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Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
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上海药物研究所 [46]
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Structure-Based Development of Ultra-Broad-Spectrum 3C-Like Protease Inhibitors
期刊论文
OAI收割
ADVANCED SCIENCE, 2025, 页码: 17
作者:
Su, Haixia
;
Nie, Tianqing
;
Chen, Guofeng
;
Xiong, Muya
;
Zhang, Yumin
  |  
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2026/01/29
3C-like protease
conservation analysis of the binding pocket
co-crystal structure
structure-based drug design
ultra-broad-spectrum inhibitors
Intensifying propagation from El Nino to regional drought in China
期刊论文
OAI收割
JOURNAL OF HYDROLOGY, 2025, 卷号: 662, 页码: 133999
作者:
Dong, Haixia
;
Huang, Shengzhi
;
Jin, Junliang
;
Shi, Haiyun
;
Gu, Xihui
  |  
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2025/09/22
Drought propagation
Conditional probability
Copula
Random forest
El Nino
Systematic analysis of Wnt family genes reveals the potential role of
Wnt4
in driving female differentiation in Spotted knifejaw
期刊论文
OAI收割
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2025, 卷号: 785, 页码: 11
作者:
Zhao, Haixia
;
Xiao, Yongshuang
;
Xiao, Zhizhong
;
Li, Jun
;
Xu, Shihong
  |  
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2025/12/09
Genome-wide
Wnt family
Spotted knifejaw
Female differentiation
wnt4
Identification of RIPK3 as a target of flavonoids for anti-necroptosis in vitro
期刊论文
OAI收割
BIOORGANIC CHEMISTRY, 2025, 卷号: 161, 页码: 11
作者:
Xie, Hang
;
Li, Wanchen
;
Han, Xiaoyu
;
Li, Minjun
;
Zhao, Qiang
  |  
收藏
  |  
浏览/下载:36/0
  |  
提交时间:2025/07/25
RIPK3
Inhibitors
Flavonoids
Co-crystal structure
Anti-necroptosis effect
Metabolomic and evolutionary integration unveils medicinal potential in six
Corydalis
species
期刊论文
OAI收割
MOLECULAR HORTICULTURE, 2025, 卷号: 5, 期号: 1, 页码: 14
作者:
Gao, Yun
;
Zhou, Xiangyu
;
Yan, Mengxiao
;
Wang, Zhengwei
;
Zhong, Xin
  |  
收藏
  |  
浏览/下载:35/0
  |  
提交时间:2025/08/20
Corydalis
genus
Benzylisoquinoline alkaloids (BIAs)
Evolutionary analysis
Metabolomics
Medicinal resources
Geochemical Characteristics and Origin of Heavy Metals and Dispersed Elements in Qarhan Salt Lake Brine
期刊论文
OAI收割
WATER, 2025, 卷号: 17, 期号: 13, 页码: 1927
作者:
Cai, Na
;
Wang, Wei
;
Xiao, Guotao
;
Yang, Zhiping
;
Zhu, Haixia
  |  
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2025/08/21
Qarhan Salt Lake
brine
heavy metals
dispersed elements
self-organizing map
positive matrix factorization
De novo design of protein condensation inhibitors by targeting an allosteric site of cGAS
期刊论文
OAI收割
NATURE COMMUNICATIONS, 2025, 卷号: 16, 期号: 1, 页码: 20
作者:
Zhao, Wenfeng
;
Chen, Guofeng
;
He, Jian
;
Shen, Xiaofang
;
Xiong, Muya
  |  
收藏
  |  
浏览/下载:33/0
  |  
提交时间:2025/08/20
Development of Orally Bioavailable Octahydroindole-Based Peptidomimetic Derivative as a Broad-Spectrum Inhibitor against HCoV-OC43 and SARS-CoV-2
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 68, 期号: 11, 页码: 10823-10844
作者:
Hu, Shulei
  |  
收藏
  |  
浏览/下载:45/0
  |  
提交时间:2025/07/25
Dynamic Cap-Mediated Substrate Access and Potent Inhibitor Design of Monkeypox Virus I7L Protease
期刊论文
OAI收割
ADVANCED SCIENCE, 2025, 页码: 13
作者:
Su, Haixia
;
Wu, Guoqing
  |  
收藏
  |  
浏览/下载:35/0
  |  
提交时间:2025/05/27
covalent inhibitors
I7L protease
monkeypox virus
protein structures
substrate proteolysis
Potency Prediction of Covalent Inhibitors against SARS-CoV-2 3CL-like Protease and Multiple Mutants by Multiscale Simulations
期刊论文
OAI收割
JOURNAL OF CHEMICAL INFORMATION AND MODELING, 2024, 卷号: 64, 期号: 24, 页码: 9501-9516
作者:
Xiong, Muya
;
Nie, Tianqing
;
Li, Zhewen
;
Hu, Meiyi
;
Su, Haixia
  |  
收藏
  |  
浏览/下载:34/0
  |  
提交时间:2025/01/06