中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
机构
上海药物研究所 [35]
化学研究所 [17]
上海营养与健康研究所 [4]
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OAI收割 [60]
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期刊论文 [59]
专利 [1]
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2025 [3]
2024 [2]
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2022 [8]
2021 [5]
2020 [9]
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Cell Biolo... [3]
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Development and validation of an LC-MS/MS method with precolumn derivatization for the determination of dimethoxyethyl phthalate metabolites ethylene glycol methyl ether and methoxyacetic acid in rat plasma
期刊论文
OAI收割
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2025, 卷号: 261, 页码: 8
作者:
Cui, Xinran
;
Wang, Yongbin
;
Zhan, Yan
;
Chen, Xiaoyan
  |  
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2025/05/27
LC-MS/MS
Derivatization
Ethylene glycol methyl ether
Methoxyacetic acid
Dimethoxyethyl phthalate
Synthesis and biological evaluation of amino-conjugated bile acid derivatives against non-alcoholic steatohepatitis
期刊论文
OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2025, 卷号: 122, 页码: 6
作者:
Wu, Zhitao
;
Zhang, Mingge
;
Yan, Meng Kun
;
Li, Chenyue
;
Pan, Guoyu
  |  
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2025/05/27
Non-alcoholic steatohepatitis (NASH)
Bile acid derivatives
Anti-lipid accumulation activities
Anti-inflammatory activities
Anti-fibrosis activities
Discovery of peptidomimetic spiropyrrolidine derivatives as novel 3CLpro inhibitors against SARS-CoV-2
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 281, 页码: 22
作者:
Guma, Samuel Desta
;
Zhou, Zhaoyin
;
Song, Kang
;
Yang, Feipu
;
Suo, Jin
  |  
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2024/12/11
SARS-CoV-2
3CL pro inhibitors
Peptidomimetics
Spiropyrrolidine derivatives
Mobilizing STING Pathway via a Cationic Liposome to Enhance Doxorubicin-Induced Antitumor Immunity
期刊论文
OAI收割
ADVANCED FUNCTIONAL MATERIALS, 2024, 页码: 12
作者:
Liu, Xiaochen
;
Zhao, Zhiwen
;
Xu, Xiaoxuan
;
Yi, Wenzhe
;
Yan, Dan
  |  
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2024/11/26
biological barriers
cancer immunotherapy
cationic liposomes
immunogenic cell death
STING pathway
Simultaneous determination of BGT-002 and its acyl glucuronide metabolite ZM326E-M2 in human plasma by liquid chromatography-tandem mass spectrometry and its application to a pharmacokinetic study
期刊论文
OAI收割
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2024, 卷号: 243, 页码: 8
作者:
Zhu, Xueran
;
Cui, Shumin
;
Liu, Xinjing
;
Zhang, Mei
;
Xie, Zhifu
  |  
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2024/05/31
ATP-Citrate Lyase
BGT-002
Acyl glucuronide metabolite
Pseudo-MRM
LC-MS/MS
Pharmacokinetics
Co-delivering irinotecan and imiquimod by pH-responsive micelle amplifies anti-tumor immunity against colorectal cancer
期刊论文
OAI收割
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2023, 卷号: 648, 页码: 14
作者:
Yan, Wenlu
;
Li, Yu
;
Zou, Yiting
;
Zhu, Runqi
;
Wu, Ting
  |  
收藏
  |  
浏览/下载:68/0
  |  
提交时间:2024/01/16
Colorectal cancer
Irinotecan
Imiquimod
Micelle
Immune response
Identification of [1,2,4]Triazolo[4,3-a]pyrazine PARP1 inhibitors with overcome acquired resistance activities
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 259, 页码: 19
作者:
Wang, Pingyuan
;
Zhu, Wen-Ting
;
Wang, Yajing
;
Song, Shan-Shan
;
Xi, Yong
  |  
收藏
  |  
浏览/下载:75/0
  |  
提交时间:2023/10/17
PARP1 inhibitor
Synthetic lethality
Drug resistance
Anticancer
Structure -activity relationship
Multiple heart-cutting two-dimensional liquid chromatography/charged aerosol detector assay of ginsenosides for quality evaluation of ginseng from diverse Chinese patent medicines
期刊论文
OAI收割
JOURNAL OF CHROMATOGRAPHY A, 2023, 卷号: 1708, 页码: 10
作者:
Xu, Xiao-yan
;
Jiang, Mei-ting
;
Wang, Yu
;
Sun, He
;
Jing, Qi
  |  
收藏
  |  
浏览/下载:36/0
  |  
提交时间:2023/12/08
Multiple heart -cutting two-dimensional liquid
chromatography
Charged aerosol detector
Quantitative assay
Ginseng
Chinese patent medicine
Identification of XAF1 as an endogenous AKT inhibitor
期刊论文
OAI收割
CELL REPORTS, 2023, 卷号: 42, 期号: 7, 页码: 25
作者:
Chen, Min
;
Wang, Kangjunjie
;
Han, Ying
;
Yan, Shukun
;
Yuan, Huairui
  |  
收藏
  |  
浏览/下载:39/0
  |  
提交时间:2023/10/17
Discovery of selective NaV1.8 inhibitors based on 5-chloro-2-(4,4-difluor- oazepan-1-yl)-6-methyl nicotinamide scaffold for the treatment of pain
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 254, 页码: 12
作者:
Qin, Hui
;
Wei, Aihuan
;
Wang, Yunqi
;
Wang, Linlin
;
Xu, Haiyan
  |  
收藏
  |  
浏览/下载:32/0
  |  
提交时间:2023/10/17
Pain
Non-addictive analgesics
Na V 1
8-selective inhibitors
Bicyclic aromatic groups