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浏览/检索结果: 共144条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序作者升序作者降序 Discovery of novel imidazo[2,1-b][1,3,4]thiadiazole analogs as fluorescent SHP2 inhibitors 期刊论文  OAI收割 BIOORGANIC CHEMISTRY, 2025, 卷号: 163, 页码: 10 作者:  Zhang, Chun;  Yan, Xue;  Gao, Li-Xin   |  收藏  |  浏览/下载：13/0  |  提交时间：2025/08/20 Imidazo[2,1-b][1,3,4]thiadiazole  Inhibitory activities  Fluorescence imaging  Zebrafish  SHP2   Synthesis, fluorescence properties of novel thiazolo[3,2-b][1,2,4]triazol derivatives as potent SHP2 inhibitors and its uses in sensing for Fe3+and cell imaging 期刊论文  OAI收割 JOURNAL OF MOLECULAR STRUCTURE, 2025, 卷号: 1324, 页码: 12 作者:  Yan, Xue;  Zhang, Chun;  Gao, Li-Xin;  Cao, Zi-Tong;  Gan, Su-Ya   |  收藏  |  浏览/下载：47/0  |  提交时间：2025/01/14 Thiazolo[3,2-b][1,2,4]triazole  Salicylic acid  Fe3+ion  Fluorescence property  SHP2   New chromone derivatives bearing thiazolidine-2,4-dione moiety as potent PTP1B inhibitors: Synthesis and biological activity evaluation 期刊论文  OAI收割 BIOORGANIC CHEMISTRY, 2024, 卷号: 143, 页码: 9 作者:  Zheng, Yingying;  Lu, Li;  Li, Mengyue;  Xu, Dehua;  Zhang, Laishun   |  收藏  |  浏览/下载：70/0  |  提交时间：2024/01/26 Chromone  Thiazolidine-2  4-dione  Protein tyrosine phosphatase 1B  Inhibitors   Design, synthesis and pharmacological evaluation of 2,3-dihydrobenzo-furan IRAK4 inhibitors for the treatment of diffuse large B-cell lymphoma 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 256, 页码: 16 作者:     |  收藏  |  浏览/下载：46/0  |  提交时间：2023/10/17 Apoptosis  Diffuse large B-Cell lymphoma  Interleukin-1 receptor associated kinase 4  Structure-based drug design  2  3-Dihydrobenzofuran   Dysregulation of iron homeostasis by TfR-1 renders EZH2 wild type diffuse large B-cell lymphoma resistance to EZH2 inhibition 期刊论文  OAI收割 ACTA PHARMACOLOGICA SINICA, 2023, 页码: 12 作者:  Yu, Lei   |  收藏  |  浏览/下载：51/0  |  提交时间：2023/10/17 diffuse large B-cell lymphoma  EZH2  TfR-1  GPX4  ferroptosis  HH2853   Identification of 1H-pyrazolo[3,4-b]pyridine derivatives as novel and potent TBK1 inhibitors: design, synthesis, biological evaluation, and molecular docking study 期刊论文  OAI收割 JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2022, 卷号: 37, 期号: 1, 页码: 1411-1425 作者:  Sun, Yin;  Tang, Haotian;  Wang, Xiaoyan;  Feng, Fang;  Fan, Tiantian   |  收藏  |  浏览/下载：86/0  |  提交时间：2022/08/16 TBK1 inhibitors  1H-pyrazolo[3  4-b]pyridine  structure-activity relationships (SARs)  immune response  cancer therapy   The Involvement of the Mammalian Target of Rapamycin, Protein Tyrosine Phosphatase 1b and Dipeptidase 4 Signaling Pathways in Cancer and Diabetes: A Narrative Review 期刊论文  OAI收割 MINI-REVIEWS IN MEDICINAL CHEMISTRY, 2021, 卷号: 21, 期号: 7, 页码: 803-815 作者:  Zhang, Jiajia;  Wu, Ning;  Shi, Dayong   |  收藏  |  浏览/下载：42/0  |  提交时间：2021/05/11 Signaling pathway  mammalian target of rapamycin  protein tyrosine phosphatase 1b  dipeptidase 4  cancer  diabetes  pharmacology  target compounds   Cloning and functional characterization of IRAK1 from rainbow trout (Oncorhynchus mykiss) 期刊论文  OAI收割 DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, 2021, 卷号: 114, 页码: 8 作者:  Yue Cong Yang   |  收藏  |  浏览/下载：204/0  |  提交时间：2020/12/31 IRAK1  NF-kappa B  MyD88  IRAK4  TRAF6  Rainbow trout   Design and synthesis of Imidazo[1,2-b]pyridazine IRAK4 inhibitors for the treatment of mutant MYD88 L265P diffuse large B-cell lymphoma 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 190, 页码: 14 作者:  Chen, Yun;  Bai, Gang;  Ning, Yi;  Cai, Shi;  Zhang, Tao   |  收藏  |  浏览/下载：72/0  |  提交时间：2020/07/01 lnterleukin-1 receptor associated kinase 4  Imidazol1,2-6]pyridazine  Diffuse large B-cell lymphoma  Drug design  Antitumor agents   The natural product antroalbol H promotes phosphorylation of liver kinase B1 (LKB1) at threonine 189 and thereby enhances cellular glucose uptake 期刊论文  OAI收割 JOURNAL OF BIOLOGICAL CHEMISTRY, 2019, 卷号: 294, 期号: 27, 页码: 10415-10427 作者:  Wang, Fang;  Yang, Xiaoyan;  Lu, Yanting;  Li, Zhenghui;  Xu, Yuhui   |  收藏  |  浏览/下载：99/0  |  提交时间：2019/09/10 glucose metabolism  liver kinase B1 (LKB1)  AMP-activated kinase (AMPK)  glucose transporter type 4 (GLUT4)  fungi  Basidiomycete  diabetes  energy sensing  glucose homeostasis  sesquiterpene