中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
机构
上海药物研究所 [30]
合肥物质科学研究院 [8]
海洋研究所 [5]
上海生物化学与细胞生... [4]
长春应用化学研究所 [4]
上海营养与健康研究所 [3]
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OAI收割 [66]
内容类型
期刊论文 [62]
学位论文 [3]
CNKI期刊论文 [1]
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2025 [2]
2024 [3]
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2022 [2]
2021 [7]
2020 [3]
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浏览/检索结果:
共66条,第1-10条
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Discovery of 2,4-quinazolinedione derivatives as LC3B recruiters in the facilitation of protein complex degradations
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 287, 页码: 10
作者:
Zeng, Yanping
;
Xiao, Jian
;
Shi, Li
;
Li, Yangsha
;
Xu, Yuanxin
  |  
收藏
  |  
浏览/下载:38/0
  |  
提交时间:2025/04/01
LC3B
CDK9
Degradation
Protein complex
BET inhibitor and CDK4/6 inhibitor synergistically inhibit breast cancer by suppressing BRD4 stability and DNA damage repair
期刊论文
OAI收割
TRANSLATIONAL ONCOLOGY, 2025, 卷号: 51, 页码: 11
作者:
Chi, Shuaishuai
;
Wei, Fan
;
Li, Yangsha
;
Yu, Lei
;
Ma, Chuyao
  |  
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2025/01/06
CDK4
BRD4
Breast cancer
Protein stability
DNA damage
Unraveling the CDK9/PP2A/ERK Network in Transcriptional Pause Release and Complement Activation in KRAS-mutant Cancers
期刊论文
OAI收割
ADVANCED SCIENCE, 2024, 页码: 20
作者:
Wang, Yafang
;
Xu, Lansong
  |  
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2024/10/21
KRAS
CDK9
ERK
complement activation
immunosuppression
Discovery of novel CDK9 inhibitor with tridentate ligand: Design, synthesis and biological evaluation
期刊论文
OAI收割
BIOORGANIC CHEMISTRY, 2024, 卷号: 150, 页码: 12
作者:
Zhong, Ye
;
Xu, Jing
;
Ding, Shaoyue
;
Cao, Huiying
;
Zhang, Yufei
  |  
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2024/08/22
CDK9
Inhibitor
Colorectal cancer
Apoptosis
Tridentate ligand
Design, Synthesis, and Biological Evaluation of 2,4-Diaminopyrimidine Derivatives as Potent CDK7 Inhibitors
期刊论文
OAI收割
ACS MEDICINAL CHEMISTRY LETTERS, 2024, 页码: 8
作者:
Zhang, Hualin
;
Tu, Yutong
;
Tao, Zhaofan
;
Gao, Lixin
;
Huang, Shengjie
  |  
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2024/08/22
CDK7 inhibitor
2,4-diaminopyrimidine
selectivity
anticancer
The anticancer potential of chemical constituents of Moringa oleifera targeting CDK-2 inhibition in estrogen receptor positive breast cancer using in-silico and in vitro approches
期刊论文
OAI收割
BMC COMPLEMENTARY MEDICINE AND THERAPIES, 2023, 卷号: 23, 期号: 1, 页码: 17
作者:
Sultan, Rida
;
Ahmed, Abrar
;
Wei, Li
;
Saeed, Hamid
;
Islam, Muhammad
  |  
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2023/12/19
CDK2
ER+ Breast cancer
Molecular Docking
MM-GBSA
Molecular Dynamic Simulations
MTT assay
Moringa oleifera
Phytoconstituents
Chlorogenic acid
LINC00955 suppresses colorectal cancer growth by acting as a molecular scaffold of TRIM25 and Sp1 to Inhibit DNMT3B-mediated methylation of the PHIP promoter
期刊论文
OAI收割
BMC CANCER, 2023, 卷号: 23, 期号: 1, 页码: 20
作者:
Ren, Ganglin
;
Li, Hongyan
;
Hong, Dan
;
Hu, Fangyu
;
Jin, Rongjia
  |  
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2023/12/08
LINC00955
Colorectal cancer
Cell cycle
CDK2
PHIP
Sp1
Predicting and overcoming resistance to CDK9 inhibitors for cancer therapy
期刊论文
OAI收割
ACTA PHARMACEUTICA SINICA B, 2023, 卷号: 13
作者:
Hua, Chen
;
Shena, Lijuan
;
Zoua, Fengming
;
Wua, Yun
;
Wanga, Beilei
  |  
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2023/11/10
Acquired resistance mutations
CDK9 inhibitors
Transcription
Single nucleotide polymorphisms
BAY1251152
Discovery of HyT-Based Degraders of CDK9-Cyclin T1 Complex
期刊论文
OAI收割
CHEMISTRY & BIODIVERSITY, 2023, 页码: 10
作者:
Lin, Rongkun
;
Yang, Jie
;
Liu, Ting
;
Wang, Mingyu
  |  
收藏
  |  
浏览/下载:40/0
  |  
提交时间:2023/10/17
CDK9
cyclin T1
degrader
hydrophobic tag
protein degradation
New Monoterpenoid Indole Alkaloids from Tabernaemontana crassa Inhibit beta-Amyloid42 Production and Phospho-Tau (Thr217)
期刊论文
OAI收割
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 卷号: 24, 期号: 2, 页码: 1487
作者:
Li,Sheng
;
Han,Ling-Ling
;
Huang,Ke-Pu
;
Ma,Ye-Han
;
Guo,Ling-Li
  |  
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2024/05/09
Tabernaemontana crassa
monoterpenoid indole alkaloids
A beta 42
phospho-tau (Thr217)
Alzheimer's disease
ALZHEIMERS-DISEASE
BISINDOLE ALKALOIDS
CDK5
GEMFIBROZIL
PREVENTION
ALGORITHM
AUTOPHAGY
MODELS
PLANTS
MOUSE