocyte  FSGS  Keratinocyte  Proliferation  Inflammation   Discovery of pyrroledione analogs as potent transient receptor potential canonical channel 5 inhibitors 期刊论文  OAI收割 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2022, 卷号: 61, 页码: 11 作者:  Zhang, Zhuang;  Chen, Lili;  Tian, Hongtao;  Liu, Mengru;  Jiang, Shan   |  收藏  |  浏览/下载：26/0  |  提交时间：2022/06/15 TRPC5  Pyrroledione  FSGS  CKD   Discovery of novel ketoxime ether derivatives with potent FXR agonistic activity, oral effectiveness and high liver/blood ratio 期刊论文  OAI收割 BIOORGANIC & MEDICINAL CHEMISTRY, 2021, 卷号: 43, 页码: 13 作者:  Tang, Xuehang;  Ning, Mengmeng;  Ye, Yangliang;  Gu, Yipei;  Yan, Hongyi   |  收藏  |  浏览/下载：47/0  |  提交时间：2021/11/04 FXR agonist  Ketoxime ether  Target genes  Liver  blood ratio  Systemic activation   Magnetic domains in a uniaxial magnet Dy3Al2 期刊论文  OAI收割 APPLIED PHYSICS LETTERS, 2021, 卷号: 119 作者:  Zu, Lin;  Lyu, Boyao;  Tang, Jin;  Gao, Jianhua;  Liu, Fengguang   |  收藏  |  浏览/下载：54/0  |  提交时间：2021/08/30 Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) 期刊论文  OAI收割 AUTOPHAGY, 2021, 卷号: 17 作者:  Klionsky, Daniel J.;  Abdel-Aziz, Amal Kamal;  Abdelfatah, Sara;  Abdellatif, Mahmoud;  Abdoli, Asghar   |  收藏  |  浏览/下载：319/0  |  提交时间：2021/05/31 Autophagosome  cancer  flux  LC3  lysosome  macroautophagy  neurodegeneration  phagophore  stress  vacuole   Design of G-protein-coupled bile acid receptor 1 (GPBAR1, TGR5) soft drugs with reduced gallbladder-filling effects 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 203, 页码: 12 作者:  Han, Fanghui;  Ning, Mengmeng;  Cao, Hua;  Ye, Yangliang;  Feng, Ying   |  收藏  |  浏览/下载：28/0  |  提交时间：2020/12/21 Soft drug  TGR5  GLP-1  Gallbladder-filling effects  Rapid metabolism  Carboxylic ester   TGR5 agonist ameliorates insulin resistance in skeletal muscles and improves glucose homeostasis in diabetic mice 期刊论文  OAI收割 METABOLISM-CLINICAL AND EXPERIMENTAL, 2019, 卷号: 99, 页码: 45-56 作者:  Huang, Suling;  Ma, Shanyao;  Ning, Mengmeng;  Yang, Wenji;  Ye, Yangliang   |  收藏  |  浏览/下载：39/0  |  提交时间：2020/07/01 TGR5  Glucose homeostasis  Insulin resistance  Skeletal muscle  Type 2 diabetes   HIC1 loss promotes prostate cancer metastasis by triggering epithelial - mesenchymal transition 期刊论文  OAI收割 JOURNAL OF PATHOLOGY, 2017, 卷号: 242, 期号: 4, 页码: 409-420 作者:  Hao, Mingang;  Wang, Yingying;  Sun, Xueqing;  Li, Yue;  Wang, Jinglong   |  收藏  |  浏览/下载：23/0  |  提交时间：2020/12/09 HIC  prostate cancer  EMT  metastasis