机构

• 上海药物研究所 [13]
• 合肥物质科学研究院 [2]
• 上海营养与健康研究所 [1]

采集方式

• OAI收割 [16]

内容类型

• 期刊论文 [16]

发表日期

• 2025 [4]
• 2024 [2]
• 2023 [2]
• 2022 [1]
• 2021 [2]
• 2019 [2]
• 更多

学科主题

• Biochemist... [1]
• Biophysics [1]

筛选

浏览/检索结果: 共16条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择提交时间升序提交时间降序作者升序作者降序题名升序题名降序发表日期升序发表日期降序 Design and synthesis of CDK9/EZH2 dual-target inhibitors to achieve synergistic antitumor effects 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 294, 页码: 14 作者:  Tian, Lina;  Xiao, Jian;  Zeng, Yanping;  Li, Yangsha;  Wei, Aihuan   |  收藏  |  浏览/下载：1/0  |  提交时间：2025/08/20 CDK9  EZH2  Dual target inhibitor  DLBCL   Design, synthesis and bio-evaluation of 2,5-disubstituted thiazole derivatives for potential treatment of acute myeloid leukemia through targeting CDK9 期刊论文  OAI收割 BIOORGANIC CHEMISTRY, 2025, 卷号: 160, 页码: 16 作者:  Chen, Sumeng;  Huang, Jindi;  Zhang, Shipeng;  Zheng, Xinni;  Chen, Hongming   |  收藏  |  浏览/下载：16/0  |  提交时间：2025/06/23 CDK9  Inhibitor  Acute myeloid leukemia  Binding mode  Cellular mechanism   First ATG101-recruiting small molecule degrader for selective CDK9 degradation via autophagy-lysosome pathway 期刊论文  OAI收割 ACTA PHARMACEUTICA SINICA B, 2025, 卷号: 15, 期号: 5, 页码: 2612-2624 作者:  Zhong, Ye;  Xu, Jing;  Cao, Huiying;  Gao, Jie;  Ding, Shaoyue   |  收藏  |  浏览/下载：17/0  |  提交时间：2025/07/25 Protein degradation  Hydrophobic tags  ATG101  Autophagy-lysosome pathway  CDK9  Cyclin T1  Degrader  Antitumor   Discovery of 2,4-quinazolinedione derivatives as LC3B recruiters in the facilitation of protein complex degradations 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 287, 页码: 10 作者:  Zeng, Yanping;  Xiao, Jian;  Shi, Li;  Li, Yangsha;  Xu, Yuanxin   |  收藏  |  浏览/下载：75/0  |  提交时间：2025/04/01 LC3B  CDK9  Degradation  Protein complex   Unraveling the CDK9/PP2A/ERK Network in Transcriptional Pause Release and Complement Activation in KRAS-mutant Cancers 期刊论文  OAI收割 ADVANCED SCIENCE, 2024, 页码: 20 作者:  Wang, Yafang;  Xu, Lansong;  Ling, Lijun;  Yao, Mingyue;  Shi, Shangxuan   |  收藏  |  浏览/下载：35/0  |  提交时间：2024/10/21 KRAS  CDK9  ERK  complement activation  immunosuppression   Discovery of novel CDK9 inhibitor with tridentate ligand: Design, synthesis and biological evaluation 期刊论文  OAI收割 BIOORGANIC CHEMISTRY, 2024, 卷号: 150, 页码: 12 作者:  Zhong, Ye;  Xu, Jing;  Ding, Shaoyue;  Cao, Huiying;  Zhang, Yufei   |  收藏  |  浏览/下载：51/0  |  提交时间：2024/08/22 CDK9  Inhibitor  Colorectal cancer  Apoptosis  Tridentate ligand   Predicting and overcoming resistance to CDK9 inhibitors for cancer therapy 期刊论文  OAI收割 ACTA PHARMACEUTICA SINICA B, 2023, 卷号: 13 作者:  Hua, Chen;  Shena, Lijuan;  Zoua, Fengming;  Wua, Yun   |  收藏  |  浏览/下载：37/0  |  提交时间：2023/11/10 Acquired resistance mutations  CDK9 inhibitors  Transcription  Single nucleotide polymorphisms  BAY1251152   Discovery of HyT-Based Degraders of CDK9-Cyclin T1 Complex 期刊论文  OAI收割 CHEMISTRY & BIODIVERSITY, 2023, 页码: 10 作者:  Lin, Rongkun;  Yang, Jie;  Liu, Ting;  Wang, Mingyu;  Ke, Chongrong   |  收藏  |  浏览/下载：50/0  |  提交时间：2023/10/17 CDK9  cyclin T1  degrader  hydrophobic tag  protein degradation   Inhibition of the dopamine transporter promotes lysosome biogenesis and ameliorates Alzheimer's disease-like symptoms in mice 期刊论文  OAI收割 ALZHEIMERS & DEMENTIA, 2022, 页码: 15 作者:  Yin, Limin;  Zhou, Jianhui;  Li, Tianyou;  Wang, Xinghua;  Xue, Wenlong   |  收藏  |  浏览/下载：99/0  |  提交时间：2022/11/11 Alzheimer's disease  CDK9  dopamine transporter  lysosome biogenesis  TFEB   Efficient Synthesis and Docking Analysis of Selective CDK9 Inhibitor NVP-2 期刊论文  OAI收割 Pharmaceutical Fronts, 2021, 期号: 3, 页码: E50-E55 作者:  Saidahmatov, Abdusaid;  Liang, Xue-Wu;  Shi, Yuqiang;  Han, Xu;  Liu, Hong   |  收藏  |  浏览/下载：23/0  |  提交时间：2024/03/14 NVP-2  CDK9 inhitor  efficient synthesis  docking analysis