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A nanobody-enzyme fusion protein targeting PD-L1 and sialic acid exerts anti-tumor effects by C-type lectin pathway-mediated tumor associated macrophages repolarizing
期刊论文
OAI收割
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2025, 卷号: 298, 页码: 13
作者:
Tong, Yongliang
;
Chen, Runqiu
;
Lu, Xinrong
  |  
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2025/04/01
Glycol-immunology
Nanobody-enzyme fusion protein
Sialic acid
Molecular Imaging of Ovarian Follicles and Tumors With Near-Infrared II Bioconjugates
期刊论文
OAI收割
ADVANCED MATERIALS, 2024, 页码: 13
作者:
Wang, Yicong
;
Lu, Wenhan
;
Chen, Zi-Han
;
Xiao, Yan
;
Wang, Yu
  |  
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2025/02/28
biomaterials
follicular tracking
multi-color imaging
near-infrared II bioconjugates
near-infrared II in vivo imaging
Design and synthesis of novel site-specific antibody-drug conjugates that target TROP2
期刊论文
OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY, 2024, 卷号: 110, 页码: 16
作者:
Luo, Caili
;
Ren, Anni
;
Jin, Zixuan
;
Zhang, Jianxin
;
Shi, Wei
  |  
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2024/08/22
TROP2
Antibody-drug conjugate (ADC)
Site-specific
Glycoengineering
Affinity-directed conjugation
PPIA dictates NRF2 stability to promote lung cancer progression
期刊论文
OAI收割
NATURE COMMUNICATIONS, 2024, 卷号: 15, 期号: 1, 页码: 20
作者:
Lu, Weiqiang
;
Cui, Jiayan
;
Wang, Wanyan
;
Hu, Qian
;
Xue, Yun
  |  
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2024/07/12
Discovery of novel triazine derivatives as potent retinoic acid receptor-related orphan receptor gamma t (ROR gamma t) inverse agonists
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 256, 页码: 18
作者:
Lu, Lixue
;
Chen, Song
;
Yu, Mingcheng
;
Zhou, Ronghui
;
Guo, Siqi
  |  
收藏
  |  
浏览/下载:32/0
  |  
提交时间:2023/10/17
ROR gamma t
Triazines
Inverse agonist
Psoriasis
Autoimmune diseases
Effect of an Herbal-Based Injection on 28-Day Mortality in Patients With Sepsis The EXIT-SEP Randomized Clinical Trial
期刊论文
OAI收割
JAMA INTERNAL MEDICINE, 2023, 卷号: 183, 期号: 7, 页码: 647-655
作者:
Liu, Songqiao
;
Yao, Chen
;
Xie, Jianfeng
;
Liu, Hong
;
Wang, Hongliang
  |  
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2024/03/27
Photochemically controlled activation of STING by CAIX-targeting photocaged agonists to suppress tumor cell growth
期刊论文
OAI收割
CHEMICAL SCIENCE, 2023, 卷号: 14, 期号: 22, 页码: 5956-5964
作者:
Ding, Chunyong
;
Du, Mengyan
;
Xiong, Zhi
;
Wang, Xue
;
Li, Hongji
  |  
收藏
  |  
浏览/下载:36/0
  |  
提交时间:2023/10/17
Optimization of carbazole carboxamide RORγt agonists: Challenges in improving the metabolic stability and maintaining the agonistic activity
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 251, 页码: 115213
作者:
Sun, Nannan
;
Yu, Mingcheng
;
Jiang, Zhengyuan
;
Yang, Feng
;
Lu, Lixue
  |  
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2024/03/27
ROR?t agonists
Carbazole carboxamide
Agonistic activity
Metabolic stability
Co-crystallization
Molecular docking
Human genetic history on the Tibetan Plateau in the past 5100 years
期刊论文
OAI收割
SCIENCE ADVANCES, 2023, 卷号: 9, 期号: 11, 页码: 18
作者:
Wang, Hongru
;
Yang, Melinda A.
;
Wangdue, Shargan
;
Lu, Hongliang
;
Chen, Honghai
  |  
收藏
  |  
浏览/下载:30/0
  |  
提交时间:2023/10/25
Neuroprotective effects of a lead compound from coral via modulation of the orphan nuclear receptor Nurr1
期刊论文
OAI收割
CNS NEUROSCIENCE & THERAPEUTICS, 2022, 页码: 14
作者:
Su, Jian-Wei
;
Yang, Pei
;
Xing, Mei-Mei
;
Chen, Bao
;
Xie, Xia-Hong
  |  
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2023/04/10
C
elegans
corals-derived compounds
neuroprotection
Nurr1
SH-SY5Y cells