中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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上海药物研究所 [67]
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期刊论文 [278]
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Development of a bispecific antibody-drug conjugate targeting EpCAM and CLDN3 for the treatment of multiple solid tumors
期刊论文
OAI收割
EXPERIMENTAL HEMATOLOGY & ONCOLOGY, 2025, 卷号: 14, 期号: 1, 页码: 16
作者:
Luo, Meiying
;
Wang, Xiaohuan
;
Yu, Guoji
;
Ji, Jing
;
Li, Long
  |  
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2025/04/07
EpCAM
CLDN3
Antibody-drug conjugate
Dxd
Solid tumor
Simultaneous Quantification of Total Antibody and Conjugated Payload for DS001 in Rat Serum Using a Hybrid Immuno-Capture LC-MS/MS
期刊论文
OAI收割
AAPS JOURNAL, 2025, 卷号: 27, 期号: 1, 页码: 13
作者:
Yu, Xiong
;
Li, Weiqiang
;
Huang, Wensi
;
Xiao, Bo
;
Long, Jing
  |  
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2025/04/01
ADC
LC-MS/MS
payload
simultaneous quantification
total antibody
Intratumoral lactic acid neutralization strategy for boosting chemoimmunotherapy using liposomal sodium bicarbonate
期刊论文
OAI收割
SCIENCE BULLETIN, 2024, 卷号: 69, 期号: 24, 页码: 3936-3948
作者:
Peng, Taoxing
;
Shao, Xinyue
;
Song, Wenqin
;
Xu, Weihua
;
Xiong, Wei
  |  
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2025/04/01
Sodium bicarbonate
Lactic acid neutralization
Tumor microenvironment normalization
Chemoimmunotherapy
PD-1 antibody
Ion-trapping barrier
AI-driven antibody design with generative diffusion models: current insights and future directions
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2024, 页码: 10
作者:
He, Xin-heng
;
Li, Jun-rui
;
Xu, James
;
Shan, Hong
;
Shen, Shi-yi
  |  
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2024/11/05
antibodies
generative model
diffusion
de novo antibody design
CDR optimization
model evaluation
1
H,
13
C and
15
N resonance assignments of a shark variable new antigen receptor against hyaluronan synthase
期刊论文
OAI收割
BIOMOLECULAR NMR ASSIGNMENTS, 2024, 页码: 5
作者:
Liu, Yuxin
;
Wang, Hao
;
Chiu, Cookson K. C.
;
Wu, Yujie
;
Bi, Yunchen
  |  
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2024/12/20
Single domain antibody
VNAR
NMR spectroscopy assignments
Design and synthesis of novel site-specific antibody-drug conjugates that target TROP2
期刊论文
OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY, 2024, 卷号: 110, 页码: 16
作者:
Luo, Caili
;
Ren, Anni
;
Jin, Zixuan
;
Zhang, Jianxin
;
Shi, Wei
  |  
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2024/08/22
TROP2
Antibody-drug conjugate (ADC)
Site-specific
Glycoengineering
Affinity-directed conjugation
Epigenetic Reprogramming Potentiates ICAM1 Antibody Drug Conjugates in Preclinical Models of Melanoma
期刊论文
OAI收割
ADVANCED SCIENCE, 2024, 卷号: 11
作者:
Zhang, Peng
;
Tao, Changjuan
;
Lu, Ye
;
Li, Peijing
;
Wang, Xing
  |  
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2024/11/20
antibody drug conjugate
decitabine
ICAM1
melanoma
targeted therapy
Comparison of "framework Shuffling" and "CDR Grafting" in humanization of a PD-1 murine antibody
期刊论文
OAI收割
FRONTIERS IN IMMUNOLOGY, 2024, 卷号: 15, 页码: 16
作者:
Wang, Yongmei
;
Chen, Yi-Li
;
Xu, Hui
;
Rana, Gul E.
;
Tan, Xiaorong
  |  
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2024/09/26
antibody humanization
programmed death-1
FR shuffling
CDR grafting
immunogenicity
Development of an ELISA with acidification treatment for an antibody conjugate incorporating Exatecans
期刊论文
OAI收割
ANALYTICAL BIOCHEMISTRY, 2024, 卷号: 690, 页码: 8
作者:
Zhang, Yingying
;
Yun, Xi
;
Ouyang, Lu
;
Zhang, Xianjing
;
Gong, Likum
  |  
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2024/06/27
Antibody-drug conjugate
Camptothecin
Exatecan
Bioanalysis
Pharmacokinetics
Structure-Based Optimization of One Neutralizing Antibody against SARS-CoV-2 Variants Bearing the L452R Mutation
期刊论文
OAI收割
VIRUSES-BASEL, 2024, 卷号: 16, 期号: 4, 页码: 9
作者:
Chen, Yamin
;
Zha, Jialu
;
Xu, Shiqi
;
Shao, Jiang
;
Liu, Xiaoshan
  |  
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2024/05/31
COVID-19
neutralizing antibody
structure-based antibody optimization
L452R mutation