机构

• 上海药物研究所 [17]
• 西安光学精密机械研究... [2]
• 计算技术研究所 [1]

采集方式

• OAI收割 [20]

内容类型

• 期刊论文 [18]
• 专利 [2]

发表日期

• 2023 [4]
• 2022 [1]
• 2021 [6]
• 2020 [4]
• 2019 [3]
• 2015 [2]
• 更多

学科主题

筛选

浏览/检索结果: 共20条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择题名升序题名降序提交时间升序提交时间降序作者升序作者降序发表日期升序发表日期降序 Structure-based drug discovery of novel fused- pyrazolone carboxamide derivatives as potent and selective AXL inhibitors 期刊论文  OAI收割 ACTA PHARMACEUTICA SINICA B, 2023, 卷号: 13, 期号: 12, 页码: 4918-4933 作者:  Fang, Feifei;  Dai, Yang;  Wang, Hao;  Ji, Yinchun;  Liang, Xuewu   |  收藏  |  浏览/下载：23/0  |  提交时间：2024/01/26 derivatives  Antitumor drug development  Potential AXL inhibitor  Antitumor activity  Structure-based drug design  Fused-pyrazolone carboxamide   Rapid Access to Polysubstituted Tetrahydrocarbazol-4-ones via Sequential Selective C-H Functionalization from N-Nitrosoanilines 期刊论文  OAI收割 CHINESE JOURNAL OF CHEMISTRY, 2023, 页码: 1957-1962 作者:  Li, Chan;  Yang, Yanchen;  Fang, Feifei;  Liu, Chaoyi;  Li, Chunpu   |  收藏  |  浏览/下载：27/0  |  提交时间：2023/10/17 C-H activation  Cross dehydrogenative coupling  Rhodium catalysis  Iridium catalysis  Alkenylation  Amaidiation  Heteroarylation   Rh(III)-Catalyzed Synthesis of Substituted Isoindoles through a Direct C-H Activation/[4+1] Annulation and Acyl Migration Cascade of Oxadiazolones with Diazo Compounds 期刊论文  OAI收割 ORGANIC LETTERS, 2023, 页码: 5 作者:  Yang, Xiaohao;  Ren, Hairu;  Zhou, Shengbin;  Li, Chunpu;  Liu, Chaoyi   |  收藏  |  浏览/下载：19/0  |  提交时间：2023/10/17 Structural Optimization of Fibroblast Growth Factor Receptor Inhibitors for Treating Solid Tumors 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 66, 期号: 5, 页码: 3226-3249 作者:  Li, Chunpu;  Dai, Yang;  Kong, Xiangtai;  Wang, Bao;  Peng, Xia   |  收藏  |  浏览/下载：16/0  |  提交时间：2024/03/27 Discovery of Pyrazolo[3,4-d]pyridazinone Derivatives as Selective DDR1 Inhibitors via Deep Learning Based Design, Synthesis, and Biological Evaluation 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 65, 期号: 1, 页码: 103-119 作者:  Tan, Xiaoqin;  Li, Chunpu;  Yang, Ruirui;  Zhao, Sen;  Li, Fei   |  收藏  |  浏览/下载：52/0  |  提交时间：2022/06/15 5-Aminonaphthalene derivatives as selective nonnucleoside nuclear receptor binding SET domain-protein 2 (NSD2) inhibitors for the treatment of multiple myeloma 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 222, 页码: 19 作者:  Wang, Shuni;  Yang, Hong;  Su, Mingbo;  Lian, Fulin;  Cong, Zhanqing   |  收藏  |  浏览/下载：74/0  |  提交时间：2021/11/04 NSD2  Methyltransferase  HTS  Multiple myeloma  5-Aminonaphthalene derivatives  Inhibitor   Identification of Novel Fused Heteroaromatics-Based MALT1 Inhibitors by High-Throughput Screening to Treat B Cell Lymphoma 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 13, 页码: 9217-9237 作者:  Liang, Xuewu;  Sun, Chenxia;  Li, Chunpu   |  收藏  |  浏览/下载：29/0  |  提交时间：2021/08/17 MALT1 as a promising target to treat lymphoma and other diseases related to MALT1 anomalies 期刊论文  OAI收割 MEDICINAL RESEARCH REVIEWS, 2021, 页码: 35 作者:  Liang, Xuewu;  Cao, YiChun;  Li, Chunpu;  Yu, Haolan;  Yang, Chenghua   |  收藏  |  浏览/下载：34/0  |  提交时间：2021/05/24 DLBCL  MALT lymphoma  MALT1  MALT1 inhibitors  NF‐  κ  B pathway   Discovery of 5-Benzylidene-2-phenyl-1,3-dioxane-4,6-diones as Highly Potent and Selective SIRT1 Inhibitors 期刊论文  OAI收割 ACS MEDICINAL CHEMISTRY LETTERS, 2021, 卷号: 12, 期号: 3, 页码: 397-403 作者:  Li, Chunpu;  Hu, Sha-Sha;  Yang, Lisheng;  Wang, Min;  Long, Jian-Dong   |  收藏  |  浏览/下载：75/0  |  提交时间：2021/05/24 SIRT1  inhibitor  structure-activity relationship  interaction  deacetylase   Design, synthesis and biological evaluation of pyrazolo[3,4-d]pyridazinone derivatives as covalent FGFR inhibitors 期刊论文  OAI收割 ACTA PHARMACEUTICA SINICA B, 2021, 卷号: 11, 期号: 3, 页码: 781-794 作者:  Wu, Xiaowei;  Dai, Mengdi;  Cui, Rongrong;  Wang, Yulan;  Li, Chunpu   |  收藏  |  浏览/下载：53/0  |  提交时间：2021/05/24 Tyrosine kinase  Covalent FGFR inhibitors  Virtual screening  Pyrazolo[3,4-d] pyridazinone  Structure-activity relationships  Antitumor efficacy