机构

• 上海药物研究所 [9]
• 合肥物质科学研究院 [1]

采集方式

• OAI收割 [10]

内容类型

• 期刊论文 [10]

发表日期

• 2025 [3]
• 2024 [2]
• 2021 [2]
• 2018 [2]
• 2017 [1]

学科主题

筛选

浏览/检索结果: 共10条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择提交时间升序提交时间降序作者升序作者降序题名升序题名降序发表日期升序发表日期降序 Pharmacokinetics, mass balance, and metabolism of [14C]FCN-437c, a selective and potent CDK4/6 inhibitor in humans 期刊论文  OAI收割 CANCER CHEMOTHERAPY AND PHARMACOLOGY, 2025, 卷号: 95, 期号: 1, 页码: 12 作者:  Gao, Lei;  Ma, Sheng;  Yan, Shu;  Zhang, Hua;  Tian, Ling   |  收藏  |  浏览/下载：22/0  |  提交时间：2025/07/25 FCN-437c  CDK4/6 inhibitor  Mass balance  Radiopharmacokinetics  Drug metabolism   Design and synthesis of CDK9/EZH2 dual-target inhibitors to achieve synergistic antitumor effects 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 294, 页码: 14 作者:  Tian, Lina;  Xiao, Jian   |  收藏  |  浏览/下载：9/0  |  提交时间：2025/08/20 CDK9  EZH2  Dual target inhibitor  DLBCL   Design, synthesis and bio-evaluation of 2,5-disubstituted thiazole derivatives for potential treatment of acute myeloid leukemia through targeting CDK9 期刊论文  OAI收割 BIOORGANIC CHEMISTRY, 2025, 卷号: 160, 页码: 16 作者:  Chen, Sumeng;  Huang, Jindi;  Zhang, Shipeng;  Zheng, Xinni;  Chen, Hongming   |  收藏  |  浏览/下载：21/0  |  提交时间：2025/06/23 CDK9  Inhibitor  Acute myeloid leukemia  Binding mode  Cellular mechanism   Discovery of novel CDK9 inhibitor with tridentate ligand: Design, synthesis and biological evaluation 期刊论文  OAI收割 BIOORGANIC CHEMISTRY, 2024, 卷号: 150, 页码: 12 作者:  Zhong, Ye;  Xu, Jing;  Ding, Shaoyue;  Cao, Huiying;  Zhang, Yufei   |  收藏  |  浏览/下载：54/0  |  提交时间：2024/08/22 CDK9  Inhibitor  Colorectal cancer  Apoptosis  Tridentate ligand   Design, Synthesis, and Biological Evaluation of 2,4-Diaminopyrimidine Derivatives as Potent CDK7 Inhibitors 期刊论文  OAI收割 ACS MEDICINAL CHEMISTRY LETTERS, 2024, 页码: 8 作者:  Zhang, Hualin;  Tu, Yutong;  Tao, Zhaofan;  Gao, Lixin;  Huang, Shengjie   |  收藏  |  浏览/下载：35/0  |  提交时间：2024/08/22 CDK7 inhibitor  2,4-diaminopyrimidine  selectivity  anticancer   Acid-activatible micelleplex delivering siRNA-PD-L1 for improved cancer immunotherapy of CDK4/6 inhibition 期刊论文  OAI收割 CHINESE CHEMICAL LETTERS, 2021, 卷号: 32, 期号: 6, 页码: 1929-1936 作者:  Gao, Jing;  Zhang, Hanwu;  Zhou, Fengqi;  Hou, Bo;  Chen, Meiwan   |  收藏  |  浏览/下载：74/0  |  提交时间：2021/08/17 Cancer immunotherapy  siRNA delivery  Acid-activatible micelleplex  CDK4  6 inhibitor  PD-L1 knockdown   Design, synthesis, and biological evaluation of 4-benzoylamino-1H-pyrazole-3-carboxamide derivatives as potent CDK2 inhibitors 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 215, 页码: 12 作者:  Lin, Tingting;  Li, Jiacheng   |  收藏  |  浏览/下载：58/0  |  提交时间：2021/05/24 CDK2 inhibitor  Selectivity  Anti-proliferative potency   Discovery of 4-(((4-(5-chloro-2-(((1s,4s)-4-((2-methoxyethyl)amino) cyclohexyl)amino)pyridin-4-yl)thiazol-2-yl)amino)methyl) tetrahydro-2H-pyran-4-carbonitrile (JSH-150) as a novel highly selective and potent CDK9 kinase inhibitor 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 158, 页码: 896-916 作者:  Wang, Beilei;  Wu, Jiaxin;  Wu, Yun;  Chen, Cheng;  Zou, Fengming   |  收藏  |  浏览/下载：85/0  |  提交时间：2019/12/25 CDK9  Kinase inhibitor  Structure-activity relationship  Leukemia   Design, synthesis, and molecular docking study of 3H-imidazole[4,5-c]pyridine derivatives as CDK2 inhibitors 期刊论文  OAI收割 ARCHIV DER PHARMAZIE, 2018, 卷号: 351, 期号: 6 作者:  Wu, Yi-Zhe;  Ying, Hua-Zhou;  Xu, Lei;  Cheng, Gang;  Chen, Jing   |  收藏  |  浏览/下载：50/0  |  提交时间：2019/01/08 cancer  CDK2 inhibitor  imidazo[4  5-c]pyridine  targeted therapy   Discovery of a class of diheteroaromatic amines as orally bioavailable CDK1/4/6 inhibitors 期刊论文  OAI收割 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2017, 卷号: 27, 期号: 23, 页码: 5332-5336 作者:  Fu, Yan;  Tang, Shuai;  Su, Yi;  Lan, Xiaojing;  Ye, Yan   |  收藏  |  浏览/下载：47/0  |  提交时间：2019/01/08 Cyclin-dependent kinase  CDK inhibitor  Structure-activity relationship  In vitro and in vivo profiling