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浏览/检索结果: 共955条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择提交时间升序提交时间降序发表日期升序发表日期降序题名升序题名降序作者升序作者降序 Proteomics analysis of histone deacetylase inhibitor-resistant solid tumors reveals resistant signatures and potential drug combinations 期刊论文  OAI收割 ACTA PHARMACOLOGICA SINICA, 2024, 页码: 11 作者:  Hao, Bing-bing;  Ma, Ke;  Xu, Jun-yu;  Fan, Ru-feng;  Zhao, Wen-si   |  收藏  |  浏览/下载：14/0  |  提交时间：2024/03/25 solid tumor  histone deacetylase inhibitor  vorinostat (SAHA)  drug resistance  proteomics   Inulin-like polysaccharide ABWW may impede CCl4 induced hepatic stellate cell activation through mediating the FAK/PI3K/AKT signaling pathway in vitro & in vivo 期刊论文  OAI收割 CARBOHYDRATE POLYMERS, 2024, 卷号: 326, 页码: 15 作者:  Dai, Xiaolan;  Du, Zhenyun;  Jin, Can;  Tang, Bixi;  Chen, Xia   |  收藏  |  浏览/下载：11/0  |  提交时间：2024/02/19 Fructan  Hepatic fibrosis  Hepatic stellate cells  FAK/PI3K/AKT   Discovery of a 1,6-naphthyridin-4-one-based AXL inhibitor with improved pharmacokinetics and enhanced in vivo antitumor efficacy 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 265, 页码: 17 作者:  Lan, Yaohan;  Peng, Xia;  Ji, Yinchun;  Su, Yi;  Duan, Wenhu   |  收藏  |  浏览/下载：9/0  |  提交时间：2024/02/27 AXL inhibitor  In vivo antitumor efficacy  6-Naphthyridin-4-one derivatives  Scaffold hopping  Structure-based drug design   Discovery of a potent and selective covalent threonine tyrosine kinase (TTK) inhibitor 期刊论文  OAI收割 BIOORGANIC CHEMISTRY, 2024, 卷号: 143, 页码: 16 作者:  Sun, Yaoliang;  Chen, Zhiwen;  Liu, Guobin;  Chen, Xiaoai;  Shi, Zihan   |  收藏  |  浏览/下载：9/0  |  提交时间：2024/03/25 Inhibitor  Cancer  Threonine tyrosine kinase (TTK)  Covalent   Discovery, Optimization, and Evaluation of Novel Pyridin-2(1H)-one Analogues as Potent TRK Inhibitors for Cancer Treatment 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 67, 期号: 2, 页码: 1168-1183 作者:  Xu, Zichao;  Peng, Xia;  Zhang, Renjie;  Ji, Yinchun;  You, Mengke   |  收藏  |  浏览/下载：10/0  |  提交时间：2024/02/27 SIBP-03, a novel anti-HER3 antibody, exerts antitumor effects and synergizes with EGFR- and HER2-targeted drugs 期刊论文  OAI收割 ACTA PHARMACOLOGICA SINICA, 2024, 页码: 10 作者:  Li, Wen-jing;  Xie, Cheng-ying;  Zhu, Xi;  Tang, Jiao;  Wang, Lei   |  收藏  |  浏览/下载：4/0  |  提交时间：2024/02/19 SIBP-03  HER3  HER3-targeted therapy  neuregulin 1  EGFR  HER2   Structure-based optimization of indoline-containing compounds as second generation inhibitors of NF-KB-inducing kinase (NIK) 期刊论文  OAI收割 JOURNAL OF MOLECULAR STRUCTURE, 2024, 卷号: 1295, 页码: 19 作者:  Cheng, Jing;  Yan, Ziqin;  Li, Xinzhi;  Liu, Chen;  Tong, Linjiang   |  收藏  |  浏览/下载：8/0  |  提交时间：2023/12/08 Kinase inhibitor  NIK  NF-KB2  Indoline  COT  Cytotoxicity   Discovery and optimization of thieno[3,2-d]pyrimidine derivatives as highly selective inhibitors of cyclin-dependent kinase 7 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 263, 页码: 21 作者:  Zhang, Hongjin;  Lin, Guohao;  Jia, Suyun;  Zhang, Ying;  Wu, Jianbo   |  收藏  |  浏览/下载：5/0  |  提交时间：2024/01/26 Thieno[3  d ]pyrimidine derivative  Cyclin-dependent kinase 7  Small molecule inhibitor  Kinome selectivity  Triple negative breast cancer   Discovery of hematopoietic progenitor kinase 1 inhibitors using machine learning-based screening and free energy perturbation 期刊论文  OAI收割 JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, 2024, 页码: 13 作者:  Feng, Dazhi;  Liu, Bo;  Chen, Zhiwei;  Xu, Jinyi;  Geng, Meiyu   |  收藏  |  浏览/下载：25/0  |  提交时间：2024/02/27 HPK1 inhibitor  machine learning  virtual screening  free energy perturbation  structural modification   Structure-based development of potent and selective type-II kinase inhibitors of RIPK1 期刊论文  OAI收割 ACTA PHARMACEUTICA SINICA B, 2024, 卷号: 14, 期号: 1, 页码: 319-334 作者:  Qin, Ying;  Li, Dekang;  Qi, Chunting;  Xiang, Huaijiang;  Meng, Huyan   |  收藏  |  浏览/下载：6/0  |  提交时间：2024/03/06 RIPK1  Necroptosis  Type-II kinase inhibitors  Rational design  Lead optimization  Structure-activity relationship  Anti-inflammation  Preclinical drug discovery