中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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上海药物研究所 [102]
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Design, synthesis, and evaluation of Menin-targeting compounds for the treatment of acute Myelocytic leukemia (AML)
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 296, 页码: 17
作者:
Mo, Jun
;
Wang, Yuxian
;
Pan, Youlu
;
Xiao, Qitao
;
Zhao, Jinyi
  |  
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2025/08/20
Menin
High binding affinity
Anti-proliferation activity
AML
Arabinogalactan-like polysaccharide isolated from the flowers of
Dendrobium
officinale
regulates the gut microbes and promotes vitamin K1, vitamin A, and vitamin B6 products
期刊论文
OAI收割
CARBOHYDRATE POLYMERS, 2025, 卷号: 366, 页码: 13
作者:
Jin, Can
;
Li, Meixia
;
Duo, Lana
;
Chen, Huixian
;
Guo, Xiaozhen
  |  
收藏
  |  
浏览/下载:1/0
  |  
提交时间:2025/08/20
Dendrobium officinale
Polysaccharide
Arabinogalactan
Bacteroides spp.
Vitamin
Human gut
Bifidobacterium longum
subsp.
suillum
is enriched in vitro by a pectic polysaccharide isolated from the flowers of
Lilium lancifolium
期刊论文
OAI收割
CARBOHYDRATE POLYMERS, 2025, 卷号: 364, 页码: 14
作者:
Li, Meixia
;
Liu, Renjie
;
Wang, Tao
;
Duo, Lana
;
Chen, Guo
  |  
收藏
  |  
浏览/下载:1/0
  |  
提交时间:2025/08/20
Polysaccharides
Lilium lancifolium
Human gut microbiota
Bifidobacterium longum subsp. suillum
A polysaccharide from
Gynostemma
pentaphyllum:
structure characterization and anti-insulin resistance potential through Galectin-3 modulation
期刊论文
OAI收割
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2025, 卷号: 310, 页码: 8
作者:
Ren, Mingwang
;
Sun, Guoqing
;
Ding, Xiaoyu
;
Yu, Xiaolin
;
He, Li
  |  
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2025/07/25
Gynostemma pentaphyllum
Polysaccharides
Structural characterization
Insulin resistance
Galectin-3
An adaptive OD flow clustering method to identify heterogeneous urban mobility trends
期刊论文
OAI收割
JOURNAL OF TRANSPORT GEOGRAPHY, 2025, 卷号: 123, 页码: 14
作者:
Guo, Xiaogang
;
Fang, Mengyuan
;
Tang, Luliang
  |  
收藏
  |  
浏览/下载:30/0
  |  
提交时间:2025/03/03
OD flow clustering
OPTICS
Spatial statistics
Density heterogeneity
Urban mobility
Exploratory research on the effective chemical basis of tanreqing injection for treating acute lung injury: In vivo, in vitro and in silico
期刊论文
OAI收割
JOURNAL OF ETHNOPHARMACOLOGY, 2025, 卷号: 337, 页码: 11
作者:
Tang, Bixi
;
Xie, Like
;
Wang, Yangyang
;
Shi, Yulong
;
Kan, Weijuan
  |  
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2024/11/26
Lung first-pass effect
Tanreqing injection
Pharmacokinetics
Sepsis-associated acute lung injury
Acute respiratory distress syndrome
Peptidoglycan isolated from the fruit of
Lycium barbarum
alleviates liver fibrosis in mice by regulating the TGF-β/Smad7 signaling and gut microbiota
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2025, 页码: 16
作者:
Nie, Ying-min
;
Zhou, Wan-qi
;
Niu, Ting
;
Mao, Meng-fei
;
Zhan, Yu-xue
  |  
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2025/04/01
liver fibrosis
Lycium barbarum
peptidoglycan
LBPW
TGF-beta/Smad7
Akkermansia muciniphila
A novel pectin-like polysaccharide from Crocus sativus targets Galectin-3 to inhibit hepatic stellate cells activation and liver fibrosis
期刊论文
OAI收割
CARBOHYDRATE POLYMERS, 2025, 卷号: 348, 页码: 16
作者:
Tang, Bixi
;
Jin, Can
;
Li, Maoting
;
Liu, Siqi
;
Zhang, Xuemei
  |  
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2024/12/11
Liver fibrosis
Galectin 3
Pectin
Polysaccharide structure
Hepatic stellate cell
The structure elucidation and alleviating effect on liver fibrosis in vivo of pectin-like polysaccharide isolated from
Buddleja
officinalis
期刊论文
OAI收割
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2025, 卷号: 284, 页码: 14
作者:
Zong, Jianing
;
Li, Yun
;
Zhou, Wanqi
;
Mao, Mengfei
;
Xu, Xin
  |  
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2025/01/14
Buddleja officinalis
Polysaccharides
Pectin
Liver fibrosis
Design and development of a series of 4-(piperazin-1-yl)pyrimidines as irreversible menin inhibitors
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 280, 页码: 20
作者:
Luo, Menglan
;
Ye, Yunfei
;
Tang, Lu
;
Kan, Weijuan
;
Chen, Lin
  |  
收藏
  |  
浏览/下载:33/0
  |  
提交时间:2024/11/26
Menin
Covalent inhibitor
Antitumor
Degradation