中国科学院机构知识库网格
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Research progress on critical viral protease inhibitors for coronaviruses and enteroviruses
期刊论文
OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2025, 卷号: 122, 页码: 19
作者:
Hu, Shulei
;
Zhong, Qiuyu
;
Xie, Xiong
;
Zhang, Shurui
;
Wang, Jinlin
  |  
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2025/05/27
Innate immunity response
SARS-CoV-2 3CLpro
PLpro
EV71 3Cpro
2Apro
Viral protease inhibitor
Structure-Based Discovery of a Series of Novel MAT2a Inhibitors
期刊论文
OAI收割
ACS MEDICINAL CHEMISTRY LETTERS, 2025, 页码: 5
作者:
Zhou, Yushan
;
Wang, Li
;
Ren, Ruyue
;
Zhang, Junjie
  |  
收藏
  |  
浏览/下载:1/0
  |  
提交时间:2025/05/27
MAT2a
MTAP
Synthetic lethality
Allosteric inhibitor
Structure-activity relationship
Deep Learning Enhanced Near Infrared-II Imaging and Image-Guided Small Interfering Ribonucleic Acid Therapy of Ischemic Stroke
期刊论文
OAI收割
ACS NANO, 2025, 卷号: 19, 期号: 10, 页码: 10323-10336
作者:
Yu, Kai
;
Fu, Lidan
;
Chao, Yu
;
Zeng, Xiaodong
;
Zhang, Yonggang
  |  
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2025/04/24
ischemic stroke
small interferingRNA therapy
near-infrared II imaging
blood-brainbarrier
deep learning
Metal-organic frameworks (MOFs) for phototherapy and synergistic phototherapy of cancer
期刊论文
OAI收割
COORDINATION CHEMISTRY REVIEWS, 2025, 卷号: 526, 页码: 23
作者:
Tong, Pei-Hong
;
Yang, Jing-Jie
;
Zhou, Yu-Fan
;
Tang, Yi-Fan
;
Tang, Meng-Tian
  |  
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2025/02/28
Metal-organic frameworks (MOFs)
Phototherapy
Photodynamic therapy
Photothermal therapy
Synergistic therapy
Cancer
Identifying a non-conserved site for achieving allosteric covalent inhibition of CECR2
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2025, 页码: 16
作者:
Tang, Cai-ling
;
Li, Yuan-qing
;
Du, Xi-kun
;
Fang, Xiao-xia
;
Guang, Yi-man
  |  
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2025/04/01
dynamics simulation
CECR2
covalent inhibitor
allosteric effect
De Novo siRNA nanoplatform with NIR-II imaging for treatment of carotid atherosclerotic plaques
期刊论文
OAI收割
CHEMICAL ENGINEERING JOURNAL, 2025, 卷号: 503, 页码: 13
作者:
Gao, Jialu
;
Zhu, Hua
;
Cai, Huanhuan
;
Ding, Qihang
;
Xiong, Xiaoxing
  |  
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2025/02/28
siRNA delivery
Atheromatous plaques
NIR-II imaging
Multifunctional nanoplatform
Epsin1/2
Optimization and Biological Evaluation of Novel 1
H
-Pyrrolo[2,3-
c
]pyridin Derivatives as Potent and Reversible Lysine Specific Demethylase 1 Inhibitors for the Treatment of Acute Myelogenous Leukemia
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 67, 期号: 24, 页码: 22080-22103
作者:
Jiang, Hong
;
Li, Cong
;
Li, Na
;
Sheng, Li
;
Wang, Jingkai
  |  
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2025/01/14
Ruthenium(II)-Catalyzed Pyridyl-Directed Tryptophan C-H Acylmethylation with
α
-Chloro Ketones
期刊论文
OAI收割
ADVANCED SYNTHESIS & CATALYSIS, 2024, 页码: 7
作者:
Hu, Shulei
;
Wang, Yong
;
Xie, Xiong
;
Liang, Renwen
;
Liu, Hong
  |  
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2024/12/16
C-H functionalization
Ru(II)-catalyzed
Acylmethylation
alpha
-chloro ketones
Tryptophan-containing peptide
Design, synthesis, and biological evaluation of pyrido[2,3-d]pyrimidin-7 (8H)-one derivatives as potent USP1 inhibitors
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 275, 页码: 18
作者:
Li, Hongrui
;
Liu, Ben-Jin
;
Xu, Jiahao
;
Song, Shan-Shan
;
Ba, Ruixian
  |  
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2024/08/22
USP1 inhibitor
Structure -activity relationships
Olaparib-resistant cell
Rh(III)-catalyzed late-stage C-H alkenylation and macrolactamization for the synthesis of cyclic peptides with unique Trp(C7)-alkene crosslinks
期刊论文
OAI收割
CHINESE CHEMICAL LETTERS, 2024, 卷号: 35, 期号: 8, 页码: 8
作者:
Hu, Shulei
;
Zhang, Yu
;
Xie, Xiong
;
Li, Luhan
;
Chen, Kaixian
  |  
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2024/11/05
C -H functionalization
Rh(III)-catalyzed
Alkenylation
Cyclic peptides
Macrolactamization