中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
机构
海洋研究所 [12]
金属研究所 [2]
上海药物研究所 [2]
采集方式
OAI收割 [16]
内容类型
期刊论文 [16]
发表日期
2022 [2]
2021 [1]
2020 [2]
2019 [2]
2017 [3]
2014 [1]
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学科主题
Pharmacolo... [2]
Chemistry,... [1]
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共16条,第1-10条
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Recent progress in fragment-based drug discovery facilitated by NMR spectroscopy
期刊论文
OAI收割
Magnetic Resonance Letters, 2022, 卷号: 2, 期号: 2, 页码: 107-118
作者:
Wang, Lei
;
Gao, Jia
;
Ma, Rongsheng
;
Liu, Yaqian
;
Liu, Mingqing
  |  
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2024/03/14
Fragment-based lead/drug discovery
NMR spectroscopy
Protein-ligand interaction
Complex structure
Hit-to-lead evolution
A novel dibenzo[a,c]phenazine-based fluorescent probe for fast and selective detection of thiophenols in environmental water
期刊论文
OAI收割
RSC ADVANCES, 2022, 卷号: 12, 期号: 14, 页码: 8611-8616
作者:
Guo, Shuju
;
Wang, Lijun
;
Jiang, Bo
  |  
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2022/07/15
Discovery of 5-(3-bromo-2-(2,3-dibromo-4,5-dimethoxybenzyl)-4,5-dimethoxybenzylidene)thiazolidine-2,4-dione as a novel potent protein tyrosine phosphatase 1B inhibitor with antidiabetic properties
期刊论文
OAI收割
BIOORGANIC CHEMISTRY, 2021, 卷号: 108, 页码: 13
作者:
Jiang, Bo
;
Luo, Jiao
;
Guo, Shuju
;
Wang, Lijun
  |  
收藏
  |  
浏览/下载:37/0
  |  
提交时间:2021/05/11
Type 2 diabetes mellitus
Protein tyrosine phosphatase 1B inhibitors
Thiazolidinedione
Insulin signaling
Anti-diabetic activities
Binding properties of marine bromophenols with human protein tyrosine phosphatase 1B: Molecular docking, surface plasmon resonance and cellular insulin resistance study
期刊论文
OAI收割
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2020, 卷号: 163, 页码: 200-208
作者:
Luo, Jiao
;
Zhang, Renshuai
;
Wang, Xuehe
;
Hou, Zhanhui
;
Guo, Shuju
  |  
收藏
  |  
浏览/下载:37/0
  |  
提交时间:2021/04/12
PTP1B
Bromophenol
Molecular docking
Surface plasmon resonance
Effects of a natural PTP1B inhibitor from Rhodomela confervoides on the amelioration of fatty acid-induced insulin resistance in hepatocytes and hyperglycaemia in STZ-induced diabetic rats
期刊论文
OAI收割
RSC ADVANCES, 2020, 卷号: 10, 期号: 6, 页码: 3429-3437
作者:
Guo, Shuju
;
Wang, Lijun
;
Chen, Dong
;
Jiang, Bo
  |  
收藏
  |  
浏览/下载:47/0
  |  
提交时间:2020/03/20
Chalcone-analogue fluorescent probes for detecting thiophenols in seawater samples
期刊论文
OAI收割
TALANTA, 2019, 卷号: 201, 页码: 301-308
作者:
Liu, Hua
;
Guo, Chuanlong
;
Guo, Shuju
;
Fan, Junting
;
Wang, Lijun
  |  
收藏
  |  
浏览/下载:89/0
  |  
提交时间:2019/08/29
Fluorescent probe
Thiophenol
Seawater sample
Chalcone
Design and Synthesis of a Fluorescent Probe with a Large Stokes Shift for Detecting Thiophenols and Its Application in Water Samples and Living Cells
期刊论文
OAI收割
MOLECULES, 2019, 卷号: 24, 期号: 2, 页码: 14
作者:
Liu, Hua
;
Guo, Chuanlong
;
Guo, Shuju
;
Wang, Lijun
;
Shi, Dayong
  |  
收藏
  |  
浏览/下载:60/0
  |  
提交时间:2019/08/27
fluorescent probe
thiophenol
water samples
chalcone
living cells
A novel fluorinated thiosemicarbazone derivative-2-(3,4-difluorobenzylidene) hydrazinecarbothioamide induces apoptosis in human A549 lung cancer cells via ROS-mediated mitochondria-dependent pathway
期刊论文
OAI收割
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2017, 卷号: 491, 期号: 1, 页码: 65-71
作者:
Zhao, Yue
;
Guo, Chuanlong
;
Wang, Lijun
;
Wang, Shuaiyu
;
Li, Xiangqian
  |  
收藏
  |  
浏览/下载:31/0
  |  
提交时间:2018/01/11
Thiosemicarbazone
Anticancer
2-(3
Apoptosis
4-difluorobenzylidene) Hydrazinecarbothioamide
Ros
Mitochondria-dependent Pathway
Discovery and evaluation of the hybrid of bromophenol and saccharide as potent and selective protein tyrosine phosphatase 1B inhibitors
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 134, 页码: 24-33
作者:
Zhang, Renshuai
;
Yu, Rilei
;
Xu, Qi
;
Li, Xiangqian
;
Luo, Jiao
收藏
  |  
浏览/下载:33/0
  |  
提交时间:2017/07/10
PTP1B
Bromophenol
Saccharide
Selectivity
Permeability
Design of antitumor agents containing carbohydrate based on GLUT1, and evaluation of antiproliferative activity
期刊论文
OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2017, 卷号: 27, 期号: 11, 页码: 2488-2492
作者:
Zhang, Renshuai
;
Song, Lairong
;
Jiang, Bo
;
Wang, Lijun
;
Wu, Ning
  |  
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2017/09/30
Saccharide
Glut1
Drug Design
Anticancer
Cell Uptake