机构

• 上海药物研究所 [13]
• 地理科学与资源研究所 [1]

采集方式

• OAI收割 [14]

内容类型

• 期刊论文 [14]

发表日期

• 2024 [1]
• 2023 [2]
• 2022 [1]
• 2021 [2]
• 2020 [3]
• 2018 [1]
• 更多

学科主题

筛选

浏览/检索结果: 共14条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择提交时间升序提交时间降序题名升序题名降序作者升序作者降序发表日期升序发表日期降序 Ecto-nucleotide pyrophosphatase/phosphodiesterase 1 inhibitors: Research progress and prospects 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 267, 页码: 13 作者:  Guan, Dezhong;  Fang, Lincheng;  Feng, Mingshun;  Guo, Shi;  Xie, Lingfeng   |  收藏  |  浏览/下载：1/0  |  提交时间：2024/05/07 ENPP1 inhibitors  cGAS-STING pathway  2 ', 3 '-cGAMP  Tumor immunotherapy   Design, synthesis and pharmacological evaluation of 2,3-dihydrobenzo-furan IRAK4 inhibitors for the treatment of diffuse large B-cell lymphoma 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 256, 页码: 16 作者:  Chen, Yun;  Ning, Yi;  Chen, Zhiwei;  Xue, Yaping;  Wu, Qingyun   |  收藏  |  浏览/下载：12/0  |  提交时间：2023/10/17 Apoptosis  Diffuse large B-Cell lymphoma  Interleukin-1 receptor associated kinase 4  Structure-based drug design  2  3-Dihydrobenzofuran   Design, synthesis and biological evaluation of KRASG12C-PROTACs 期刊论文  OAI收割 BIOORGANIC & MEDICINAL CHEMISTRY, 2023, 卷号: 78, 页码: 14 作者:     |  收藏  |  浏览/下载：13/0  |  提交时间：2023/04/10 KRASG12C  PROTAC  Covalent inhibitors  Structure-activity relationships (SARs)  Anticancer   Structural insights into a shared mechanism of human STING activation by a potent agonist and an autoimmune disease-associated mutation 期刊论文  OAI收割 CELL DISCOVERY, 2022, 卷号: 8, 期号: 1, 页码: 17 作者:  Xie, Zuoquan;  Wang, Zhen;  Fan, Fengying;  Zhou, Jinpei;  Hu, Zhaoxue   |  收藏  |  浏览/下载：22/0  |  提交时间：2023/04/10 Discovery and structure - activity relationship exploration of pyrazolo [1,5-a]pyrimidine derivatives as potent FLT3-ITD inhibitors 期刊论文  OAI收割 BIOORGANIC & MEDICINAL CHEMISTRY, 2021, 卷号: 48, 页码: 13 作者:  Chen, Yun;  Bai, Gang;  Li, Yan;  Ning, Yi;  Cao, Sufen   |  收藏  |  浏览/下载：58/0  |  提交时间：2021/12/01 FLT3  FLT3-ITD  Acute myeloid leukemia  Structure-activity relationships  Pyrazolo[1, 5-a]pyrimidine   Design, Synthesis, and Biological Evaluation of IRAK4-Targeting PROTACs 期刊论文  OAI收割 ACS MEDICINAL CHEMISTRY LETTERS, 2021, 卷号: 12, 期号: 1, 页码: 82-87 作者:  Chen, Yun;  Ning, Yi;  Bai, Gang;  Tong, Linjiang;  Zhang, Tao   |  收藏  |  浏览/下载：41/0  |  提交时间：2021/05/24 IRAK4  PROTAC  protein degrader  scaffolding role  diffuse large B-cell lymphoma   DW14006 as a direct AMPK alpha 1 activator improves pathology of AD model mice by regulating microglial phagocytosis and neuroinflammation 期刊论文  OAI收割 BRAIN BEHAVIOR AND IMMUNITY, 2020, 卷号: 90, 页码: 55-69 作者:  Lv, Jianlu;  Wang, Wei;  Zhu, Xialin;  Xu, Xiaoju;  Yan, Qiuying   |  收藏  |  浏览/下载：30/0  |  提交时间：2020/12/21 Alzheimer'sdisease  Microglia  AMPK alpha 1  DW14006  Phagocytosis  Neuro-inflammation   DW14006 as a Direct AMPK alpha Activator Ameliorates Diabetic Peripheral Neuropathy in Mice 期刊论文  OAI收割 DIABETES, 2020, 卷号: 69, 期号: 9, 页码: 1974-1988 作者:  Xu, Xu;  Wang, Wei;  Wang, Zhengyu;  Lv, Jianlu;  Xu, Xiaoju   |  收藏  |  浏览/下载：24/0  |  提交时间：2020/12/24 Design and synthesis of Imidazo[1,2-b]pyridazine IRAK4 inhibitors for the treatment of mutant MYD88 L265P diffuse large B-cell lymphoma 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 190, 页码: 14 作者:  Chen, Yun;  Bai, Gang;  Ning, Yi;  Cai, Shi;  Zhang, Tao   |  收藏  |  浏览/下载：42/0  |  提交时间：2020/07/01 lnterleukin-1 receptor associated kinase 4  Imidazol1,2-6]pyridazine  Diffuse large B-cell lymphoma  Drug design  Antitumor agents   TSPA as a novel ATF6 alpha translocation inducer efficiently ameliorates insulin sensitivity restoration and glucose homeostasis in db/db mice 期刊论文  OAI收割 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2018, 卷号: 499, 期号: 4, 页码: 948-953 作者:  Zhou, Tingting;  Cheng, Yanhua;  Yan, Wenzhong;  Shi, Xiaofan;  Xu, Xin   |  收藏  |  浏览/下载：32/0  |  提交时间：2019/01/08 ATF6 alpha  ER stress  insulin resistance  TSPA  T2DM