中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
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上海药物研究所 [339]
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Discovery of pyrrolo[2,3-d]pyrimidine derivatives as novel FLT3/ IRAK4 inhibitors
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 296, 页码: 23
作者:
Yuan, Haibin
;
Gao, Yue
;
Wang, Peipei
;
Dong, Xiaowu
;
Li, Jia
  |  
收藏
  |  
浏览/下载:1/0
  |  
提交时间:2025/08/20
AML
FLT3/IRAK4 inhibitor
Pyrrolo [2,3-d] pyrimidine
Acquired resistance
Adaptive resistance
Design, synthesis, and evaluation of Menin-targeting compounds for the treatment of acute Myelocytic leukemia (AML)
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 296, 页码: 17
作者:
Mo, Jun
;
Wang, Yuxian
;
Pan, Youlu
;
Xiao, Qitao
;
Zhao, Jinyi
  |  
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2025/08/20
Menin
High binding affinity
Anti-proliferation activity
AML
Human gut
Bifidobacterium longum
subsp.
suillum
is enriched in vitro by a pectic polysaccharide isolated from the flowers of
Lilium lancifolium
期刊论文
OAI收割
CARBOHYDRATE POLYMERS, 2025, 卷号: 364, 页码: 14
作者:
Li, Meixia
;
Liu, Renjie
;
Wang, Tao
;
Duo, Lana
;
Chen, Guo
  |  
收藏
  |  
浏览/下载:1/0
  |  
提交时间:2025/08/20
Polysaccharides
Lilium lancifolium
Human gut microbiota
Bifidobacterium longum subsp. suillum
Discovery of potent anti-idiopathic pulmonary fibrosis (IPF) agents based on an o-aminopyridinyl alkynyl scaffold
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 294, 页码: 15
作者:
Wang, Yang
;
Fan, Wenhui
;
Guo, Yihao
;
Sun, Li
;
Hu, Youhong
  |  
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2025/08/20
IPF
EMT
Key kinases
Inhibitors
Discovery of novel imidazo[2,1-b][1,3,4]thiadiazole analogs as fluorescent SHP2 inhibitors
期刊论文
OAI收割
BIOORGANIC CHEMISTRY, 2025, 卷号: 163, 页码: 10
作者:
Zhang, Chun
;
Yan, Xue
;
Gao, Li-Xin
;
Cao, Zi-Tong
;
Cao, Qing
  |  
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2025/08/20
Imidazo[2,1-b][1,3,4]thiadiazole
Inhibitory activities
Fluorescence imaging
Zebrafish
SHP2
Guiding precision medicine strategy for intravenous ginsenosides via pharmacokinetic-informed bioinformatic approaches: a study on XueShuanTong
期刊论文
OAI收割
PHYTOMEDICINE, 2025, 卷号: 143, 页码: 18
作者:
Jia, Wei-Wei
;
Tian, Nan-Nan
;
Song, Zi-Jing
;
Lan, Xiao-Fang
;
Yang, Xi-He
  |  
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2025/08/20
Precision medicine
Physiologically based pharmacokinetic model
Ginsenoside
Albumin-facilitated dissociation
Drug interaction
Drug transporter
Hepatic impairment
Integrative Proteomics and Histone PTMomics Study on Anti-TNBC Effect of JIB-04
期刊论文
OAI收割
JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, 2025, 页码: 12
作者:
Tao, Shengna
;
Guo, Jingli
;
Zhang, Jingdan
;
Zhang, Mingya
;
Wang, Zhe
  |  
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2025/08/20
Proteomics
histone PTMomics
epigenetic inhibitor
JIB-04
TNBC
Covalent sortase A inhibitor, α, β-unsaturated aldehydes, prevents Staphylococcus aureus infection
期刊论文
OAI收割
MICROBIAL PATHOGENESIS, 2025, 卷号: 204, 页码: 12
作者:
Wang, Jianchao
;
He, Yuan
;
Chu, Chenliang
;
Wu, Ziqi
;
Zhang, Ting
  |  
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2025/06/23
Sortase A
Covalent inhibitor
alpha
beta-unsaturated aldehydes
Anti-virulence therapy
Staphylococcus aureus
Nanohydroxyapatite-Stabilized Pickering-Emulsion-Incorporated Hydrogel Prevents Postoperative Osteosarcoma Recurrence and Promotes Bone Repair
期刊论文
OAI收割
NANO LETTERS, 2025, 卷号: 25, 期号: 26, 页码: 10487-10496
作者:
Zhang, Yi
;
Wang, Yuewei
;
Zhang, Xiaofei
;
Yue, Lixia
;
Yang, Lu
  |  
收藏
  |  
浏览/下载:1/0
  |  
提交时间:2025/08/20
osteosarcoma
injectable hydrogel
nanohydroxyapatite
Pickering emulsion
RANKL inhibitor
bone regeneration
Rapid Discovery of Celastrol Derivatives as Potent and Selective PRDX1 Inhibitors via Microplate-Based Parallel Compound Library and In Situ Screening
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 68, 期号: 13, 页码: 13609-13627
作者:
Chen, Shuang
;
Wang, Zhenyu
;
Gao, Jia
;
Wang, Yanlin
;
Liang, Jiayin
  |  
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2025/08/20