机构

• 上海药物研究所 [5]
• 上海生物化学与细胞生... [3]
• 近代物理研究所 [3]
• 生物物理研究所 [1]
• 昆明植物研究所 [1]

采集方式

• OAI收割 [13]

内容类型

• 期刊论文 [13]

发表日期

• 2020 [1]
• 2014 [1]
• 2013 [2]
• 2011 [1]
• 2010 [1]
• 2009 [2]
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学科主题

• Biochemist... [1]
• Biochemist... [1]
• Biochemist... [1]
• Oncology [1]
• Pharmacolo... [1]
• Science & ... [1]
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筛选

浏览/检索结果: 共13条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择题名升序题名降序提交时间升序提交时间降序作者升序作者降序发表日期升序发表日期降序 BRD4 inhibitor nitroxoline enhances the sensitivity of multiple myeloma cells to bortezomib in vitro and in vivo by promoting mitochondrial pathway-mediated cell apoptosis 期刊论文  OAI收割 THERAPEUTIC ADVANCES IN HEMATOLOGY, 2020, 卷号: 11, 页码: 12 作者:  Li, Guang;  Zheng, Yan-Hua;  Xu, Li;  Feng, Juan;  Tang, Hai-Long   |  收藏  |  浏览/下载：18/0  |  提交时间：2020/12/24 apoptosis  BRD4 inhibitor  G1 phase cell cycle checkpoint  multiple myeloma   Identification of DW532 as a novel anti-tumor agent targeting both kinases and tubulin 期刊论文  OAI收割 ACTA PHARMACOLOGICA SINICA, 2014, 卷号: 35, 期号: 7, 页码: 916-928 作者:  Peng, Ting;  Wu, Jian-rui;  Tong, Lin-jiang;  Li, Meng-yuan;  Chen, Fang   |  收藏  |  浏览/下载：44/0  |  提交时间：2019/01/08 anti-cancer agent  hematoxylin  combretastatin  tyrosine kinase  EGFR  VEGFR  tubulin  cell cycle  spindle assembly checkpoint  anti-angiogenesis   Radiation-induced cellular senescence results from a slippage of long-term G(2) arrested cells into G(1) phase 期刊论文  OAI收割 CELL CYCLE, 2013, 卷号: 12, 页码: 1424-1432 作者:  Ye, Caiyong;  Wang, Jufang;  Zhang, Xurui;  Zhou, Guangming;  Wan, Jianghua   |  收藏  |  浏览/下载：29/0  |  提交时间：2018/07/05 Ionizing Radiation  g(2) Slippage  Senescence  Cell Cycle Checkpoint  Dna Damage Response  Mitotic Slippage   Apoptosis induction and G2/M arrest of 2-methyl-1,3,6-trihydroxy-9,10-anthraquinone from Rubia yunnanensis in human cervical cancer HeLa cells 期刊论文  OAI收割 PHARMAZIE, 2013, 卷号: 68, 期号: 4, 页码: 293-299 作者:  Zeng, Guang-Zhi 收藏  |  浏览/下载：40/0  |  提交时间：2015/05/14 2-Methyl-1,3,6-trihydroxy-9,10-anthraquinone (MTA)  one of the major components isolated from the traditional  Chinese medicine Rubia yunnanensis  exhibited inhibitory activity on the proliferation of several  human cancer cell lines. The results from an annexin V-FITC (fluoresein-5-isothiocyanate) apoptosis assay  and DNA content analysis showed that MTA exerted cytotoxicity via apoptosis induction and G2/M cell cycle  arrest in human cervical carcinoma HeLa cells. Further  MTA was found to induce apoptosis of HeLa cells  through the mitochondria-mediated pathway. It caused the translocation of Bax to the mitochondria and  release of cytochrome c into the cytosol  which caused the cleavage of caspase and poly(ADP-ribose)  polymerase and finally triggered the apoptosis. Furthermore  the p53/p21/Cdc2-cyclin B1 signaling was  found related to the G2/M arrest caused by MTA. The over-expression of p21 and down-expression of  cyclin B1 caused by MTA inactivated the Cdc2-cyclin B1 complex of G2/M checkpoint and finally caused  the G2/M arrest in HeLa cells. This study demonstrated that MTA is a potential anti-cancer component of  R. yunnanensis  a folk anti-cancer herb used in Yunnan  China.   Mechanisms of increased risk of tumorigenesis in Atm and Brca1 double heterozygosity 期刊论文  OAI收割 RADIATION ONCOLOGY, 2011, 卷号: 6, 期号: 1, 页码: 8 作者:  Wang, Jufang;  Su, Fengtao;  Smilenov, Lubomir B.;  Zhou, Libin;  Hu, Wentao   |  收藏  |  浏览/下载：54/0  |  提交时间：2018/05/31 heterozygosity  haploinsufficiency  tumorigenesis  DNA damage  cell cycle checkpoint  genomic instability   Potential role of DNA-dependent protein kinase in cellular resistance to ionizing radiation 期刊论文  OAI收割 NUCLEAR SCIENCE AND TECHNIQUES, 2009, 卷号: 20, 期号: 2, 页码: 87-92 作者:  Li Ning;  Zhang Hong;  Wang Yanling;  Wang Xiaohu;  Hao Jifang   |  收藏  |  浏览/下载：23/0  |  提交时间：2010/10/29 DNA-dependent protein kinase (DNA-PK)  Cell cycle checkpoint  Apoptosis  Radiosensitivity   Chk1 prevents abnormal mitosis of S-phase HeLa cells containing DNA damage 期刊论文  OAI收割 CHINESE SCIENCE BULLETIN, 2009, 卷号: 54, 期号: 22, 页码: 4205-4213 作者:  Li, XF;  Ward, T;  Yao, XB;  Wu, JR 收藏  |  浏览/下载：27/0  |  提交时间：2015/07/22 cell cycle  DNA damage checkpoint  DNA replication checkpoint  Chk1  methyl methanesulfnate   Effects of Argonaute Subfamily Proteins on Cell Cycle of Human Cancer Cells 期刊论文  OAI收割 PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS, 2008, 卷号: 35, 期号: 12, 页码: 1394-1402 Jiang Lin; Pan ShuJuan; Ge YuZhi; Yin James Q(Yin QinWei) 收藏  |  浏览/下载：16/0  |  提交时间：2013/12/25 RNAi  Argonaute  qRT-PCR  cell cycle  G0/G1 checkpoint   P53 protein activates the transcription of human proliferating cell nuclear antigen in response to 4-nitroquinoline N-oxide treatment 期刊论文  OAI收割 INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2005, 卷号: 37, 期号: 2, 页码: 416-426 作者:  Li, YY;  Wang, L;  Li, SH;  Guo, TQ;  Guo, XY 收藏  |  浏览/下载：25/0  |  提交时间：2015/07/22 4-nitroquinoline N-oxide  proliferating cell nuclear antigen  p53  DNA damage  cell cycle checkpoint