中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
机构
上海药物研究所 [10]
过程工程研究所 [3]
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期刊论文 [27]
会议论文 [1]
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2025 [2]
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浏览/检索结果:
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PEGylation of Dipeptide Linker Improves Therapeutic Index and Pharmacokinetics of Antibody-Drug Conjugates
期刊论文
OAI收割
BIOCONJUGATE CHEMISTRY, 2025, 页码: 11
作者:
Long, Jing
;
Shao, Ting
;
Wang, Yongmei
;
Chen, Tianzhi
;
Chen, Yuning
  |  
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2025/04/01
Simultaneous Quantification of Total Antibody and Conjugated Payload for DS001 in Rat Serum Using a Hybrid Immuno-Capture LC-MS/MS
期刊论文
OAI收割
AAPS JOURNAL, 2025, 卷号: 27, 期号: 1, 页码: 13
作者:
Yu, Xiong
;
Li, Weiqiang
;
Huang, Wensi
;
Xiao, Bo
;
Long, Jing
  |  
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2025/04/01
ADC
LC-MS/MS
payload
simultaneous quantification
total antibody
Discovery of a Potent, selective and orally bioavailable CDK9 degrader for targeting transcription regulation in Triple-Negative breast cancer
期刊论文
OAI收割
BIOORGANIC CHEMISTRY, 2024, 卷号: 153, 页码: 16
作者:
Nie, Hui-Jun
;
Li, Ben-Fu
;
Sun, Jingya
;
Yuan, Yali
;
Zhang, Zhi-Gao
  |  
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2024/11/26
Triple-negative breast cancer
Targeting transcription regulation
Orally bioavailable degrader
PROTAC
Cyclin-dependent Kinase 9
Discovery of Orally Bioavailable and Potent CDK9 Inhibitors for Targeting Transcription Regulation in Triple-Negative Breast Cancer
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 67, 期号: 12, 页码: 10035-10056
作者:
Wang, Wen-Jing
;
Gao, Lixin
;
Wang, Simei
;
Huang, Wensi
;
Meng, Xin-Yu
  |  
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2024/08/20
Cross-ancestry genome-wide association studies of brain imaging phenotypes
期刊论文
OAI收割
NATURE GENETICS, 2024, 页码: 31
作者:
Fu, Jilian
;
Zhang, Quan
;
Wang, Jianhua
;
Wang, Meiyun
;
Zhang, Bing
  |  
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2024/06/29
Metabolism investigation of the peptide-drug conjugate LN005 in rats using UHPLC-HRMS
期刊论文
OAI收割
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2024, 卷号: 238, 页码: 11
作者:
Wang, Weiqiang
;
Chen, Chong
;
Luo, Jing
;
Tang, Chongzhuang
;
Zheng, Yuandong
  |  
收藏
  |  
浏览/下载:37/0
  |  
提交时间:2024/01/16
LN005
Metabolism
Peptide -drug conjugates
UHPLC-HRMS
Doxorubicin
Metabolite characterisation of the peptide-drug conjugate LN005 in liver S9s by UHPLC-Orbitrap-HRMS
期刊论文
OAI收割
XENOBIOTICA, 2024, 页码: 9
作者:
Yuan, Yali
;
Wang, Weiqiang
;
Luo, Jing
;
Tang, Chongzhuang
;
Zheng, Yuandong
  |  
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2024/02/19
peptide-drug conjugate
PDC
LN005
metabolite identification
liver S9s
A potent PGK1 antagonist reveals PGK1 regulates the production of IL-1 beta and IL-6
期刊论文
OAI收割
ACTA PHARMACEUTICA SINICA B, 2022, 卷号: 12, 期号: 11, 页码: 4180-4192
作者:
Liao, Liping
;
Dang, Wenzhen
;
Lin, Tingting
;
Yu, Jinghua
;
Liu, Tonghai
  |  
收藏
  |  
浏览/下载:31/0
  |  
提交时间:2023/04/10
Glycolysis
Phosphoglycerate kinase 1
Macrophages
NRF2
Inflammation
Pharmacokinetics, mass balance, and metabolism of [C-14]TPN171, a novel PDE5 inhibitor, in humans for the treatment of pulmonary arterial hypertension
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2022, 页码: 13
作者:
He, Yi-fei
;
Liu, Yin
;
Yu, Jing-hua
;
Cheng, Huan
;
Odilov, Abdullajon
  |  
收藏
  |  
浏览/下载:42/0
  |  
提交时间:2022/08/16
TPN171
[C-14]TPN171
PDE5 inhibitor
pulmonary arterial hypertension
healthy volunteers
pharmacokinetics
metabolite identification
mass balance
Two Novel Rare Earth Coordination Polymers Derived from Zwitterionic 1,3-Bis(1-carboxylatoethyl)imidazolium Bromide: Structures and Magnetic Properties
期刊论文
OAI收割
JOURNAL OF MOLECULAR STRUCTURE, 2022, 卷号: 1250, 页码: 8
作者:
Liu, Mengchen
;
Yin, Qianqian
;
Zhong, Shengnan
;
Sun, Huimin
;
Wang, Yibo
  |  
收藏
  |  
浏览/下载:46/0
  |  
提交时间:2022/06/15
Rare earth
Coordination polymer
Zwitterionic ligand
X-ray diffraction
Magnetic Property