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上海药物研究所 [138]
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期刊论文 [112]
会议论文 [32]
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A nanobody-enzyme fusion protein targeting PD-L1 and sialic acid exerts anti-tumor effects by C-type lectin pathway-mediated tumor associated macrophages repolarizing
期刊论文
OAI收割
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2025, 卷号: 298, 页码: 13
作者:
Tong, Yongliang
;
Chen, Runqiu
;
Lu, Xinrong
;
Chen, Cuiying
;
Sun, Guiqin
  |  
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2025/04/01
Glycol-immunology
Nanobody-enzyme fusion protein
Sialic acid
Ligand-binding assays validated for quantitative bioanalysis of a novel antibody-drug conjugate in monkey serum and related application in a nonclinical study
期刊论文
OAI收割
JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS, 2025, 卷号: 131, 页码: 11
作者:
Hou, Yingying
;
Miao, Jie
;
Sun, Yajun
;
Shi, Lili
;
Lu, Ouyang
  |  
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2025/04/01
ADC
LBA
Validation
GLP
PK
Zexie-Baizhu Decoction ameliorates non-alcoholic fatty liver disease through gut-adipose tissue crosstalk
期刊论文
OAI收割
JOURNAL OF ETHNOPHARMACOLOGY, 2025, 卷号: 337, 页码: 14
作者:
Shi, Jingying
;
Liu, Yawen
;
Zhang, Zijia
;
Zhong, Xianchun
;
Cao, Yuhan
  |  
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2024/10/21
Zexie-Baizhu Decoction
Traditional Chinese medicine
Akkermansia muciniphila
Bile acids
Short chain fatty acid
Lipidomics
Identification of the VP37 pocket of monkeypox virus as a promising target for pan-orthopoxvirus inhibitors through virtual screening and antiviral assays
期刊论文
OAI收割
EMERGING MICROBES & INFECTIONS, 2024, 卷号: 13, 期号: 1, 页码: 4
作者:
Huo, Shuting
;
Wu, Leyun
;
Huang, Baoying
;
Liu, Nan
;
Sun, Jiewei
  |  
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2024/08/22
An overview of the functions and mechanisms of APOBEC3A in tumorigenesis
期刊论文
OAI收割
ACTA PHARMACEUTICA SINICA B, 2024, 卷号: 14, 期号: 11, 页码: 4637-4648
作者:
Yang, Yuqi
;
Liu, Nan
;
Gong, Likun
  |  
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2025/01/06
Tumor-associated viruses
Tumor microenvironment
APOBEC3A
Deaminase
Mutation
DNA damage
Tumorigenesis
Tumor-associated viruses
Macrophage
Tumor microenvironment
Arctigenin induces activated HSCs quiescence via AMPK-PPARγ pathway to ameliorate liver fibrosis in mice
期刊论文
OAI收割
EUROPEAN JOURNAL OF PHARMACOLOGY, 2024, 卷号: 974, 页码: 10
作者:
Lv, Mengjia
;
Chen, Shiyi
;
Shan, Mengwen
;
Si, Yuan
;
Huang, Chenggang
  |  
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2024/07/12
Liver fibrosis
Arctigenin
Hepatic stellate cell (HSC)
AMPK
PPAR gamma
Novel Jatrophane Diterpenoids from
Euphorbia esula
Promotes Lipid Clearance by Transcriptional Regulation of PCSK9
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 67, 期号: 14, 页码: 12055-12067
作者:
Chen, Tong
;
Hou, Aijun
;
Guo, Pengju
;
Peng, Shou
;
Qin, Guoqing
  |  
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2024/08/22
Next-generation anti-PD-L1/IL-15 immunocytokine elicits superior antitumor immunity in cold tumors with minimal toxicity
期刊论文
OAI收割
CELL REPORTS MEDICINE, 2024, 卷号: 5, 期号: 5, 页码: 20
作者:
Shi, Wenqiang
;
Liu, Nan
;
Liu, Zexin
;
Yang, Yuqi
;
Zeng, Qiongya
  |  
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2024/09/26
Excessive fatty acids activate PRMT5/MDM2/Drosha pathway to regulate miRNA biogenesis and lipid metabolism
期刊论文
OAI收割
LIVER INTERNATIONAL, 2024, 页码: 17
作者:
Hou, Aijun
;
Xu, Xiaoding
;
Zhang, Yu
;
He, Hongxiu
;
Feng, Yihan
  |  
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2024/05/07
Drosha degradation
lipid metabolism
miRNA biogenesis
NAFLD
PRMT5
Eliminating drug target interference with specific antibody or its F(ab′)
2
fragment in the bridging immunogenicity assay
期刊论文
OAI收割
BIOANALYSIS, 2024, 页码: 14
作者:
Deng, Xiaojie
;
Hou, Yingying
;
Yuan, Wenyi
;
Yang, Hongzhou
;
Guo, Ruowen
  |  
收藏
  |  
浏览/下载:295/0
  |  
提交时间:2024/04/09
anti-drug antibody
IgE
immunogenicity
mitigation
target interference