中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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上海药物研究所 [55]
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In vitro inhibition of six active sesquiterpenoids in zedoary turmeric oil on human liver cytochrome P450 enzymes
期刊论文
OAI收割
JOURNAL OF ETHNOPHARMACOLOGY, 2024, 卷号: 322, 页码: 10
作者:
Liu, Suyan
;
Zhao, Yong
;
Tang, Xuan
;
Yang, Junling
;
Pan, Chen
  |  
收藏
  |  
浏览/下载:46/0
  |  
提交时间:2024/02/27
Sesquiterpenoids
Inhibition
CYP450s
Drug-drug interactions
Mechanism
Design, synthesis and biological evaluation of chalcone derivatives as potent and orally active hCYP3A4 inhibitors
期刊论文
OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2023, 卷号: 95, 页码: 9
作者:
Lu, Shiwei
;
Zhang, Feng
;
Gong, Jiahao
;
Huang, Jian
;
Zhu, Guanghao
  |  
收藏
  |  
浏览/下载:37/0
  |  
提交时间:2023/12/08
Cytochrome P450 3A4 (CYP3A4)
Inhibitors
Isoquinoline chalcones
Orally active
牙鲆芳香化酶Cyp19a多克隆抗体制备及其应用
CNKI期刊论文
OAI收割
2022
作者:
舒畅
;
王丽娟
;
邹聪聪
;
邹玉霞
;
王国玉
  |  
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2024/12/18
牙鲆(Paralichthys olivaceus)
Cyp19a
重组蛋白
多克隆抗体
蛋白表达
Identification of a novel CYP4V gene in the polychaete Perinereis aibuhitensis: transcriptional comparison with a CYP4B gene exposed to PAHs
期刊论文
OAI收割
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH, 2022, 页码: 12
作者:
Zhao, Huan
;
Wang, Lili
;
Lei, Yan
;
Wang, Yinan
;
Yang, Dazuo
  |  
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2024/11/15
Polychaete
Perinereis aibuhitensis
PAHs
CYP
Liaohe Estuary
Identification of a novel CYP4V gene in the polychaete Perinereis aibuhitensis: transcriptional comparison with a CYP4B gene exposed to PAHs
期刊论文
OAI收割
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH, 2022, 页码: 12
作者:
Zhao, Huan
;
Wang, Lili
;
Lei, Yan
;
Wang, Yinan
;
Yang, Dazuo
  |  
收藏
  |  
浏览/下载:39/0
  |  
提交时间:2022/08/13
Polychaete
Perinereis aibuhitensis
PAHs
CYP
Liaohe Estuary
Metabolic map of the antiviral drug podophyllotoxin provides insights into hepatotoxicity
期刊论文
OAI收割
XENOBIOTICA, 2021, 页码: 13
作者:
Sun, Dongxue
;
Gao, Xiaoxia
;
Wang, Qiao
;
Krausz, Kristopher W.
;
Fang, Zhongze
  |  
收藏
  |  
浏览/下载:64/0
  |  
提交时间:2021/11/04
CYP
podophyllotoxin metabolism
liver microsomes
recombinant drug-metabolizing enzymes
hepatic and intestinal toxicity
Itraconazole and rifampicin, as CYP3A modulators but not P-gp modulators, affect the pharmacokinetics of almonertinib and active metabolite HAS-719 in healthy volunteers
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 9
作者:
Liu, Lu
;
Li, Wei
;
Yang, Le
;
Guo, Zi-tao
;
Xue, Hao
  |  
收藏
  |  
浏览/下载:85/0
  |  
提交时间:2021/08/17
almonertinib
itraconazole
rifampicin
drug metabolism
drug interaction
CYP3A
P-gp
pharmacokinetics
Effects of rifampicin on the pharmacokinetics of alflutinib, a selective third-generation EGFR kinase inhibitor, and its metabolite AST5902 in healthy volunteers
期刊论文
OAI收割
INVESTIGATIONAL NEW DRUGS, 2021, 页码: 8
作者:
Zhu, Yun-ting
;
Zhang, Yi-fan
;
Jiang, Jin-fang
;
Yang, Yong
;
Guo, Li-xia
  |  
收藏
  |  
浏览/下载:46/0
  |  
提交时间:2021/05/24
Alflutinib
Rifampicin
CYP3A4
AST5902
Drug-drug interaction
Zebrafish cyp11c1 Knockout Reveals the Roles of 11-ketotestosterone and Cortisol in Sexual Development and Reproduction
期刊论文
OAI收割
ENDOCRINOLOGY, 2020, 卷号: 161, 期号: 6, 页码: 20
作者:
Zhang, Qifeng
;
Ye, Ding
;
Wang, Houpeng
;
Wang, Yaqing
;
Hu, Wei
  |  
收藏
  |  
浏览/下载:53/0
  |  
提交时间:2020/10/12
zebrafish
cyp11c1
11-KT
cortisol
testis differentiation
spermatogenesis
ovulation
Effects of Apatinib on the Pharmacokinetics of Nifedipine and Warfarin in Patients with Advanced Solid Tumors
期刊论文
OAI收割
DRUG DESIGN DEVELOPMENT AND THERAPY, 2020, 卷号: 14, 页码: 1963-1970
作者:
Zhu, Yun-Ting
;
Teng, Zan
;
Zhang, Yi-Fan
;
Li, Wei
;
Guo, Li-Xia
  |  
收藏
  |  
浏览/下载:32/0
  |  
提交时间:2020/07/01
apatinib
drug-drug interaction
CYP3A4
CYP2C9
nifedipine
warfarin