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浏览/检索结果: 共12条，第1-10条 帮助

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A novel cell cycle blocker extracted from Stellera chamaejasme L. inhibits the proliferation of hepatocarcinoma cells 期刊论文  OAI收割
ONCOLOGY REPORTS, 2016, 卷号: 35, 期号: 6, 页码: 3480-3488
作者:  Kan, Xiao-Xi;  Li, Qi;  Chen, Xi;  Wang, Ya-Jie;  Li, Yu-Jie
  |  收藏  |  浏览/下载：23/0  |  提交时间：2019/06/20
Apoptosis induction and G2/M arrest of 2-methyl-1,3,6-trihydroxy-9,10-anthraquinone from Rubia yunnanensis in human cervical cancer HeLa cells 期刊论文  OAI收割
PHARMAZIE, 2013, 卷号: 68, 期号: 4, 页码: 293-299
作者:  Zeng, Guang-Zhi;  Fan, Jun-Ting;  Xu, Jun-Ju;  Li, Yan;  Tan, Ning-Hua
收藏  |  浏览/下载：42/0  |  提交时间：2015/05/14
2-Methyl-1,3,6-trihydroxy-9,10-anthraquinone (MTA)  one of the major components isolated from the traditional  Chinese medicine Rubia yunnanensis  exhibited inhibitory activity on the proliferation of several  human cancer cell lines. The results from an annexin V-FITC (fluoresein-5-isothiocyanate) apoptosis assay  and DNA content analysis showed that MTA exerted cytotoxicity via apoptosis induction and G2/M cell cycle  arrest in human cervical carcinoma HeLa cells. Further  MTA was found to induce apoptosis of HeLa cells  through the mitochondria-mediated pathway. It caused the translocation of Bax to the mitochondria and  release of cytochrome c into the cytosol  which caused the cleavage of caspase and poly(ADP-ribose)  polymerase and finally triggered the apoptosis. Furthermore  the p53/p21/Cdc2-cyclin B1 signaling was  found related to the G2/M arrest caused by MTA. The over-expression of p21 and down-expression of  cyclin B1 caused by MTA inactivated the Cdc2-cyclin B1 complex of G2/M checkpoint and finally caused  the G2/M arrest in HeLa cells. This study demonstrated that MTA is a potential anti-cancer component of  R. yunnanensis  a folk anti-cancer herb used in Yunnan  China.  
Curcumin Induces Cell Death and Restores Tamoxifen Sensitivity in the Antiestrogen-Resistant Breast Cancer Cell Lines MCF-7/LCC2 and MCF-7/LCC9 期刊论文  OAI收割
MOLECULES, 2013, 卷号: 18, 期号: 1, 页码: 701-720
作者:  Jiang, Min;  Huang, Ou;  Zhang, Xi;  Xie, Zuoquan;  Shen, Aijun
  |  收藏  |  浏览/下载：28/0  |  提交时间：2019/01/08
长牡蛎（Crassostrea gigas）细胞周期调控关键基因cdk1和cyclinB3基因的克隆及其在性腺发育中作用的初步研究 学位论文  OAI收割
硕士: 中国科学院研究生院, 2011
王桐
收藏  |  浏览/下载：45/0  |  提交时间：2014/08/08
长牡蛎（Crassostrea gigas）cdk1 和cyclin B3 基因的克隆及其在性腺发育中作用的初步研究 学位论文  OAI收割
硕士, 北京: 中国科学院研究生院, 2011
王桐
收藏  |  浏览/下载：65/0  |  提交时间：2012/06/25
Cell cycle suspension A novel process lurking in G(2) arrest 期刊论文  OAI收割
CELL CYCLE, 2011, 卷号: 10, 页码: 1468-1476
作者:  Furusawa, Yoshiya;  Zhou, Guangming;  He, Jinpeng;  Li, Junhong;  Ye, Caiyong
  |  收藏  |  浏览/下载：29/0  |  提交时间：2018/05/31
B5, a novel pyrrole-substituted indolinone, exerts potent antitumor efficacy through G2/M cell cycle arrest 期刊论文  OAI收割
INVESTIGATIONAL NEW DRUGS, 2010, 卷号: 28, 期号: 1, 页码: 26-34
作者:  Xiong, Xishan;  Zhang, Yingwei;  Gao, Xiang;  Dong, Zheyi;  Li, Lin
  |  收藏  |  浏览/下载：26/0  |  提交时间：2019/01/08
Discovery and characterization of a novel inhibitor of CDC25B, LGH00045 期刊论文  OAI收割
ACTA PHARMACOLOGICA SINICA, 2008, 卷号: 29, 期号: 10, 页码: 1268-1274
作者:  Feng, Xu;  Wang, Li-na;  Zhou, Yue-yang;  Yu, Hai-ping;  Shen, Qiang
  |  收藏  |  浏览/下载：24/0  |  提交时间：2019/01/08
discoveryandcharacterizationofanovelinhibitorofcdc25blgh00045 期刊论文  OAI收割
actapharmacologicasinica, 2008, 卷号: 29, 期号: 10, 页码: 1268
作者:  Xu FENG;  Lina WANG;  Yueyang ZHOU;  Haiping YU;  Qiang SHEN
  |  收藏  |  浏览/下载：37/0  |  提交时间：2020/07/01
Effect of allitridi on inducing mitotic arrest in human gastric cell line SGC-7901 and its possible mechanism 期刊论文  OAI收割
CHINESE JOURNAL OF CANCER RESEARCH, 2008, 卷号: 20, 期号: 2, 页码: 126-132
作者:  Chen Tiejun;  Ha Minwen;  Gong Yuehua;  Xu Qian;  Yuan Yuan
  |  收藏  |  浏览/下载：18/0  |  提交时间：2021/02/02