机构

• 上海药物研究所 [5]
• 合肥物质科学研究院 [2]
• 金属研究所 [1]

采集方式

• OAI收割 [8]

内容类型

• 期刊论文 [8]

发表日期

• 2018 [1]
• 2017 [1]
• 2016 [3]
• 2015 [1]
• 2014 [1]
• 2008 [1]
• 更多

学科主题

筛选

浏览/检索结果: 共8条，第1-8条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序作者升序作者降序 Design, synthesis and pharmacological evaluation of ALK and Hsp90 dual inhibitors bearing resorcinol and 2,4-diaminopyrimidine motifs 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 152, 页码: 76-86 作者:  Geng, Kaijun;  Liu, Hongchun;  Song, Zilan;  Zhang, Chi;  Zhang, Minmin   |  收藏  |  浏览/下载：194/0  |  提交时间：2019/01/08 Heat shock protein 90 (Hsp90)  Tyrosine kinase ALK  Dual inhibitor  Drug resistance  Antiproliferative activity   Discovery of N-(5-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-4-methoxy-2-(4-methyl-1,4-diazepan-1-yl)phenyl)acrylamide (CHMFL-ALK/EGFR-050) as a potent ALK/EGFR dual kinase inhibitor capable of overcoming a variety of ALK/EGFR associated drug resistant mutants in NSCLC 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 139, 期号: 无, 页码: 674-697 作者:  Chen, Yongfei;  Wu, Jiaxin   |  收藏  |  浏览/下载：1027/0  |  提交时间：2018/08/17 Egfr  Alk  Dual Kinase Inhibitor  Non-small Cell Lung Cancer   Metabolism-based structure optimization: Discovery of a potent and orally available tyrosine kinase ALK inhibitor bearing the tetracyclic benzo[b]carbazolone core 期刊论文  OAI收割 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2016, 卷号: 26, 期号: 22, 页码: 5399-5402 作者:  Han, Mei;  Wang, Chengyan;  Ji, Yinchun;  Song, Zilan;  Xing, Li   |  收藏  |  浏览/下载：79/0  |  提交时间：2019/01/08 EML4-ALK kinase  Oxidative metabolism  Benzo[b]carbazolone  hERG  Antitumor activity   An orally available tyrosine kinase ALK and RET dual inhibitor bearing the tetracyclic benzo[b]carbazolone core 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2016, 卷号: 118, 页码: 244-249 作者:  Song, Zilan;  Xia, Zongjun;  Ji, Yinchun;  Xing, Li;  Gao, Yinglei   |  收藏  |  浏览/下载：80/0  |  提交时间：2019/01/08 Benzo[b]carbazolones  ALK inhibitors  RET kinase  Antiresistance  Non-small-cell lung cancer  Preclinical study   Detection of ALK translocation in non-small cell lung carcinoma (NSCLC) and its clinicopathological significance using the Ventana immunohistochemical staining method: a single-center large-scale investigation of 1,504 Chinese Han patients 期刊论文  OAI收割 CHINESE JOURNAL OF CANCER RESEARCH, 2016, 卷号: 28 -   |  收藏  |  浏览/下载：63/0  |  提交时间：2020/10/26 EML4-ALK FUSION  CANCER  ADENOCARCINOMA  PCR  EXPERIENCE  FISH  GENE  Anaplastic lymphoma kinase (ALK) rearrangements  fully automated immunohistochemistry (IHC)  clinicopathological analysis  targeted therapy   Alectinib: a novel second generation anaplastic lymphoma kinase (ALK) inhibitor for overcoming clinically-acquired resistance 期刊论文  OAI收割 ACTA PHARMACEUTICA SINICA B, 2015, 卷号: 5, 期号: 1, 页码: 34-37 作者:  Song, Zilan;  Wang, Meining;  Zhang, Ao   |  收藏  |  浏览/下载：71/0  |  提交时间：2019/01/08 Tyrosine anaplastic lymphoma kinase  Alectinib  Crizotinib  Non-suaall cell lung cancer  Resistance ALK mutations  EML4-ALK   Design, synthesis and pharmacological evaluation of 2-(thiazol-2-amino)-4-arylaminopyrimidines as potent anaplastic lymphoma kinase (ALK) inhibitors 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2014, 卷号: 86, 页码: 438-448 作者:  Liu, Zhiqing;  Yue, Xihua;  Song, Zilan;  Peng, Xia;  Guo, Junfeng   |  收藏  |  浏览/下载：66/0  |  提交时间：2019/01/08 2-Aminothiazole  ALK kinase  Gatekeeper mutation  2,4-Diarylaminopyrimidine  Non-small-cell lung cancer   Synthesis and biological evaluation of novel 2,4,5-triaryl-1 H-pyrazol-3(2H)-ones as inhibitors of ALK5 期刊论文  OAI收割 CHINESE CHEMICAL LETTERS, 2008, 卷号: 19, 期号: 4, 页码: 379-382 作者:  Li Xing Zhou;  Dai Xian Ping;  Lai Kang Ying;  Wang Li Li;  Zheng Zhi Bing   |  收藏  |  浏览/下载：60/0  |  提交时间：2021/02/03 BETA  IDENTIFICATION  KINASE  activin-like kinases5 (ALK5)  kinase inhibitors  1H-pyrazol-3(2H)-ones