机构

• 上海药物研究所 [108]
• 化学研究所 [1]

采集方式

• OAI收割 [109]

内容类型

• 期刊论文 [106]
• 会议论文 [3]

发表日期

• 2026 [2]
• 2025 [9]
• 2024 [4]
• 2023 [4]
• 2022 [6]
• 2021 [5]
• 更多

学科主题

筛选

浏览/检索结果: 共109条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择发表日期升序发表日期降序题名升序题名降序提交时间升序提交时间降序作者升序作者降序 DMetFinder: A novel mass spectrometry analysis tool for comprehensive drug metabolite detection 期刊论文  OAI收割 TALANTA, 2026, 卷号: 298, 页码: 9 作者:  Ke, Wenhao;  Wang, Yingying;  Zeng, Yanping;  Hou, Haiyang;  Zhu, Dafu   |  收藏  |  浏览/下载：0/0  |  提交时间：2025/12/04 DMetFinder  Drug metabolites  LC-MS/MS  Spectrum similarity  Mass defect filter  Isotope pattern   Multiplexed Isotope-Coded Mass Spectrometry Footprinting Enables Broad Heteroatom-Residue Mapping and Uncovers Noncanonical Ligand-Binding Sites in Amyloidosis Proteins 期刊论文  OAI收割 ANALYTICAL CHEMISTRY, 2026, 页码: 13 作者:  Yang, Kuoqi;  Zheng, Wei;  Bai, Lin;  Wang, Kai;  Zhang, Jian   |  收藏  |  浏览/下载：0/0  |  提交时间：2026/04/01 Design, synthesis, and biological evaluation of KDM5B degraders against hematologic malignancy cells 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 296, 页码: 17 作者:  Liu, Xiaowen;  Li, Jiarong;  Guo, Yihao;  Xie, Zhicheng;  Geng, Meiyu   |  收藏  |  浏览/下载：0/0  |  提交时间：2025/12/04 KDM5B  PROTAC  TPD  Hematological malignancy   Structural optimization of phthalazine derivatives for anti-HBV activities to improve oral bioavailability 期刊论文  OAI收割 BIOORGANIC & MEDICINAL CHEMISTRY, 2025, 卷号: 128, 页码: 10 作者:  Yang, Yurong;  Xiao, Fuling;  Zuo, Jianping;  Yang, Li;  Hu, Youhong   |  收藏  |  浏览/下载：73/0  |  提交时间：2025/08/20 HBV  Capsid assembly modulators  Structural optimization  Oxidative metabolism   Design and synthesis of CDK9/EZH2 dual-target inhibitors to achieve synergistic antitumor effects 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 294, 页码: 14 作者:  Tian, Lina;  Xiao, Jian;  Zeng, Yanping;  Li, Yangsha;  Wei, Aihuan   |  收藏  |  浏览/下载：73/0  |  提交时间：2025/08/20 CDK9  EZH2  Dual target inhibitor  DLBCL   Discovery of potent anti-idiopathic pulmonary fibrosis (IPF) agents based on an o-aminopyridinyl alkynyl scaffold 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 294, 页码: 15 作者:  Wang, Yang;  Fan, Wenhui;  Guo, Yihao;  Sun, Li;  Hu, Youhong   |  收藏  |  浏览/下载：37/0  |  提交时间：2025/08/20 IPF  EMT  Key kinases  Inhibitors   Discovery of novel Ebola entry inhibitors with 1,2,3,4-tetrahydroisoquinoline-3-carboxamide based on (3S,4aS,8aS)-2-(3-amino-2-hydroxypropyl) decahydroisoquinoline-3-carboxamide scaffold 期刊论文  OAI收割 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2025, 卷号: 123, 页码: 4 作者:  Lin, Junzhen;  Xiao, Fuling;  Han, Sheng;  Hu, Youhong;  Zuo, Jianping   |  收藏  |  浏览/下载：38/0  |  提交时间：2025/06/23 Ebola virus entry inhibitor  Tetrahydroisoquinoline   Fine structural design of 3βHSD1 inhibitors for prostate cancer 期刊论文  OAI收割 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2025, 卷号: 122, 期号: 26, 页码: 12 作者:  He, Dongyin;  Zhang, Luyao;  Yu, Leiye;  Zhang, Yuhang;  Chen, Jingjing   |  收藏  |  浏览/下载：0/0  |  提交时间：2025/09/09 prostate cancer  drug development  AlphaFold  molecular simulations  3 beta 3HSD1   Discovery of 2,4-quinazolinedione derivatives as LC3B recruiters in the facilitation of protein complex degradations 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 287, 页码: 10 作者:  Zeng, Yanping;  Xiao, Jian;  Shi, Li;  Li, Yangsha;  Xu, Yuanxin   |  收藏  |  浏览/下载：115/0  |  提交时间：2025/04/01 LC3B  CDK9  Degradation  Protein complex   Diazonium-based derivatization for enhanced detection of phosphorylated metabolites by LC-MS in cells 期刊论文  OAI收割 JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2025, 卷号: 255, 页码: 7 作者:  Wang, Yikang;  Lin, Feifei;  Zhu, Guozheng;  Zhou, Xiaoxue;  Hu, Youhong   |  收藏  |  浏览/下载：52/0  |  提交时间：2025/04/01 Phosphorylated metabolite  Derivatization  Chromatographic separation  Quantitative analysis  LC-MS