中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
机构
上海药物研究所 [104]
化学研究所 [1]
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OAI收割 [105]
内容类型
期刊论文 [102]
会议论文 [3]
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2025 [7]
2024 [4]
2023 [4]
2022 [6]
2021 [5]
2020 [3]
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Structural optimization of phthalazine derivatives for anti-HBV activities to improve oral bioavailability
期刊论文
OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY, 2025, 卷号: 128, 页码: 10
作者:
Yang, Yurong
;
Xiao, Fuling
;
Zuo, Jianping
;
Yang, Li
;
Hu, Youhong
  |  
收藏
  |  
浏览/下载:1/0
  |  
提交时间:2025/08/20
HBV
Capsid assembly modulators
Structural optimization
Oxidative metabolism
Design and synthesis of CDK9/EZH2 dual-target inhibitors to achieve synergistic antitumor effects
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 294, 页码: 14
作者:
Tian, Lina
;
Xiao, Jian
;
Zeng, Yanping
;
Li, Yangsha
;
Wei, Aihuan
  |  
收藏
  |  
浏览/下载:1/0
  |  
提交时间:2025/08/20
CDK9
EZH2
Dual target inhibitor
DLBCL
Discovery of potent anti-idiopathic pulmonary fibrosis (IPF) agents based on an o-aminopyridinyl alkynyl scaffold
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 294, 页码: 15
作者:
Wang, Yang
;
Fan, Wenhui
;
Guo, Yihao
;
Sun, Li
;
Hu, Youhong
  |  
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2025/08/20
IPF
EMT
Key kinases
Inhibitors
Discovery of novel Ebola entry inhibitors with 1,2,3,4-tetrahydroisoquinoline-3-carboxamide based on (3S,4aS,8aS)-2-(3-amino-2-hydroxypropyl) decahydroisoquinoline-3-carboxamide scaffold
期刊论文
OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2025, 卷号: 123, 页码: 4
作者:
Lin, Junzhen
;
Xiao, Fuling
;
Han, Sheng
;
Hu, Youhong
;
Zuo, Jianping
  |  
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2025/06/23
Ebola virus entry inhibitor
Tetrahydroisoquinoline
Discovery of 2,4-quinazolinedione derivatives as LC3B recruiters in the facilitation of protein complex degradations
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 287, 页码: 10
作者:
  |  
收藏
  |  
浏览/下载:75/0
  |  
提交时间:2025/04/01
LC3B
CDK9
Degradation
Protein complex
Diazonium-based derivatization for enhanced detection of phosphorylated metabolites by LC-MS in cells
期刊论文
OAI收割
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2025, 卷号: 255, 页码: 7
作者:
Wang, Yikang
;
Lin, Feifei
;
Zhu, Guozheng
;
Zhou, Xiaoxue
;
Hu, Youhong
  |  
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2025/04/01
Phosphorylated metabolite
Derivatization
Chromatographic separation
Quantitative analysis
LC-MS
Discovery of novel biaryl urea derivatives against IL-1/3 release with low toxicity based on NEK7 inhibitor
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 283, 页码: 12
作者:
Wang, Leibo
;
Zhu, Kehan
;
Tian, Ziyang
;
Wang, Haoyu
;
Jia, Yulei
  |  
收藏
  |  
浏览/下载:33/0
  |  
提交时间:2025/01/14
NLRP3 inflammasome
NEK7
NLRP3-NEK7
Inhibitors
C(sp
3
)-H Carbonylative Cyclization of Hydrazones with CO
2
: Synthesis of Pyrazolone Derivatives
期刊论文
OAI收割
JOURNAL OF ORGANIC CHEMISTRY, 2024, 卷号: 89, 期号: 24, 页码: 18746-18751
作者:
Wang, Kai
;
Ouyang, Jun
  |  
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2025/01/14
Structural Optimization of Isoquinoline Derivatives from Lycobetaine and Their Inhibitory Activity against Neuroendocrine Prostate Cancer Cells
期刊论文
OAI收割
MOLECULES, 2024, 卷号: 29, 期号: 18, 页码: 28
作者:
Zhang, Zhuo
;
Shen, Qianqian
;
Ji, Yiyi
;
Ma, Yanjie
;
Hou, Haiyang
  |  
收藏
  |  
浏览/下载:32/0
  |  
提交时间:2024/11/05
NEPC
natural product
natural product derivatives
lycobetaine
A novel BODIPY-based theranostic agent for
in vivo
fluorescence imaging of cerebral Aβ and ameliorating Aβ-associated disorders in Alzheimer's disease transgenic mice
期刊论文
OAI收割
RSC MEDICINAL CHEMISTRY, 2024, 页码: 9
作者:
Zhang, Jingjing
;
Ren, Wenming
;
Liu, Xiaohui
;
Chen, Jingjing
;
Zeng, Yuteng
  |  
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2024/05/07