中国科学院机构知识库网格
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上海药物研究所 [36]
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期刊论文 [68]
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Pharmacokinetics, mass balance, and metabolism of [
14
C]FCN-437c, a selective and potent CDK4/6 inhibitor in humans
期刊论文
OAI收割
CANCER CHEMOTHERAPY AND PHARMACOLOGY, 2025, 卷号: 95, 期号: 1, 页码: 12
作者:
Gao, Lei
;
Ma, Sheng
;
Yan, Shu
;
Zhang, Hua
;
Tian, Ling
  |  
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Design and synthesis of CDK9/EZH2 dual-target inhibitors to achieve synergistic antitumor effects
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 294, 页码: 14
作者:
Tian, Lina
;
Xiao, Jian
;
Zeng, Yanping
;
Li, Yangsha
;
Wei, Aihuan
  |  
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  |  
Fulcrum Occupancy-Leverage Perturbation Strategy Enables Rapid Discovery of Potent CDK2-Cyclin A2 Interaction Inhibitors
期刊论文
OAI收割
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2025, 页码: 14
作者:
Sun, Ge
;
Chi, Shuaishuai
;
Li, Jiacheng
;
Xu, Pan
;
Lin, Tingting
  |  
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Discovery of a ubiquitin-specific protease 10 inhibitor with high binding affinity promoting cell apoptosis via down-regulated CDK4 for the treatment of hepatocellular carcinoma
期刊论文
OAI收割
BIOORGANIC CHEMISTRY, 2025, 卷号: 163, 页码: 17
作者:
Lu, Yang
;
Wang, Wentao
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Design, synthesis and bio-evaluation of 2,5-disubstituted thiazole derivatives for potential treatment of acute myeloid leukemia through targeting CDK9
期刊论文
OAI收割
BIOORGANIC CHEMISTRY, 2025, 卷号: 160, 页码: 16
作者:
Chen, Sumeng
;
Huang, Jindi
;
Zhang, Shipeng
;
Zheng, Xinni
;
Chen, Hongming
  |  
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First ATG101-recruiting small molecule degrader for selective CDK9 degradation
via
autophagy-lysosome pathway
期刊论文
OAI收割
ACTA PHARMACEUTICA SINICA B, 2025, 卷号: 15, 期号: 5, 页码: 2612-2624
作者:
Zhong, Ye
;
Xu, Jing
;
Cao, Huiying
;
Gao, Jie
;
Ding, Shaoyue
  |  
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  |  
Discovery of 2,4-quinazolinedione derivatives as LC3B recruiters in the facilitation of protein complex degradations
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 287, 页码: 10
作者:
Zeng, Yanping
;
Xiao, Jian
;
Shi, Li
;
Li, Yangsha
;
Xu, Yuanxin
  |  
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  |  
BET inhibitor and CDK4/6 inhibitor synergistically inhibit breast cancer by suppressing BRD4 stability and DNA damage repair
期刊论文
OAI收割
TRANSLATIONAL ONCOLOGY, 2025, 卷号: 51, 页码: 11
作者:
Chi, Shuaishuai
;
Wei, Fan
;
Li, Yangsha
;
Yu, Lei
;
Ma, Chuyao
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Unraveling the CDK9/PP2A/ERK Network in Transcriptional Pause Release and Complement Activation in KRAS-mutant Cancers
期刊论文
OAI收割
ADVANCED SCIENCE, 2024, 页码: 20
作者:
Wang, Yafang
;
Xu, Lansong
;
Ling, Lijun
;
Yao, Mingyue
;
Shi, Shangxuan
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Discovery of novel CDK9 inhibitor with tridentate ligand: Design, synthesis and biological evaluation
期刊论文
OAI收割
BIOORGANIC CHEMISTRY, 2024, 卷号: 150, 页码: 12
作者:
Zhong, Ye
;
Xu, Jing
;
Ding, Shaoyue
;
Cao, Huiying
;
Zhang, Yufei
  |  
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