中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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Pharmacokinetics, mass balance, and metabolism of [
14
C]FCN-437c, a selective and potent CDK4/6 inhibitor in humans
期刊论文
OAI收割
CANCER CHEMOTHERAPY AND PHARMACOLOGY, 2025, 卷号: 95, 期号: 1, 页码: 12
作者:
Gao, Lei
;
Ma, Sheng
;
Yan, Shu
;
Zhang, Hua
;
Tian, Ling
  |  
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2025/07/25
FCN-437c
CDK4/6 inhibitor
Mass balance
Radiopharmacokinetics
Drug metabolism
Smart drug delivery platforms reprogramming cancer immune cycle to mitigate immune resistance of pancreatic tumors
期刊论文
OAI收割
ADVANCED DRUG DELIVERY REVIEWS, 2025, 卷号: 224, 页码: 27
作者:
Zhang, Ping
;
Pan, Jiaxing
;
Lin, Shutong
;
Peng, Bo
;
An, Caiyan
  |  
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2025/08/20
Pancreatic cancer
Cancer immune cycle
Immune resistance
Drug delivery systems
Stimuli-responsive
Guiding precision medicine strategy for intravenous ginsenosides via pharmacokinetic-informed bioinformatic approaches: a study on XueShuanTong
期刊论文
OAI收割
PHYTOMEDICINE, 2025, 卷号: 143, 页码: 18
作者:
Jia, Wei-Wei
;
Tian, Nan-Nan
;
Song, Zi-Jing
;
Lan, Xiao-Fang
;
Yang, Xi-He
  |  
收藏
  |  
浏览/下载:1/0
  |  
提交时间:2025/08/20
Precision medicine
Physiologically based pharmacokinetic model
Ginsenoside
Albumin-facilitated dissociation
Drug interaction
Drug transporter
Hepatic impairment
Sorafenib resistance and therapeutic strategies in hepatocellular carcinoma
期刊论文
OAI收割
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER, 2025, 卷号: 1880, 期号: 3, 页码: 17
作者:
Zhang, Weijing
;
Hong, Xuechuan
;
Xiao, Yuling
;
Wang, Hongbo
;
Zeng, Xiaodong
  |  
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2025/06/23
Hepatocellular carcinoma
Sorafenib
Drug resistance
Therapeutic strategy
Advancing active compound discovery for novel drug targets: insights from AI-driven approaches
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2025, 页码: 12
作者:
Wang, Xing-you
;
Chen, Yang
;
Li, Yu-fan
;
Wei, Chao-yang
;
Liu, Meng-ya
  |  
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2025/08/20
AI-driven drug discovery
novel drug targets
molecular design
ligand exploration
phenotypic drug discovery
undruggable targets
Risk assessment of CYP3A induction by ginsenoside's metabolites from oral Panax notoginseng (sanqi) extract
期刊论文
OAI收割
JOURNAL OF ETHNOPHARMACOLOGY, 2025, 卷号: 349, 页码: 11
作者:
Deng, Yang
;
Du, Jing
;
He, Xin
;
Dong, Yan-Xi
;
Wang, Xiao-Lei
  |  
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2025/08/20
Panax notoginseng
Ginsenoside
Intestinal microbiota
CYP3A induction
Drug interaction
Contrastive learning-based drug screening model for GluN1/GluN3A inhibitors
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2025, 页码: 13
作者:
Li, Kun
;
Zeng, Yue
;
Xiong, Yi-da
;
Wu, Hao-chen
;
Fang, Sui
  |  
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2025/08/20
drug-target affinity prediction
virtual screening
contrastive learning
graph neural network
N
-methyl-
D
-aspartate (NMDA) receptors
GluN3A subunit.
Molecular basis for ligand recognition and receptor activation of the prostaglandin D2 receptor DP1
期刊论文
OAI收割
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2025, 卷号: 122, 期号: 22, 页码: 11
作者:
Xu, Jiuyin
;
Wu, Yanli
;
Xu, Youwei
;
Li, Yang
;
He, Xinheng
  |  
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2025/08/20
prostaglandin D2 receptor 1
receptor activation
drug design
Design, synthesis, and activity evaluation of indole derivatives as potential stabilizers for p53 Y220C
期刊论文
OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2025, 卷号: 121, 页码: 9
作者:
Li, Linquan
;
Gu, Xi
;
Meng, Jingyi
;
Wen, Yiming
;
Yi, Jing
  |  
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2025/05/27
p53 Y220C
Synthesis
Structural modification
Drug design
Nanobody-based drug delivery systems for cancer therapy
期刊论文
OAI收割
JOURNAL OF CONTROLLED RELEASE, 2025, 卷号: 381, 页码: 29
作者:
Liu, Lin
;
Tu, Bin
;
Sun, Yao
;
Liao, Lingling
;
Lu, Xiaoling
  |  
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2025/04/24
Nanobody
VHH
Cancer therapy
Targeted drug delivery systems
Nanobody modification